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Method for preparing stabilized ordered-molecule microcapsules from unsaturated fatty acid

A technology of unsaturated fatty acids and microcapsules, which is applied in the field of green biomass processing and utilization, can solve the problems of complicated operation procedures, uncontrolled release, and low encapsulation efficiency, and achieve the effect of simple and economical operation process

Inactive Publication Date: 2013-11-13
JIANGNAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

It can be seen that the current preparation of unsaturated fatty acids is usually disordered microcapsules, and in the preparation process, a variety of capsule materials are used, which has the disadvantages of complex operation procedures, low encapsulation efficiency, and no controlled release.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] The pH of the conjugated linoleic acid aqueous solution is adjusted to 8.6, and the mass concentration is 0.08%, so that the conjugated linoleic acid in the solution can be assembled in an orderly manner. The results of cryo-transmission electron microscopy showed that the ordered molecular assembly of conjugated linoleic acid resulted in a single-walled vesicle-like structure with a particle size range of 20-50 nm; the results of dynamic laser light scattering also showed that the vesicles of conjugated linoleic acid The particle size range of the ordered molecular assembly is 20-50nm. The pH value of the vesicular molecular ordered assembly was readjusted at intervals of 1 between 1 and 14. The system gradually became turbid below pH 8 until the oil-water phase, indicating that the vesicular molecular ordered assembly disintegrated below pH 8. The vesicle-like molecularly ordered assembly can already be used as molecularly ordered microcapsules for embedding and susta...

Embodiment 2

[0023] In order to obtain stabilized vesicular molecularly ordered microcapsules, the vesicular molecularly ordered assembly solution of conjugated linoleic acid obtained in Example 1 was passed through N 2 After 30 minutes, add water-soluble free radical initiator ammonium persulfate accounting for 23% of the mass of conjugated linoleic acid, trigger thermal polymerization of conjugated linoleic acid molecules in vesicles at 80°C for 10 hours, and then dialyze to remove the initiator . The results of transmission electron microscopy showed that the structure after cross-linking in the vesicles still maintained the molecularly ordered microcapsule structure and particle size before cross-linking; the results of dynamic laser light scattering supported the vesicles of the conjugated linoleic acid after self-crosslinking The particle size range of the molecularly ordered microcapsules is still 20-50 nm, which is consistent with the shape and size of the vesicle-like molecularly...

Embodiment 3

[0025] Adjust the pH of the conjugated linoleic acid aqueous solution to 8.8 and the mass concentration to 20%, and control the molecular orderly assembly of the conjugated linoleic acid in the solution. The results of cryo-transmission electron microscopy showed that the molecularly ordered assembly of conjugated linoleic acid had a rod-like micelle structure; the results of dynamic laser light scattering showed that the prepared molecularly ordered assembly of conjugated linoleic acid The particle size range is 100-200nm.

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Abstract

The invention relates to a method for preparing stabilized ordered-molecule microcapsules from unsaturated fatty acid. The method comprises the steps of firstly controlling unsaturated fatty acid molecules to be subjected to ordered molecule assembly through adjusting a concentration or pH value of an unsaturated fatty acid solution so as to obtain an ordered micelle or vesicle shaped molecule assembly solution of unsaturated fatty acid, then introducing N2 for treatment for 30 minutes, adding a free radical initiator for initiation, carrying out thermal polymerization or radiation polymerization, and initiating unsaturated fatty acid in the ordered molecule assembly solution to be subjected to micelle or vesicle internal polymerization or self-crosslinking reaction, thereby preparing the stabilized ordered-molecule microcapsules of unsaturated fatty acid. According to the method, the ordered molecule assembly activity and polymerizable activity of unsaturated fatty acid are utilized, the stabilized microcapsules can be prepared without other chemical adjuvants, and the operation process is simple and economical; and the stabilized ordered-molecule microcapsules are prepared.

Description

【Technical field】 [0001] The invention relates to the field of green processing and utilization of biomass, in particular to a method for preparing stabilized molecularly ordered microcapsules from unsaturated fatty acids. 【Background technique】 [0002] At present, the commonly used embedding slow-release carriers in pharmaceuticals, food and cosmetics are mainly traditional microcapsules and molecularly ordered micro / ultramicrocapsules, in which molecularly ordered micro / ultramicrocapsules are obtained by means of orderly assembly of wall material molecules, or further The stabilized molecular ordered assembly obtained by cross-linking the above molecular ordered assembly includes structures such as liposomes, vesicles, nanotonol, and macromolecule micelles or microspheres. However, the large particle size of traditional microcapsules limits certain application fields, and the disordered structure leads to poor controlled release; liposomes are the earliest molecularly ord...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K47/12A61K9/50A61K8/11A61K8/36A23L1/29A23L33/00
Inventor 方云樊晔夏咏梅
Owner JIANGNAN UNIV
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