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Preparation method of polyurethane bandage with functions of promoting blood circulation and removing blood stasis and bandage prepared by method

A technology for promoting blood circulation and removing blood stasis and polyurethane, which is applied in the field of medical and sanitary products, can solve the problems of non-functional polyurethane bandage products, and achieve the effects of promoting early recovery, good plasticity and improving microcirculation.

Active Publication Date: 2013-11-27
ZHENDE MEDICAL CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In the patents, only the production method of polyurethane bandages is proposed, and the polyurethane bandage products are not functional, and can only play a simple external fixation role.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] ① Preparation of polyurethane prepolymer

[0031] Add 100 parts of 4,4'-diphenylmethane diisocyanate, 0.5 parts of benzoyl chloride stabilizer and 2.5 parts of silicone defoamer After stirring at 45°C for 30 minutes, slowly add 20 parts of polypropylene glycol with a molecular weight of 800-1100, continue heating and stirring for 60 minutes, then add 35 parts of polypropylene glycol with a molecular weight of 1800-2200 dropwise, and add the catalyst dimethylethanolamine after 2 hours of reaction 3 parts, 5 parts of lubricant silicone oil, continue heating and stirring for 15 minutes.

[0032] ②Preparation of chitosan microspheres with drugs for promoting blood circulation and removing blood stasis

[0033] Dissolve 50 parts of chitosan in 5% acetic acid solution with a mass fraction of 5%, stir until completely dissolved, centrifuge and coagulate to obtain the chitosan solution; after standing for 36 hours, filter under reduced pressure, wash with absolute ethanol unti...

Embodiment 2

[0038] ① Preparation of polyurethane prepolymer

[0039] In a four-port reactor with a stirrer and a thermometer that feeds high-purity nitrogen, add 100 parts of 2,4'-diphenylmethane diisocyanate, 1.8 parts of benzoyl chloride and 3.2 parts of silicone defoamer. After stirring at 30°C for 30 minutes, slowly add 18 parts of polytetrahydrofuran diol with a molecular weight of 800-1100, continue heating and stirring for 100 minutes, then add 40 parts of polypropylene glycol with a molecular weight of 1800-2200 dropwise, and add catalyst triethylene glycol after 2.5 hours of reaction. 1-8 parts of diamine, 3-10 parts of silicone oil lubricant, continue heating and stirring for 50 minutes.

[0040] ②Preparation of chitosan microspheres with drugs for promoting blood circulation and removing blood stasis

[0041]Dissolve 50 parts of chitosan in 13% acetic acid solution with a mass fraction of 13%, stir until completely dissolved, and centrifuge to coagulate the chitosan solution; ...

Embodiment 3

[0045] ① Preparation of polyurethane prepolymer

[0046] In a four-port reactor with a stirrer and a thermometer that is fed with high-purity nitrogen, add 100 parts of 4,4'-diphenylmethane diisocyanate, 4.2 parts of propionyl chloride and 3.5 parts of silicone defoamer. After stirring at ℃ for 30 minutes, slowly add 30 parts of polyether triol with a molecular weight of 300-600, continue heating and stirring for 70 minutes, then add 10 parts of polytetrahydrofuran diol with a molecular weight of 1800-2200 dropwise, react for 1.5 hours, and then add an organotin catalyst Such as 3 parts of dibutyltin dilaurate, 5 parts of silicone oil lubricant, continue to heat and stir for 45 minutes.

[0047] ②Preparation of chitosan microspheres with drugs for promoting blood circulation and removing blood stasis

[0048] Dissolve 50 parts of chitosan in 15% acetic acid solution, stir until completely dissolved, obtain chitosan solution, and centrifuge to coagulate. After standing still ...

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Abstract

The invention discloses a preparation method of a polyurethane bandage with the functions of promoting blood circulation and removing blood stasis and the bandage prepared by the method. The preparation method comprises the following steps of preparing a polyurethane prepolymer and chitosan microspheres with the functions of promoting blood circulation and removing blood stasis, then adjusting the temperature of the polyurethane prepolymer to 55 DEG C, coating the polyurethane prepolymer on base cloth by adopting a double-roller coating method under a nitrogen protection environment in which the moisture content of air is lower than 10%, feeding and rolling the base cloth coated with the polyurethane prepolymer, uniformly spraying the chitosan microspheres with the functions of promoting blood circulation and removing blood stasis, finally rolling, shearing and packaging by using an aluminum plastic compound bag. The preparation method is simple in technology and low in cost. The bandage prepared by the method can be used for accelerating the blood circulation of an affected region and has the functions of promoting blood circulation and removing blood stasis.

Description

technical field [0001] The invention relates to the technical field of medical and sanitary products, in particular to a method for preparing a water chain-extended medical polyurethane bandage with the function of promoting blood circulation and removing blood stasis, and the bandage prepared by the method. Background technique [0002] In the early 1980s, Bayer first proposed coating polyurethane prepolymers on mesh fabrics to make bandages, which was a major development in the field of orthopedic treatment. The method of using this bandage is to contact the bandage with water at room temperature first, and then wrap it around the affected part of the patient. The polyurethane prepolymer coated on the base cloth will react with water and gradually harden from the initially soft plastic bandage. Finally, a rigid material is formed to fix the patient's affected part. At this time, the bandage has a high strength and its shape cannot be changed. Because the bandage has the a...

Claims

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Application Information

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IPC IPC(8): A61L15/28A61L15/26A61L15/44A61L15/42
Inventor 王栋陆莹沈博强胡修元张新强
Owner ZHENDE MEDICAL CO LTD
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