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A kind of hydrogel contact lens and preparation method thereof

A contact lens and hydrogel technology, applied in glasses/goggles, instruments, optics, etc., can solve the problems of poor hydrophilicity, weakened interaction, discomfort, etc., and achieve the effect of high water content

Inactive Publication Date: 2015-08-26
SOUTHEAST UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0011] Due to the close distance between the cation (quaternary ammonium salt) and the anion (sulfonate) in the molecule, the internal salt structure is formed through the direct interaction between the cation and the anion, and the interaction between the cation and the anion and the water molecule is weakened, resulting in the betaine mono The water contact angle of body hydrogel is very high, reaching 70-80 degrees, and the hydrophilicity is poor. This type of monomer is directly used to make contact lenses, and the surface wetting performance is not ideal
[0012] Considering that many hydrogel contact lens wearers report discomfort after wearing them for a day

Method used

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  • A kind of hydrogel contact lens and preparation method thereof
  • A kind of hydrogel contact lens and preparation method thereof
  • A kind of hydrogel contact lens and preparation method thereof

Examples

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preparation example Construction

[0041] The invention discloses a method for preparing a hydrogel contact lens, which is characterized in that the polymerizable composition of sulfobetaine zwitterionic monomer, polymerizable monomer, crosslinking agent, and free radical initiator is initiated by ultraviolet light in a mold Or heat-induced polymerization, and further hydration. The contact lens has the characteristics of high water content, high hydrophilicity, anti-dehydration and anti-protein and lipid deposition. The polymerizable composition may further comprise agents of the group consisting of toners, UV absorbers, colorants, antimicrobial agents.

[0042] A kind of hydrogel contact lens of the present invention and preparation method thereof, the measurement of relevant parameter is according to following method:

[0043] 1. Moisture content

[0044] Soak the contact lens in the preset solution until the swelling balance is reached, then take out the moisture on the surface with filter paper and weigh...

example 1

[0059] Example 1 (comparative example)

[0060] 2.55 grams of β-hydroxyethyl methacrylate, 0.015 grams of ethylene glycol dimethacrylate, 0.015 grams of initiator alkyl aryl ketone Darocur-1173, mix well, inject into the mold, cure with UV light, and release the mold , soaked and washed, and placed in physiological saline to obtain a hydrogel contact lens. The material is optically transparent, with a water content of 38%, a Young's modulus of 1.4MPa, a water contact angle of 78 degrees, and a protein adsorption capacity of 80μg / cm 2 ,RPD 10 35%.

example 2

[0062] 2.40 g of β-hydroxyethyl methacrylate, 0.15 g of dimethylaminoethyl methacrylate-2-hydroxy-propyl sulfonate, 0.01 g of ethylene glycol dimethacrylate, 0.015 g of initiator alkane Aryl ketone Darocur-1173, mixed evenly, poured into a mold, cured by ultraviolet light, demolded, soaked and washed, placed in physiological saline to obtain a hydrogel contact lens. The material is optically transparent, with a water content of 47%, a Young's modulus of 1.2 MPa, a water contact angle of 55 degrees, and a protein adsorption capacity of 36 μg / cm 2 , RPD 10 18%.

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PUM

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Abstract

The invention provides a hydrogel contact lens and a preparation method thereof. The hydrogel contact lens comprises a reacting product of a polymerizable composition, wherein the polymerizable composition contains a hydroxysulfo zwitterionic monomer, at least one or more polymerizable monomers, a crosslinking agent of at least one or more monomers and at least one radical initiator. The hydrogel contact lens is prepared by performing ultraviolet initiation or thermal-initiation polymerization on the hydroxysulfo zwitterionic monomer, the polymerizable monomer, the crosslinking agent and the radical initiator and further hydrating. The contact lens has the characteristics of high water content, high hydrophily, dehydration resistance and protein deposition resistance.

Description

technical field [0001] The invention belongs to the technical field of biomedical polymer materials, and in particular relates to a hydrogel contact lens and a preparation method thereof. Background technique [0002] Polymethacrylate-β-hydroxyethyl methacrylate is the earliest soft contact lens material, which has good mechanical properties, optical properties and biocompatibility. However, this material has a low water content, about 38%, and is prone to protein deposition during wearing. Oxygen permeability is also poor. When worn, oxygen cannot fully pass through the lens material to reach the eyes. Long-term wear will cause insufficient oxygen supply to the eyes, causing eye redness, swelling and discomfort and other related eye diseases. In order to improve the performance of contact lenses, the researchers introduced highly hydrophilic components into the PHEMA gel material to increase the water content. Adding methacrylic acid monomer can increase the water content...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08F220/28C08F220/38C08F220/06C08F230/08C08F220/32C08F220/56C08F230/02G02C7/04
Inventor 李新松樊凯方硕王杰
Owner SOUTHEAST UNIV
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