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Method of enriching arecoline by using H103 type macroporous adsorption resin

A technology of H103, pore adsorption, applied in directions such as organic chemistry, can solve the problem of no separation and purification method of arecoline, and achieve the effects of simple and easy operation, convenient recovery and reduced use cost.

Inactive Publication Date: 2013-10-09
INST OF AGRO FOOD SCI & TECH CHINESE ACADEMY OF AGRI SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

In recent years, macroporous adsorption resin technology has been widely used in the separation and refinement of alkaloids, such as Aconitum alkaloids, berberine in Coptis chinensis, Sophora alopecuroides, ephedrine, and apokaloids in lotus leaves. Kinds of macroporous adsorption resins have no method for the separation and purification of arecoline

Method used

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  • Method of enriching arecoline by using H103 type macroporous adsorption resin

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] Dry the betel nut and crush it into dry betel nut powder, weigh 1 kg and add 4 kg of distilled water to soak for 1 hour, then ultrasonically extract for 15 minutes, filter to obtain 4 kg of the extract, adjust the pH of the extract to 6.2 with 0.1 mol / mL hydrochloric acid solution, and set aside. Weigh 0.6 kg (wet weight) of the H103 type macroporous resin and put it into an adsorption column for subsequent use. The flow rate of the above sample is 1BV / h, and the obtained extract is added to the H103 type macroporous resin column for dynamic adsorption of arecoline. All the extracts flowed through the H103 macroporous resin adsorption column, washed with 4L of deionized water, and then 4L of 50% ethanol was used to elute arecoline at a desorption flow rate of 1BV / h, and the eluate was collected.

Embodiment 2

[0030] Dry the betel nut and crush it into dry betel nut powder, weigh 1 kg and add 4 kg of distilled water to soak for 1 hour, then ultrasonically extract for 22 minutes, filter to obtain 4 kg of the extract, adjust the pH of the extract to 6.2 with 0.1 mol / mL hydrochloric acid solution, and set aside. Take by weighing H103 type macroporous resin 0.7kg (wet weight) and put it into the adsorption column for subsequent use, the sample flow rate is 2BV / h and the extract obtained in Example 1 is added to the H103 type macroporous adsorption resin column to carry out the dynamic adsorption of arecoline . After all the extracts flowed through the H103 macroporous resin adsorption column, they were washed with 6L of deionized water, and then 8L of 60% ethanol was used to elute arecoline at a desorption flow rate of 2BV / h, and the eluate was collected.

Embodiment 3

[0032] Dry the betel nut and crush it into dry betel nut powder, weigh 1 kg and add 4 kg of distilled water to soak for 1 hour, then ultrasonically extract for 30 minutes, filter to obtain 4 kg of the extract, adjust the pH of the extract to 6.2 with 0.1 mol / mL hydrochloric acid solution, and set aside. Take by weighing H103 type macroporous resin 0.8kg (wet weight) and put it into the adsorption column for subsequent use, and the sample flow rate is 3BV / h and the extract obtained in Example 1 is added to the H103 type macroporous resin column to carry out the dynamic adsorption of arecoline . All the extracts flowed through the H103 macroporous resin adsorption column, washed with 8L of deionized water, and then eluted arecoline with 12L of 70% ethanol. The desorption flow rate was 3BV / h, and the eluate was collected.

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Abstract

The invention discloses a method for enriching arecoline by using H103 type macroporous adsorption resin. The method comprises the following steps: step one, drying and crushing areca-nut into areca-nut dry powder, soaking in distilled water, and ultrasonically extracting to obtain extracting solution; step two, adding the extracting solution in H103 type macroporous adsorption resin column dynamically adsorb the arecoline; step three, after dynamically adsorbing the arecoline, adding deionized water in H103 type macroporous adsorption resin column, washing, adding ethanol in the H103 type macroporous adsorption resin column to elute the adsorbed arecoline, collecting the eluting solution; step four, reducing pressing and concentrating the eluting solution by using rotary evaporator to obtain the arecoline. The method disclosed by the invention has the beneficial effect that the arecoline is extracted by using environment-friendly water extraction; the eluting solution is ethanol which is convenient to recycle, and the finally obtained arecoline is high in refining degree. The method is easy to operate and can be applied to large-scale production.

Description

technical field [0001] The invention relates to the technical field of natural product separation, in particular to a method for enriching arecoline by using H103 macroporous adsorption resin. Background technique [0002] Macroporous adsorption resin, also known as fully porous resin and polymer adsorbent, is a kind of high molecular polymer characterized by adsorption and has the function of concentrating and separating organic matter. Macroporous resin is prepared by polymerizing monomers and additives such as crosslinking agent, porogen, and dispersant through polymerization. After the polymer is formed, the porogen is removed, leaving holes of various sizes and shapes interpenetrating in the resin. Therefore, the macroporous resin has a high internal porosity in a dry state, and the pore diameter is relatively large, between 100-1000nm, so it is called a macroporous adsorption resin. [0003] Areca catechu L. is a plant of the genus Areca of the palm family (Palmae), ...

Claims

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Application Information

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IPC IPC(8): C07D211/78
Inventor 张春江吕飞杰
Owner INST OF AGRO FOOD SCI & TECH CHINESE ACADEMY OF AGRI SCI
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