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Amino acid zwitter ion hydrogel material and preparation method thereof

A zwitterion and amino acid technology, applied in the field of functional polymer materials, can solve the problems of high price of zwitterion monomers, complicated preparation methods, expensive phosphorylcholine monomers, etc.

Inactive Publication Date: 2015-07-15
SOUTHEAST UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] Zwitterionic hydrogels are usually obtained by cross-linking polymerization of sulfonic acid or carboxylic acid betaine monomers, or phosphorylcholine monomers and other monomers. The defect of this approach is that various zwitterionic monomers must be synthesized. body, the preparation method is complicated, resulting in high prices of zwitterionic monomers, especially phosphorylcholine monomers are very expensive

Method used

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  • Amino acid zwitter ion hydrogel material and preparation method thereof
  • Amino acid zwitter ion hydrogel material and preparation method thereof

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preparation example Construction

[0040] The preparation method of the amino acid zwitterionic hydrogel material is: glycidyl (meth)acrylate, at least one or more than one polymerizable monomer, at least one or more than one cross-linking agent for the monomer, at least one A polymerizable composition composed of a free radical initiator is polymerized under ultraviolet light or thermal initiation conditions to obtain a cross-linked polymer product, the polymer product is soaked in a solution containing an amino acid or a polypeptide, and further combined with a terminal primary amino group of the amino acid or polypeptide Or the secondary amino group is subjected to an epoxy ring-opening reaction under alkaline conditions of pH 8-14, and the temperature is 30°C to 150°C for 0.5 hours to 3 days to obtain a hydrogel material, and then adjust the pH to about 7, A zwitterionic hydrogel material is obtained. Or further obtain the methylated amino acid zwitterionic hydrogel material by reacting with methyl iodide. ...

example 1

[0062] 2 g of β-hydroxyethyl methacrylate, 1 g of glycidyl methacrylate, 0.015 g of ethylene glycol dimethacrylate, 0.015 g of initiator alkyl aryl ketone Darocur-1173, mix well and inject into the mold In the process, it is cured by ultraviolet light, demolded, soaked and washed, and placed in physiological saline to obtain epoxy hydrogel. The material is optically transparent, with a water content of 25%, a Young's modulus of 1.4MPa, a water contact angle of 78 degrees, and a protein adsorption capacity of 80μg / cm 2 ,RPD 10 35%.

example 2

[0064] Place 2 grams of the epoxy hydrogel in Example 1 in a glycine solution with a concentration of 10%, add sodium hydroxide solution to adjust the pH to 13, heat to 40°C, react for 24 hours, then wash with water, and soak in In a buffer solution with a pH of 7, a glycine zwitterionic hydrogel material is obtained. The material is optically transparent, with a water content of 60%, a water contact angle of 35 degrees, and a protein adsorption capacity of 19 μg / cm 2 .

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Abstract

The invention discloses an amino acid zwitter ion hydrogel material and a preparation method thereof. The amino acid zwitter ion hydrogel material is a product of an epoxy ring-opening reaction of a crosslinked polymer containing epoxy groups and amino acid, amino-acid ester or polypeptide containing primary amine groups or secondary amine groups, and has characteristics of zwitter ions when the pH value is about 7. The preparation method comprises the step of performing the epoxy ring-opening reaction on the crosslinked polymer containing the epoxy groups and the amino acid, amino-acid ester or polypeptide containing the primary amine groups or secondary amine groups under an alkaline condition that the temperature is 30-150 DEG C and the pH value is 8-14. The amino acid zwitter ion hydrogel material has the characteristics of hydrophilic property and bio-adhesion resistance, and can be used as a contact lens, a wound covering material, a tissue repair material, a drug carrier or water absorbent.

Description

technical field [0001] The invention belongs to the technical field of functional polymer materials, and in particular relates to an amino acid zwitterionic hydrogel material, a preparation method and an application thereof. Background technique [0002] Hydrogels are three-dimensional crosslinked network polymer materials containing a large number of water molecules. Polymethacrylate-β-hydroxyethyl methacrylate is the earliest hydrogel material used in medicine. It is mainly used as a contact lens material and has good mechanical properties, optical properties and biocompatibility. However, this material has a low water content of about 38%, has a certain degree of bioadhesion, and is prone to protein and lipid deposition during wearing. [0003] Hydrogel materials can also be used as wound covering materials to maintain a certain degree of humidity in the wound, which is beneficial to wound healing. There are many types of hydrogel wound covering products at home and abr...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08F220/28C08F220/32C08F8/32C08L33/14
Inventor 李新松王杰胡昕
Owner SOUTHEAST UNIV
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