New artemisinin extraction process

Abstract

The invention relates to a simple process for extracting artemisinin from artemisa apiacea. The process comprises: placing dried artemisa apiacea leaf in a 3-mouthed bottle as a raw material, adding a solvent / water mixing system, soaking for 1-2 h, carrying out ultrasonic assisted extraction for 2-4 h, and repeating the extraction two times, wherein the third extraction solution is mechanically applied, the mixed extraction solution is used for the next separation and purification processes, and high-performance liquid chromatography detection results show that an extraction recovery rate is more than 98%. The method has characteristics of simple process and simple operation.

Description

technical field [0001] The invention relates to a new extraction process of natural antimalarial medicine raw material artemisinin. Background technique [0002] Artemisinin is a new type of sesquiterpene compound with a peroxy ring and a lactone ring. This special peroxy structure makes artemisinin have a wide range of biological activities, and early discovery of anti-malarial activity, anti-parasitic Insect activity, antibacterial, antipyretic and other activities, recently American scientists found that it has good anticancer activity, especially for breast cancer and ovarian cancer. Artemisinin was first extracted and isolated by the research group of Professor Tu Youyou of the Chinese Academy of Military Medical Sciences, and was used in anti-malarial research. It was successfully developed in the 1980s and became a new drug with independent intellectual property rights in my country. Artemisinin and a series of more active artemisinin derivatives developed later, art...