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Natural medicine extract as well as preparation method and application thereof

A technology of natural medicines and extracts, used in drug combinations, pharmaceutical formulations, antitumor drugs, etc.

Inactive Publication Date: 2013-11-20
石强
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

In recent years, with the advent and popularization of chemotherapy drugs such as 5-fluorouracil, taxanes, hydroxycamptothecin, irinotecan, Xeloda, etc., the incidence of chemotherapy-related diarrhea has increased year by year. Treatment can easily lead to dehydration, malnutrition, serum electrolyte disorder, acid-base balance disorder, etc., which not only bring great disadvantages to the recovery of the body, but also bring certain difficulties to periodic chemotherapy. Effective treatment has become an important part of the overall treatment of cancer patients
[0003]Chemotherapy-associated diarrhea, in terms of its clinical manifestations, belongs to the category of "diarrhea" in traditional Chinese medicine. The research on diarrhea in traditional Chinese medicine is remarkable, but at present There is no Chinese patent medicine that can relieve diarrhea and increase efficacy against cancer chemotherapy

Method used

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  • Natural medicine extract as well as preparation method and application thereof

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Embodiment approach

[0031] The first step: preparation of various extracts

[0032] (1) Preparation of the concentrated extract of Schisandra radish decocted in water

[0033] According to the compatibility ratio of 1-4:1, take schisandra and radish, soak in distilled water, heat and decoct, filter, add distilled water to the dregs, soak, decoct, and filter in the same way, mix the two filtrates, heat and concentrate, and ultrafilter Membrane filtration, drying under reduced pressure, that is.

[0034] (2) Preparation of Schisandra polysaccharide

[0035] Take the dried fruit of Schisandra chinensis, crush and sieve, degrease with absolute ethanol Soxhlet reflux, dry, add water to extract at 90°C, filter, concentrate the extract under reduced pressure, analyze with 95% ethanol, collect the precipitate by centrifugation, and wash the precipitate with acetone and ether respectively Wash with absolute ethanol, and freeze-dry to obtain Schisandra polysaccharide.

[0036] (3) Preparation of radishi...

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Abstract

The invention relates to natural medicine extract as well as a preparation method and an application thereof. The natural medicine extract is composed of a water decocted concentration extract of schisandra chinensis and semen raphani, schisandra chinensis polysaccharide and sulforaphane at a ratio of (4-6):(5-9):(3-5), and the natural medicine extract composition has an unexceptionable curative effect on diarrhea related to cancer chemotherapy and meanwhile has a synergistic effect on cancer chemotherapy.

Description

technical field [0001] The present invention relates to a natural medicine extract, more specifically to a natural medicine extract composed of Schisandra radish extract, Schisandra polysaccharide and radish, a preparation method of the natural medicine extract and the natural medicine extract. Use of the medicinal extract in the preparation of a medicine for reducing cancer chemotherapy-related diarrhea and synergizing cancer treatment. Background technique [0002] Malignant tumor is one of the main diseases that endanger human survival and health at present. Its treatment methods include surgery, chemotherapy, radiotherapy, and traditional Chinese medicine treatment, and the effect of chemotherapy on tumors is particularly prominent. Chemotherapy drugs used alone or in combination can cause toxic and side effects such as diarrhea in patients. Diarrhea after tumor chemotherapy is also called chemotherapy-associated diarrhea. In recent years, with the advent and populari...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/57A61K36/79A61P35/00A61P1/12A61K31/715A61K31/26
Inventor 石强
Owner 石强