54 results about "Protein Depositions" patented technology

The invention relates to a model for evaluating the demand amount of dynamically suitable standard ileum digestible Lys of weaned piglets, which comprises a fold-linear model and a fold-linear quadratic model, wherein the fold-linear model is Y = L + U * (R-X), and X is less than R; y = L, X > = R, Y = L + U * (R-X) 2, and X < R; y is equal to L, X is larger than or equal to R, a weaned piglet lysine demand amount dynamic model of weaned piglets with 7-25 kg of weaned piglets or weaned piglets with 20-25 kg of weaned piglets is established, and a weaned piglet dynamic suitable standard ileum digestible Lys demand amount calculated according to the dynamic model is provided. According to the method, the dynamic evaluation model for the lysine demand amount of the weaned piglets is established, the SID lysine demand amount of the weaned piglets is optimized based on ADG, G: F and body protein deposition indexes, the nutritional requirements of the piglets are accurately evaluated, the balance of feeding cost, piglet growth performance and environmental pollution is achieved, and the problems of high feeding cost, environmental pollution and the like are effectively relieved.

The invention relates to a flexible glue material with PCO resistance and application thereof, and provides a flexible glue type IOL material which can be injected, adapts to minimally invasive surgery and has infinite zooming capability and biological resistance, a precursor of the material can be injected into an intraocular capsular bag through an injector, an implanted wound is extremely small, the precursor is crosslinked into flexible glue in situ in the intraocular capsular bag, and the flexible glue can be used as an intraocular material. The performance of natural crystals of young people is simulated, so that the cataract patient recovers the natural regulation function after the operation. The implanted flexible glue has the characteristics of cell adhesion resistance, protein deposition resistance and the like, PCO is avoided, compared with an existing IOL product, the service life is longer, and meanwhile better visual quality is provided for a patient.

The application discloses a kind of anti-blocking mechanism for closed thoracic drainage, including water seal bottle, the bottle mouth end of water seal bottle is equipped with cover, the cover is fixedly connected with connector, the connector is fixedly connected with drainage hard pipe and vent pipe, the drainage hard pipe is connected with drainage hose, this anti-blocking mechanism for closed thoracic drainage effectively solves the connection of original drainage hard pipe and drainage hose and the gravity when drainage material passes, and the soft drainage hard pipe of connection is bent, and then drainage tube is blocked, simultaneously, necrotic material precipitation, protein deposition meat-like drainage material in drainage material, after being drained into water seal bottle, the tube opening of drainage hard pipe inserted in liquid is easily blocked by meat-like drainage material, cannot normally drain, and then cause the patient to appear pneumothorax and other disease problems.

The present invention provides a polyacrylate polymer that resists protein deposition, and a preparation method and application thereof. The blue light filtering intraocular lens device comprises a polyacrylate polymer, which is obtained by polymerizing 5% to 40% by mass of monomer A, 20% to 90% by mass of monomer B, 0% to 30% by mass of monomer C, 0.01% to 2% by mass of zwitterions, 0.05% to 2% by mass of free radical initiators and 1% to 20% by mass of crosslinking agents; the monomer A is at least one acrylic acid, methacrylic acid, acrylate or methacrylate derivative; the monomer B is at least one hydroxyalkyl acrylate or hydroxyalkyl methacrylate derivative; and the monomer C is an ethylene derivative. The present invention copolymerizes specific zwitterions with hydrophobic acrylate monomers to avoid the problem of phase separation during monomer copolymerization and mixing, meets the requirements of hydrophilicity, uniformity, transmittance and hardness of the intraocular lens device, and has high anti-protein and anti-calcification deposition performance.

The invention relates to the technical field of neural computing modeling, in particular to a brain amyloid protein deposition prediction tool suitable for an early Alzheimer patient group. A prediction tool model provided by the invention predicts a brain A beta state in combination with common and high-accessibility clinical indexes on the basis of blood biomarkers; factors possibly influencing BBMs results in clinical practice are fully considered, and the accuracy of the prediction model and the generalizability in the real world are further improved; the model utilizes blood detection and cognitive evaluation, and compared with CSF and PET detection, the model has the advantages of lower cost and invasiveness, so that the model has higher clinical practicability and generalization performance; and an accurate model and a simple model are provided to adapt to different medical conditions and application scenes, so that the practicability and the flexibility of the tool are improved. The model prediction tool provided by the invention carries out training and verification based on national multi-center data, and has good generalization ability.

The present invention discloses a method for removing Aβ 1‑42 The walnut-derived peptide with high antioxidant activity for protein deposition improves learning and memory, and its amino acid sequence is Tyr‑Val‑Tyr‑Tyr‑Pro‑Ser‑Pro‑Lys. The present invention also discloses its use in the preparation of drugs for neuroprotection and improvement of learning and memory, and its use in the preparation of drugs for delaying the occurrence and development of AD. The present invention replaces the leucine at the 3rd and 4th positions of the C-terminus of the original peptide YVLLPSPK with tyrosine to form the derivative peptide YVYYPSPK, which significantly improves its antioxidant activity, thereby having higher neuroprotective activity and improving learning and memory. The derivative peptide YVYYPSPK of the present invention can effectively eliminate Aβ, the early clinical symptom of AD 1‑42 Protein deposition can be used to prevent or delay nerve cell damage, thereby delaying the occurrence and development of AD. It can be used to prepare drugs that delay the occurrence and development of AD, and has huge market potential.

The invention discloses an artificial compound feed for improving collagen deposition of schizothorax grahami and application of the artificial compound feed. The feed additive is characterized in that proline, hydroxyproline, eucommia ulmoides, broad beans and a yeast extract are added, and collagen deposition of the schizothorax grahami is improved under the condition that healthy growth of the schizothorax grahami is not affected. The feed comprises fish meal, fermented soybean meal, soybean protein concentrate, corn protein powder, fish oil, soybean oil, soybean lecithin, alpha-starch, cassava starch, choline chloride, microcrystalline cellulose, compound vitamins, compound minerals, monocalcium phosphate, proline, hydroxyproline, eucommia ulmoides, broad beans, a yeast extract, an antioxidant and a mildew preventive. The feed comprises the following nutritional ingredients in percentage by weight: 40.825%-41.407% of crude protein, 8.132%-8.633% of crude fat, and the balance of carbohydrate, crude fiber, ash and water. According to the artificial compound feed disclosed by the invention, the collagen deposition of the schizothorax grahami is remarkably improved, and the artificial compound feed also has a certain promoting effect on the protein deposition of the schizothorax grahami.

The utility model relates to a kind of nanostructure of laser surface treatment aggregate, wherein the surface of the aggregate is titanium metal, and at least one microchannel with titanium dioxide (TiO2) after cooling is formed by laser melting and sputtering to form molten titanium, at least one microchannel includes: at least one micropore, at least one guide channel, and at least one nano-wall formed at least one nano-bulge layer and at least one nano-wall. The following bone healing and antibacterial index effects and purposes are achieved: A. accelerate bone healing related protein deposition, B. accelerate bone cell attachment, C. induce neovascularization, D. accelerate early calcification and bone mineralization, E. improve nutrient exchange, F. stabilize surface bone structure, and G. resist plaque formation.

The present disclosure provides methods and an apparatus for imaging and analysing images of presumed protein deposits in the retina, retinal tissue or retinal structures and discloses methods differentiating or classifying these deposits and other optical signals from retinal structures into 1) whether they contain or do not contain classes, of proteins or protein deposits called amyloids or other proteins and / or protein deposits related to neurodegenerative eye and brain disease(s): 2) which type(s) of amyloid or other proteins or protein deposits they contain, as well as 3) whether the form and / or properties of the deposit are associated with a class of diseases or with one or another specific condition(s) (or disease(s)); whether or not this is a disease or class of disease associated with the retina or more generally with the nervous system, including the brain or 4) classified as associated with one or another level of severity of condition(s), or disease(s).

The invention discloses a stem cell-negative hydrogen ion compound preparation for treating Alzheimer's disease, and belongs to the technical field of biomedicine, the compound preparation comprises stem cells, a negative hydrogen ion donor, piceatannol glucoside and a pharmaceutically acceptable carrier. Wherein the concentration of the stem cells is 1 * 10 < 6 >-1 * 10 < 8 > / mL, the concentration of the negative hydrogen ion donor is 25-45mg / mL, and the concentration of piceatannol glucoside is 4-8mu g / mL. The composite preparation integrates neural restoration, anti-inflammatory and immunoregulation functions of stem cells, an efficient antioxidant protection effect of a negative hydrogen ion donor and synergistic interaction and safety guarantee effects of piceatannol glucoside. Animal experiments prove that the composite preparation can significantly improve cognitive impairment of Alzheimer's disease model rats and relieve neuroinflammation, oxidative stress and beta-amyloid protein deposition through synergistic anti-inflammatory, anti-oxidation and neuroprotection mechanisms.

The invention discloses an amaranthus hypochondriacus silage total mixed ration formula and a feeding method, and relates to the technical field of silage. Comprising the following raw materials: modified amaranthus hypochondriacus silage stalks, amaranthus hypochondriacus silage leaves, corn silage, alfalfa hay, corn, modified cottonseed meal, soybean meal, wheat bran, a buffering agent, a functional agent, modified attapulgite, a cattle fattening premix, stone powder and table salt. According to the beef cattle feed disclosed by the invention, the added modified grain amaranth silage stalks can reduce the digestion barrier of beef cattle to coarse feed, guarantee the utilization efficiency of daily ration fibers, and avoid the influence on the feed intake and the weight gain effect of the beef cattle due to too high proportion of low-digestion fibers; the added modified cottonseed meal provides crude protein with high utilization rate for beef cattle, and ensures the protein deposition and growth performance of the beef cattle in the fattening period; the added functional agent can inhibit the reproduction of harmful flora, improve the digestion and utilization rate of the whole feed, and guarantee the stability and high efficiency of rumen fermentation.

The invention discloses a silicon hydrogel material as well as a preparation method and application thereof. The preparation method comprises the following steps: curing and molding 2-hydroxyethyl methacrylate (HEMA), 3-(trimethylsiloxy) propyl methacrylate (TRIS), ethylene glycol dimethacrylate (EGDMA), a silane coupling agent and a photoinitiator through a photopolymerization reaction to obtain a silicon hydrogel substrate; performing oxygen plasma treatment; preparing a PDMS hydrophobic layer; performing oxygen plasma treatment; soaking in an organic solution containing a hydrophobic initiator; and forming a hydrophilic polymer layer. The high oxygen permeability, long-acting moisture retention, low friction and protein deposition resistance of the lens are realized by constructing a'hydrophobic water locking-hydrophilic lubrication 'double-layer functional interface.

The invention discloses an acute pneumonia inhibitory ginsenoside Rb1 monomer and application thereof, and relates to the technical field of biological medicines. The ginsenoside Rb1 is screened from a natural product library through a high-throughput screening method, and the ginsenoside Rb1 plays a role in inhibiting expression of inflammatory factors mediated by a menin / SETD2 compound. The monomer can be applied to preparation of anti-inflammatory drugs, anti-tumor drugs, radiotherapy and chemotherapy adjuvant therapy drugs, anti-cytokine storm syndrome (CSS) drugs, lung protection drugs and the like. The compound is applied to drugs for treating acute pneumonia related to inflammatory factor over-activation induced by microbial infection and physical and chemical factors, including inhibition of inflammatory factor expression, reduction of lung tissue inflammatory cell infiltration and pulmonary alveolar protein deposition and the like. The monomer can also effectively inhibit release of lung epithelial cell inflammatory factors induced by ionizing radiation and chemotherapeutic drug exposure. The compound has the advantages of definite action target, high efficiency, specificity, remarkable curative effect, low toxicity and the like.

The invention discloses a method for dynamically predicting the daily ration crude protein demand amount in the fattening stage of Ningxiang pigs, and particularly relates to the technical field of daily ration crude protein demand amount prediction. Comprising the following steps: S1, fitting a growth curve of Ningxiang pigs in a fattening stage; s2, predicting the protein deposition efficiency of the Ningxiang pigs in the fattening stage; and S3, establishing a Ningxiang pig daily ration crude protein intake prediction model based on a factorial method. The Ningxiang pig daily ration crude protein demand quantity dynamic prediction model is established based on the factorial method, and the daily ration crude protein demand quantity can be accurately predicted according to the actual production levels of different farms, so that personalized feed formula preparation is guided. The method can predict the daily ration crude protein demand amount of different Ningxiang pig farms, provides an important technical basis for precise breeding, improves the comprehensive benefits of the farms, and reduces the environmental pollution.

The invention belongs to the technical field of biomedicine and biology, particularly relates to a medicine capable of treating diseases related to protein sedimentation, and particularly discloses a medicine for treating or improving diseases or symptoms related to protein sedimentation, the medicine contains Emc3 protein, and the amino acid sequence of the Emc3 protein is shown as SEQ ID No: 1; the nucleotide sequence of the Emc3 protein is as shown in SEQ ID No: 2. The Emc3 can be used as a target gene for screening and preparing drugs for improving cardiac protein sedimentation, cardiac myocardial cell hypertrophy, cardiac hypertrophy, cardiac failure and the like, reducing death caused by protein deposition and prolonging survival time.

The invention belongs to the technical field of biological medicines, and particularly relates to a novel application of indole-3-methanol or dimer 3, 3 '-diindolylmethane thereof in preparation of medicines for treating muscle degenerative diseases. According to the indole-3-carbinol and the dimer 3, 3 '-diindolylmethane thereof, muscle function decline is obviously delayed, a myofibril structure and a mitochondrial form are protected, and amyloid protein deposition and accumulation are reduced, so that the indole-3-carbinol and the dimer 3, 3'-diindolylmethane thereof play a good role in treating muscle decline related diseases such as sarcopenia and inclusion body myositis. The compound is natural in source and high in safety, can be applied to prevention and treatment of the muscle diseases in forms of oral administration, dietary supplements or pharmaceutical preparations and the like, and has a good industrial application prospect.

The invention discloses a novel therapy for improving the pathological process of Parkinson's disease by using a microbial preparation (Bacteroides maculatus). The application proves that the application of the bacteroides maculatus (B.coprocola) can relieve Parkinson-related motor deficit, alpha-synuclein protein deposition, dopaminergic neuron apoptosis and intestinal flora imbalance, effectively improves the pathological process of Parkinson, and can be used for treating Parkinson's disease, and the application of the bacteroides maculatus (B.coprocola) can be used for treating Parkinson's disease. The composition can maintain the ecological stability of intestinal microorganisms, improve the athletic ability of Parkinson's patients and reduce systemic chronic inflammatory response of Parkinson's patients, and can be used for preventing and / or treating Parkinson's disease.

The present invention discloses a walnut-derived peptide with high antioxidant ability to clear Aβ and improve learning and memory, and its amino acid sequence is Tyr‑Val‑Leu‑Tyr‑Pro‑Ser‑Pro‑Lys. The present invention also discloses its use in the preparation of drugs for neuroprotection and improvement of learning and memory, and its use in the preparation of drugs for delaying the occurrence and development of AD. The present invention replaces the leucine at the 4th position of the C-terminus of the original peptide YVLLPSPK with tyrosine to form a derivative peptide YVLYPSPK, which significantly improves its antioxidant activity, thereby having higher neuroprotective activity and improving learning and memory. The derivative peptide YVLYPSPK of the present invention can effectively clear Aβ, a preclinical symptom of AD 1‑42 Protein deposition can be used to prevent or delay nerve cell damage, thereby delaying the occurrence and development of AD. It can be used to prepare drugs that delay the occurrence and development of AD, and has huge market potential.

The invention discloses a feed for promoting piglet growth and protein deposition, and belongs to the technical field of animal nutrition. The feed is a complete formula feed with the standard ileum digestible protein level of 13.2%-16.4%, and contains 0.1%-1.0% of a composite functional additive. The additive is composed of 10%-30% of coated sodium butyrate, 5%-15% of a lactobacillus probiotic preparation, 3%-10% of yeast beta-glucan, 2%-8% of a nucleotide mixture, 8%-20% of glutamine, 1%-5% of acid protease and a carrier. Through the synergistic effect of the additive and the low-protein daily ration, the intestinal health, nutrient substance digestion and absorption and immune states of piglets are comprehensively improved, so that the technical effects of improving the feed efficiency, promoting body protein deposition and reducing the diarrhea rate are achieved while the protein level of the daily ration is reduced and the cost is saved.

The invention provides a hyaluronic acid contact lens nano-composite coating and a preparation method thereof, and belongs to the technical field of contact lenses. The composite coating is a contact lens coating based on hyaluronic acid and a nano composite material, through a covalent cross-linking and physical adsorption dual mechanism, hyaluronic acid provides a continuous hydration effect to prevent lens drying, hyaluronic acid and nano cellulose synergistically lock water, and long-acting moisturizing is realized; the PDA nano-particles are recombined after being wetted, the hydrophilicity is recovered, and the wettability is improved; the nano composite layer forms a physical barrier, tear protein adsorption is reduced, and the protein deposition resisting effect is improved; the coating has self-repairing capability, can recover hydrophilicity after blinking or wetting by eye drops, and has repeatable wettability. The composite coating provided by the invention is suitable for soft contact lenses for daily polishing, moon polishing and the like.

A contact lens and a method of manufacturing the same are provided. The contact lens includes a contact lens body and a blue light blocking material covering the contact lens body. The blue light blocking material includes a plurality of metal particles dispersed on the contact lens body. The present invention includes compositions of at least one compound including metal ion with at least one or more reducing factors. The interactions between reducing factors endow contact lens body with homogeneous or pupil-regional preference of metal particles distribution with enhanced or decreased efficacy of blue light blocking. A further modification strengthens surface properties of contact lens including contact angle, water break-up time and long-term protein depositions.

The invention provides a penaeus vannamei protein deposition accelerant and penaeus vannamei feed, and belongs to the technical field of feed additives, the penaeus vannamei protein deposition accelerant provided by the invention comprises a small peptide composition with the molecular weight of 150-1500Da, and the small peptide composition is formed by compounding a marine protein enzymolysis product and a plant protein enzymolysis product. The feed provided by the invention can effectively improve the food calling property of the penaeus vannamei boone, increase the digestible energy of the feed, improve the intestinal morphology of the penaeus vannamei boone, improve the protein utilization rate of the penaeus vannamei boone and effectively increase the yield of the penaeus vannamei boone.

The invention belongs to the technical field of care solutions, and provides an anti-proteolysis contact lens care solution based on a nanotechnology. The protein deposition resistant contact lens care solution based on the nanotechnology is prepared from sulphobetaine, nano-liposome, hyaluronic acid, a complexing agent, an antibacterial agent, a pH regulator, an osmotic pressure regulator and water. The mass percent of each raw material is limited. The nano lipidosome with a core-shell structure is introduced, and the nutritional component is the core material, so that the nano lipidosome has the effects of resisting oxidation and relieving fatigue; the shell material is nano-liposome modified by alkyl glycoside and has excellent hydrophilicity; the nano-liposome, the sulphobetaine and the hyaluronic acid have a synergistic effect, so that the deposition of protein is destroyed; the complexing agent and metal ions form a complex, so that the metal ions are prevented from participating in protein deposition, and protein deposition is further prevented and reduced; the nanotechnology is successfully applied to moisturizing / lubricating components, protein deposition can be synergistically prevented, and the comfort of long-time wearing is improved.

The invention relates to an A beta-PET brain template construction and quantitative analysis method based on deep learning, and the method comprises the steps: obtaining a PET image preprocessed by a normal participant, namely, an A beta-PET image; performing spatial registration to MNI152, and performing intensity normalization processing, data screening and average calculation to obtain a preliminary A beta-PET brain template image; the screened A beta-PET image is registered to a preliminary A beta-PET brain template image, and a final A beta-PET brain template image is obtained through intensity normalization processing, data screening, average calculation and smoothing processing; calculating a first quantitative parameter to construct a brain amyloid protein deposition data database; and performing spatial registration on the A beta-PET image to be analyzed to the final A beta-PET brain template image, dividing a brain region, calculating a second quantitative parameter, and comparing the second quantitative parameter with the brain amyloid protein deposition data database to complete quantitative analysis. The method has the beneficial effects that a normal A beta-PET brain template data database is established, a matched quantitative amyloid protein deposition analysis process is provided for clinical use, and the registration effect and the diagnosis and treatment efficiency are improved.

The invention relates to an application of a GPE analogue or a pharmaceutically acceptable derivative thereof in preparation of a medicine for preventing and / or treating Alzheimer's disease (AD). Experiments prove that the GPE analogue can significantly improve cognitive impairment of mice with AD diseases and significantly improve cognitive competence of the mice for the first time; furthermore, the inventor researches the pathological mechanism of the GPE analogue to find that the GPE analogue can obviously reduce beta-amyloid protein deposition in cerebral cortex and hippocampus, so that the toxicity of the GPE analogue to nerve cells is obviously reduced, and therefore, the GPE analogue can be used for preventing, relieving, improving or treating the AD disease or delaying the progress of the AD disease, and has a good application prospect. The compound is expected to become a candidate therapeutic drug for Alzheimer's disease, and has great clinical application prospect and value.

The invention belongs to the technical field of biological medicines, and discloses a composite targeted drug for targeted alleviation of Alzheimer's disease, in a single preparation, the active components comprise 5-10 mg of TAU protein precursor and 5-20 mg of lithium orotate, and a medicinal carrier is supplemented to prepare the composite targeted drug for targeted alleviation of Alzheimer's disease. The medicinal carrier comprises a targeted delivery material TAU protein precursor, and one or more of a filler, a disintegrating agent and an adhesive. According to the medicine, by means of the blood-brain barrier penetrating capacity and targeting of TAU protein precursors and in combination with the neuron metabolism regulation effect of lithium orotate, multi-mechanism synergistic treatment is achieved, targeting and bioavailability are improved, beta-amyloid protein deposition and nerve fiber tangling can be effectively reduced, the neuron function is improved, the treatment effect is excellent, and safety is good.

The disclosure relates to a system comprising software that predicts responsiveness of healthy subjects or subjects at risk for or suffering from Alzheimer's Disease to certain disease modifying drugs. Embodiments of the disclosure include methods comprising analyzing images of the brain for depositions of amyloid-beta (Aβ) protein and tau protein, and correlating protein deposition levels to drug responsiveness.

The present invention relates to an MRI-CEST polypeptide probe, imaging method and equipment for targeting and identifying abnormal α-synuclein in the brain of Parkinson's disease. The sequence of the polypeptide probe is: TFFYGGSRGKRNNNKTEEY. The implementation of the equipment includes the following steps: (1) using Fmoc solid phase to synthesize the targeted polypeptide probe; (2) the targeted polypeptide probe binds to abnormal α-synuclein in the brain, taking into account high-quality CEST signals; (3) the MRI-CEST sequence is used to collect brain images of Parkinson's rats, and the images before and after the injection of the polypeptide probe are collected respectively, and the abnormal α-synuclein deposition in the model brain is evaluated in a non-invasive and radiation-free method; (4) the collected images are post-processed by Matlab, and the protein deposition is semi-quantitatively evaluated. The present invention is expected to improve the accuracy of early diagnosis of PD.

The present disclosure provides methods and an apparatus for imaging and analysing images of presumed protein deposits in the retina, retinal tissue or retinal structures and discloses methods differentiating or classifying these deposits and other optical signals from retinal structures into 1) whether they contain or do not contain classes, of proteins or protein deposits called amyloids or other proteins and / or protein deposits related to neurodegenerative eye and brain disease(s); 2) which type(s) of amyloid or other proteins or protein deposits they contain, as well as 3) whether the form and / or properties of the deposit are associated with a class of diseases or with one or another specific condition(s) (or disease(s)); whether or not this is a disease or class of disease associated with the retina or more generally with the nervous system, including the brain or 4) classified as associated with one or another level of severity of condition(s), or disease(s).

The invention discloses a pig growth prediction method based on all-organism computing power and biochemical antagonism correction, which comprises the following steps: acquiring pig growth related data and carrying out data preprocessing to obtain a standard data set; according to the standard data set, effective net energy is calculated by adopting a host-microorganism double-track system model; according to the effective net energy, dynamically adjusting the bio-availability of the nutrients through a biochemical antagonism correction mechanism to obtain corrected nutrient data; according to the corrected nutrient data, enforced fat energy distribution logic and multi-factor limitation arbitration are executed, and the final protein deposition amount and fat deposition amount are determined; according to the final protein deposition amount and fat deposition amount, pig growth performance parameters are predicted, and a pig growth prediction result is obtained. According to the method, digital twinborn simulation and high-precision prediction of the growth performance of the pigs in a complex nutrition environment and under an atypical feeding condition are realized.