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New application of N-acetylcysteine medicine

A technology of acetylcysteine ​​and drugs, applied in drug combinations, medical preparations containing active ingredients, pharmaceutical formulas, etc., can solve problems such as bone marrow cells and egg cell chromosomal abnormalities, genotoxicity, and no specific antidote

Inactive Publication Date: 2013-09-25
ZHENGZHOU TOBACCO RES INST OF CNTC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Jha et al. [15] Crotonaldehyde was found to be genotoxic in vivo, causing chromosomal abnormalities in bone marrow cells and oocytes of Swiss albino mice, and elevated dominant lethal mutations
(4) May be carcinogenic
[0009] The routes through which crotonaldehyde enters the body mainly include the skin, respiratory tract, eyes, digestive tract, nasal cavity, etc. Currently, there is no specific antidote for crotonaldehyde poisoning

Method used

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  • New application of N-acetylcysteine medicine
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  • New application of N-acetylcysteine medicine

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0058] Embodiment 1, the pharmacodynamics test of N-acetylcysteine ​​as the antidote of crotonaldehyde poisoning

[0059] 1 Experimental method

[0060] 1.1 Cell culture

[0061] NR8383 cells, from the American ATCC cell bank, Number: CRL-2192TM. NR8383 (normal rat, August 3, 1983) was derived from normal rat alveolar macrophages during lung lavage. NR8383 cells are similar in function to primary rat alveolar macrophages and human alveolar macrophages, providing a uniform source of highly responsive alveolar macrophages, which can be used to study the activity of alveolar macrophages in vitro.

[0062] NR8383 cell culture growth environment: F12K medium supplemented with 2mM L-glutamine, 1.5g / L sodium bicarbonate, 100U / ml penicillin, 100μg / ml streptomycin and 15% fetal bovine serum. This recipe is suitable for filling the gas phase with 5% carbon dioxide at 37°C. Passage every 2-3 days.

[0063] Some of the cells grew in suspension and some grew on the wall. When passa...

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Abstract

The invention discloses a new application of a N-acetylcysteine medicine. The new application of the N-acetylcysteine medicine is an application in preparing a medicine for preventing and / or treating crotonaldehyde positioning. Shown by pharmacodynamic experiments, the N-acetylcysteine has the advantages that the generation of oxidative stress of cells and tissues due to crotonaldehyde can be reduced or antagonized, the damage effect such as cell apoptosis caused by the crotonaldehyde is restrained by the antioxidation effect, and the medical curative effect is obvious.

Description

technical field [0001] The invention relates to a new medicine application of N-acetylcysteine. Background technique [0002] N-acetylcysteine, hereinafter referred to as NAC, has the following structural formula: [0003] [0004] NAC is suitable for dyspnea caused by a large amount of sticky sputum, such as difficulty in expectoration after surgery, acute and chronic bronchitis, bronchiectasis, tuberculosis, pneumonia, emphysema, etc. Trachea etc. NAC can still be used for the detoxification of acetaminophen poisoning, and there is no report on the use of N-acetylcysteine ​​​​for the treatment of crotonaldehyde poisoning. [0005] Crotonaldehyde (Crotonaldehyde) is a highly volatile electrophilic organic compound, which has attracted much attention due to its wide range of sources, diverse toxic effects, and low hazard threshold. [1] . [0006] Crotonaldehyde pollution involves all aspects of people's lives: (1) Crotonaldehyde is contained in food: the content of cr...

Claims

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Application Information

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IPC IPC(8): A61K31/198A61P39/02
Inventor 谢剑平杨必成朱茂祥杨陟华潘秀颉
Owner ZHENGZHOU TOBACCO RES INST OF CNTC
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