Preparation method of surface enhanced Raman scattering substrate based on spirogram ordered porous membrane

A surface-enhanced Raman and porous membrane technology, applied in the field of material chemistry, can solve the problems of high cost and poor enhancement effect, and achieve the effect of low cost, obvious Raman enhancement effect and good application prospect.

Inactive Publication Date: 2013-11-27
ZHEJIANG UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

There is a literature report on a method for preparing a needle-shaped silver array SERS substrate based on the breath diagram method, which significantly enhances the Raman scattering signal of rhodamine 6G, but requires gas sputtering deposition equipment, and the cost is still high (see Chem. . Commun. 2010, 46, 2298-2300)
It is also reported in the literature that polymer / gold nanoparticle composite breath pattern ordered porous film can also be used as a SERS substrate. The preparation method is relatively simple, but the enhancement effect is not good (see Langmuir 2013, 29, 4235-4241)
It can be seen that there is no preparation process for SERS substrates with excellent Raman signal enhancement effects that do not require the use of large-scale equipment and are based on a simple and efficient breath map method.

Method used

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  • Preparation method of surface enhanced Raman scattering substrate based on spirogram ordered porous membrane

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Embodiment 1

[0020] Styrene / dimethylaminoethyl methacrylate block copolymer (PS- b -PDMAEMA) was dissolved in carbon disulfide to prepare 2 mg / mL PS- b -PDMAEMA solution, PS- b -The molar percentage of styrene units in PDMAEMA is 90%, and 50 μL of PS- b -PDMAEMA solution is evenly spread on the polyester film, quickly placed in an environment with a relative humidity of 80%, and taken out after the solvent is volatilized, and an ordered porous membrane with a breath pattern is obtained, and the pore size is 2.0 μm; the preparation of polymethacrylic acid The ethanol solution of dimethylaminoethyl ester (PDMAEMA) has a concentration of 30 mg / mL, the number average molecular weight of PDMAEMA is 35 kg / mol, and the polydispersity coefficient is 1.5. Add 0.5 mL of PMAEMA solution dropwise on the surface of the prepared porous film with a respiration pattern, and spin-coat with a desktop homogenizer. The homogenization time I is 6 seconds, the speed is 0.5 thousand rpm, and the homogenization...

Embodiment 2

[0026] Styrene / hydroxyethyl methacrylate block copolymer (PS- b -PHEMA) was dissolved in dichloromethane to prepare 3 mg / mL PS- b -PHEMA solution, PS- b -The molar percentage of styrene units in PHEMA is 99%, and 50 μL of PS- b -The PHEMA solution is evenly spread on the polyimide film, quickly placed in an environment with a relative humidity of 60%, and taken out after the solvent volatilizes to obtain an ordered porous membrane with a respiration pattern, and its pore size is 2.0 μm; the preparation of PDMAEMA Ethanol solution, the concentration is 35 mg / mL, the number average molecular weight of PDMAEMA is 30 kg / mol, and the polydispersity coefficient is 2.0. Add 0.5 mL of PMAEMA solution dropwise on the surface of the prepared porous film with a respiration pattern, and spin-coat with a desktop homogenizer. The homogenization time I is 6 seconds, the speed is 0.5 thousand rpm, and the homogenization time II is 30 seconds. , and the rotating speed was 3,000 r / min to obt...

Embodiment 3

[0028] Styrene / acrylic block copolymer (PS- b -PAA) was dissolved in chloroform to obtain 5 mg / mL PS- b -PAA solution, PS- b -The molar percentage of styrene units in PAA is 95%, and 50 μL of PS- b - The PAA solution is evenly spread on the glassy carbon, quickly placed in an environment with a relative humidity of 70%, and taken out after the solvent volatilizes to obtain an ordered porous membrane with a breath pattern, and its pore size is 2.5 μm; prepare the ethanol solution of PDMAEMA, At a concentration of 25 mg / mL, the number average molecular weight of PDMAEMA is 40 kg / mol and the polydispersity coefficient is 1.8. Add 0.5 mL of PMAEMA solution dropwise on the surface of the prepared porous film with a respiration pattern, and spin-coat with a desktop homogenizer. The homogenization time I is 6 seconds, the speed is 0.5 thousand rpm, and the homogenization time II is 30 seconds. , and the rotating speed was 3,000 r / min to obtain the coated respiration pattern ordere...

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Abstract

The invention discloses a preparation method of a surface enhanced Raman scattering substrate based on a spirogram ordered porous membrane. The method includes the steps of: (1) preparing the spirogram ordered porous membrane; (2) performing spin coating of dimethylaminoethyl methacrylate on the surface of the spirogram ordered porous membrane; (3) placing the spirogram ordered porous membrane in a silver nitrate water solution and a sodium borohydride water solution successively to conduct fixation for certain time; and (4) cleaning the spirogram ordered porous membrane, thus obtaining the surface enhanced Raman scattering substrate based on a spirogram ordered porous membrane and used for detection of probe molecules. The method has the advantages of no need of complex equipment, low cost, simplicity and conveniency, and is applicable to a variety of base materials.

Description

technical field [0001] The invention relates to the field of material chemistry, in particular to a method for preparing a surface-enhanced Raman scattering substrate based on an ordered porous membrane of a breath diagram. Background technique [0002] Raman spectroscopy is a common scattering spectrum used to determine molecular structures, and is widely used in the detection of organic and inorganic substances. However, due to the weak signal intensity of Raman spectroscopy, the detection sensitivity is not high, which significantly limits its application range. Surface-enhanced Raman scattering (SERS) is a technical means that can effectively improve the Raman signal, and its appearance greatly improves the detection sensitivity of Raman spectroscopy. The basis of SERS is to prepare SERS substrates with high sensitivity, good uniformity, repeatability and stability. Patterning can improve the surface roughness and Raman activity of SERS substrates, which is an effectiv...

Claims

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Application Information

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IPC IPC(8): G01N21/65
Inventor 万灵书欧洋王黎阳朱凉伟徐志康
Owner ZHEJIANG UNIV
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