27 results about "Protein Depositions" patented technology

The application discloses a kind of anti-blocking mechanism for closed thoracic drainage, including water seal bottle, the bottle mouth end of water seal bottle is equipped with cover, the cover is fixedly connected with connector, the connector is fixedly connected with drainage hard pipe and vent pipe, the drainage hard pipe is connected with drainage hose, this anti-blocking mechanism for closed thoracic drainage effectively solves the connection of original drainage hard pipe and drainage hose and the gravity when drainage material passes, and the soft drainage hard pipe of connection is bent, and then drainage tube is blocked, simultaneously, necrotic material precipitation, protein deposition meat-like drainage material in drainage material, after being drained into water seal bottle, the tube opening of drainage hard pipe inserted in liquid is easily blocked by meat-like drainage material, cannot normally drain, and then cause the patient to appear pneumothorax and other disease problems.

The utility model relates to a kind of nanostructure of laser surface treatment aggregate, wherein the surface of the aggregate is titanium metal, and at least one microchannel with titanium dioxide (TiO2) after cooling is formed by laser melting and sputtering to form molten titanium, at least one microchannel includes: at least one micropore, at least one guide channel, and at least one nano-wall formed at least one nano-bulge layer and at least one nano-wall. The following bone healing and antibacterial index effects and purposes are achieved: A. accelerate bone healing related protein deposition, B. accelerate bone cell attachment, C. induce neovascularization, D. accelerate early calcification and bone mineralization, E. improve nutrient exchange, F. stabilize surface bone structure, and G. resist plaque formation.

The invention discloses a stem cell-negative hydrogen ion compound preparation for treating Alzheimer's disease, and belongs to the technical field of biomedicine, the compound preparation comprises stem cells, a negative hydrogen ion donor, piceatannol glucoside and a pharmaceutically acceptable carrier. Wherein the concentration of the stem cells is 1 * 10 < 6 >-1 * 10 < 8 > / mL, the concentration of the negative hydrogen ion donor is 25-45mg / mL, and the concentration of piceatannol glucoside is 4-8mu g / mL. The composite preparation integrates neural restoration, anti-inflammatory and immunoregulation functions of stem cells, an efficient antioxidant protection effect of a negative hydrogen ion donor and synergistic interaction and safety guarantee effects of piceatannol glucoside. Animal experiments prove that the composite preparation can significantly improve cognitive impairment of Alzheimer's disease model rats and relieve neuroinflammation, oxidative stress and beta-amyloid protein deposition through synergistic anti-inflammatory, anti-oxidation and neuroprotection mechanisms.

The invention discloses an amaranthus hypochondriacus silage total mixed ration formula and a feeding method, and relates to the technical field of silage. Comprising the following raw materials: modified amaranthus hypochondriacus silage stalks, amaranthus hypochondriacus silage leaves, corn silage, alfalfa hay, corn, modified cottonseed meal, soybean meal, wheat bran, a buffering agent, a functional agent, modified attapulgite, a cattle fattening premix, stone powder and table salt. According to the beef cattle feed disclosed by the invention, the added modified grain amaranth silage stalks can reduce the digestion barrier of beef cattle to coarse feed, guarantee the utilization efficiency of daily ration fibers, and avoid the influence on the feed intake and the weight gain effect of the beef cattle due to too high proportion of low-digestion fibers; the added modified cottonseed meal provides crude protein with high utilization rate for beef cattle, and ensures the protein deposition and growth performance of the beef cattle in the fattening period; the added functional agent can inhibit the reproduction of harmful flora, improve the digestion and utilization rate of the whole feed, and guarantee the stability and high efficiency of rumen fermentation.

The invention discloses a silicon hydrogel material as well as a preparation method and application thereof. The preparation method comprises the following steps: curing and molding 2-hydroxyethyl methacrylate (HEMA), 3-(trimethylsiloxy) propyl methacrylate (TRIS), ethylene glycol dimethacrylate (EGDMA), a silane coupling agent and a photoinitiator through a photopolymerization reaction to obtain a silicon hydrogel substrate; performing oxygen plasma treatment; preparing a PDMS hydrophobic layer; performing oxygen plasma treatment; soaking in an organic solution containing a hydrophobic initiator; and forming a hydrophilic polymer layer. The high oxygen permeability, long-acting moisture retention, low friction and protein deposition resistance of the lens are realized by constructing a'hydrophobic water locking-hydrophilic lubrication 'double-layer functional interface.

The invention discloses a method for dynamically predicting the daily ration crude protein demand amount in the fattening stage of Ningxiang pigs, and particularly relates to the technical field of daily ration crude protein demand amount prediction. Comprising the following steps: S1, fitting a growth curve of Ningxiang pigs in a fattening stage; s2, predicting the protein deposition efficiency of the Ningxiang pigs in the fattening stage; and S3, establishing a Ningxiang pig daily ration crude protein intake prediction model based on a factorial method. The Ningxiang pig daily ration crude protein demand quantity dynamic prediction model is established based on the factorial method, and the daily ration crude protein demand quantity can be accurately predicted according to the actual production levels of different farms, so that personalized feed formula preparation is guided. The method can predict the daily ration crude protein demand amount of different Ningxiang pig farms, provides an important technical basis for precise breeding, improves the comprehensive benefits of the farms, and reduces the environmental pollution.

The invention belongs to the technical field of biomedicine and biology, particularly relates to a medicine capable of treating diseases related to protein sedimentation, and particularly discloses a medicine for treating or improving diseases or symptoms related to protein sedimentation, the medicine contains Emc3 protein, and the amino acid sequence of the Emc3 protein is shown as SEQ ID No: 1; the nucleotide sequence of the Emc3 protein is as shown in SEQ ID No: 2. The Emc3 can be used as a target gene for screening and preparing drugs for improving cardiac protein sedimentation, cardiac myocardial cell hypertrophy, cardiac hypertrophy, cardiac failure and the like, reducing death caused by protein deposition and prolonging survival time.

The invention discloses a novel therapy for improving the pathological process of Parkinson's disease by using a microbial preparation (Bacteroides maculatus). The application proves that the application of the bacteroides maculatus (B.coprocola) can relieve Parkinson-related motor deficit, alpha-synuclein protein deposition, dopaminergic neuron apoptosis and intestinal flora imbalance, effectively improves the pathological process of Parkinson, and can be used for treating Parkinson's disease, and the application of the bacteroides maculatus (B.coprocola) can be used for treating Parkinson's disease. The composition can maintain the ecological stability of intestinal microorganisms, improve the athletic ability of Parkinson's patients and reduce systemic chronic inflammatory response of Parkinson's patients, and can be used for preventing and / or treating Parkinson's disease.

A contact lens and a method of manufacturing the same are provided. The contact lens includes a contact lens body and a blue light blocking material covering the contact lens body. The blue light blocking material includes a plurality of metal particles dispersed on the contact lens body. The present invention includes compositions of at least one compound including metal ion with at least one or more reducing factors. The interactions between reducing factors endow contact lens body with homogeneous or pupil-regional preference of metal particles distribution with enhanced or decreased efficacy of blue light blocking. A further modification strengthens surface properties of contact lens including contact angle, water break-up time and long-term protein depositions.

The invention provides a penaeus vannamei protein deposition accelerant and penaeus vannamei feed, and belongs to the technical field of feed additives, the penaeus vannamei protein deposition accelerant provided by the invention comprises a small peptide composition with the molecular weight of 150-1500Da, and the small peptide composition is formed by compounding a marine protein enzymolysis product and a plant protein enzymolysis product. The feed provided by the invention can effectively improve the food calling property of the penaeus vannamei boone, increase the digestible energy of the feed, improve the intestinal morphology of the penaeus vannamei boone, improve the protein utilization rate of the penaeus vannamei boone and effectively increase the yield of the penaeus vannamei boone.

The invention relates to an A beta-PET brain template construction and quantitative analysis method based on deep learning, and the method comprises the steps: obtaining a PET image preprocessed by a normal participant, namely, an A beta-PET image; performing spatial registration to MNI152, and performing intensity normalization processing, data screening and average calculation to obtain a preliminary A beta-PET brain template image; the screened A beta-PET image is registered to a preliminary A beta-PET brain template image, and a final A beta-PET brain template image is obtained through intensity normalization processing, data screening, average calculation and smoothing processing; calculating a first quantitative parameter to construct a brain amyloid protein deposition data database; and performing spatial registration on the A beta-PET image to be analyzed to the final A beta-PET brain template image, dividing a brain region, calculating a second quantitative parameter, and comparing the second quantitative parameter with the brain amyloid protein deposition data database to complete quantitative analysis. The method has the beneficial effects that a normal A beta-PET brain template data database is established, a matched quantitative amyloid protein deposition analysis process is provided for clinical use, and the registration effect and the diagnosis and treatment efficiency are improved.

The invention belongs to the technical field of biological medicines, and discloses a composite targeted drug for targeted alleviation of Alzheimer's disease, in a single preparation, the active components comprise 5-10 mg of TAU protein precursor and 5-20 mg of lithium orotate, and a medicinal carrier is supplemented to prepare the composite targeted drug for targeted alleviation of Alzheimer's disease. The medicinal carrier comprises a targeted delivery material TAU protein precursor, and one or more of a filler, a disintegrating agent and an adhesive. According to the medicine, by means of the blood-brain barrier penetrating capacity and targeting of TAU protein precursors and in combination with the neuron metabolism regulation effect of lithium orotate, multi-mechanism synergistic treatment is achieved, targeting and bioavailability are improved, beta-amyloid protein deposition and nerve fiber tangling can be effectively reduced, the neuron function is improved, the treatment effect is excellent, and safety is good.

The disclosure relates to a system comprising software that predicts responsiveness of healthy subjects or subjects at risk for or suffering from Alzheimer's Disease to certain disease modifying drugs. Embodiments of the disclosure include methods comprising analyzing images of the brain for depositions of amyloid-beta (Aβ) protein and tau protein, and correlating protein deposition levels to drug responsiveness.

The present disclosure provides methods and an apparatus for imaging and analysing images of presumed protein deposits in the retina, retinal tissue or retinal structures and discloses methods differentiating or classifying these deposits and other optical signals from retinal structures into 1) whether they contain or do not contain classes, of proteins or protein deposits called amyloids or other proteins and / or protein deposits related to neurodegenerative eye and brain disease(s); 2) which type(s) of amyloid or other proteins or protein deposits they contain, as well as 3) whether the form and / or properties of the deposit are associated with a class of diseases or with one or another specific condition(s) (or disease(s)); whether or not this is a disease or class of disease associated with the retina or more generally with the nervous system, including the brain or 4) classified as associated with one or another level of severity of condition(s), or disease(s).

The invention discloses a pig growth prediction method based on all-organism computing power and biochemical antagonism correction, which comprises the following steps: acquiring pig growth related data and carrying out data preprocessing to obtain a standard data set; according to the standard data set, effective net energy is calculated by adopting a host-microorganism double-track system model; according to the effective net energy, dynamically adjusting the bio-availability of the nutrients through a biochemical antagonism correction mechanism to obtain corrected nutrient data; according to the corrected nutrient data, enforced fat energy distribution logic and multi-factor limitation arbitration are executed, and the final protein deposition amount and fat deposition amount are determined; according to the final protein deposition amount and fat deposition amount, pig growth performance parameters are predicted, and a pig growth prediction result is obtained. According to the method, digital twinborn simulation and high-precision prediction of the growth performance of the pigs in a complex nutrition environment and under an atypical feeding condition are realized.

The application discloses application of BAY 11-7085 in preventing and treating pneumonia. In the application, it is found through actual administration test of a model mouse that BAY 11-7085 can significantly reduce expression of inflammatory factors and protein content in alveolar lavage fluid, reduce a lung pathology score, thereby treating pneumonia, and effectively relieving or inhibiting alveolar protein deposition, pulmonary edema and death caused by pneumonia.

The application discloses a superparamagnetic nanomedicine targeting an Alzheimer's disease A beta protein pathological area and a preparation method and application thereof, and a structure of the superparamagnetic nanomedicine targeting the Alzheimer's disease A beta protein pathological area is Fe3O4-HS-PEG 600 -CO-NH2 complex polypeptide; the complex polypeptide is composed of a targeting A beta protein locating sequence, a transmembrane sequence, a Sema3A inhibiting peptide and a nerve protection peptide in sequence from N to C; the targeting A beta protein locating sequence is FFXXK. The application can effectively reduce hippocampal A beta protein deposition plaques by reducing the introduction of the Sema3A inhibiting peptide and the nerve protection peptide in the Alzheimer's disease A beta protein deposition pathological area, is beneficial to the repair of hippocampal nerve networks, and has great potential for treating Alzheimer's disease.

A soft gel material having anti-PCO properties and the use thereof. Provided is a "soft gel-type IOL material" that has injectability, suitability for minimally invasive surgery, a stepless zooming capability and biological resistance. A precursor of the material can be injected into an intraocular capsular bag by means of a syringe, resulting in an extremely small implantation incision, and then undergoes in-situ cross-linking into a soft gel in the intraocular capsular bag, mimicking the performance of a natural crystalline lens in young people, thereby enabling cataract patients to regain natural accommodation function after surgery. The implanted soft gel has properties such as anti-cell adhesion and anti-protein deposition, which prevent the occurrence of PCO. Compared with existing IOL products, the implanted soft gel has a longer service life while providing patients with better visual quality.

A contact lens and a method of manufacturing the same are provided. The contact lens includes a contact lens body and a blue light blocking material covering the contact lens body. The blue light blocking material includes a plurality of metal particles dispersed on the contact lens body. The present invention includes compositions of at least one compound including metal ion with at least one or more reducing factors. The interactions between reducing factors endow contact lens body with homogeneous or pupil-regional preference of metal particles distribution with enhanced or decreased efficacy of blue light blocking. A further modification strengthens surface properties of contact lens including contact angle, water break-up time and long-term protein depositions.

This invention discloses a bicyclic compound, its intermediate, a preparation method, and its applications. Specifically, it discloses a compound as shown in Formula I, and its pharmaceutically acceptable salt or isotope. The compound of this invention exhibits good binding ability to amyloid protein, a short half-life, and good imaging effect. Furthermore, the compound of this invention can be used to prepare positron emission tomography (PET) agents and can be used for the early diagnosis of amyloid protein deposition-related diseases, such as Alzheimer's disease, and for monitoring the efficacy of drugs.

The application discloses a kind of based on KH-550 modified composite phase change hemostatic material and its preparation method and application;The composite phase change hemostatic material is made of sodium-based montmorillonite nanoparticles, KH-550, 1,6-hexanediol;Among them, KH-550, 1,6-hexanediol is grafted on the surface of sodium-based montmorillonite nanoparticles by hydrogen bond and covalent bond;KH-550 modified sodium-based montmorillonite provides adsorption and coagulation platform, 1,6-hexanediol is used to adjust the hydrogen bond network, forming property and phase change property of composite system, and further introduce polyphenol functional components to enhance the tissue adhesion and protein deposition capacity of the material;The material has the advantages of rapid hemostasis, good wound adhesion, strong dosage form adaptability, good biocompatibility, antibacterial and anti-inflammatory and promoting wound healing, etc., can be prepared into hemostatic powder, hemostatic sponge, hemostatic film, hemostatic gel or hemostatic dressing, and is suitable for surface and internal wound hemostasis.

This invention discloses a traditional Chinese medicine composition for the prevention, mitigation, or treatment of Alzheimer's disease, comprising 8-12 parts of Cistanche deserticola, 8-12 parts of Polygonatum sibiricum, 8-12 parts of Panax ginseng, 12-18 parts of Astragalus membranaceus, 12-18 parts of Angelica sinensis, 12-18 parts of Ligustrum lucidum, 8-12 parts of Salvia miltiorrhiza, and 8-10 parts of Panax notoginseng, all by weight. The traditional Chinese medicine composition of this invention significantly improves Alzheimer's disease-related symptoms in a mouse model of Alzheimer's disease, including the novel object recognition index, Y-maze spatial cognition index, water maze activity index, number and distribution of Nissl bodies in neurons, and β-amyloid protein deposition. It is expected to effectively prevent, mitigate, or improve different stages of Alzheimer's disease and its related complications and underlying diseases.

The application belongs to the technical field of biology, and discloses application of pyroglutamic acid in preparation of a muscle increasing product, and finds a new use of pyroglutamic acid; animal experiment results show that 0.2% of the addition amount of pyroglutamic acid is supplemented through water for 15 weeks, which can significantly increase the gastrocnemius muscle, tibialis anterior muscle and soleus muscle weight of ordinary feeding mice, increase the muscle fiber cross-sectional area and improve the exercise capacity, and indicates that pyroglutamic acid can promote the growth and development of skeletal muscle and improve the function of skeletal muscle. Through gene and protein level analysis, it is known that pyroglutamic acid can promote the expression of genes and proteins related to protein deposition in the tibialis anterior muscle, thereby realizing muscle increase. Meanwhile, the application also discloses a product for muscle increase.

The invention provides an artificial compound feed for improving collagen deposition of schizothorax grahami, and belongs to the field of fish feeds. The artificial compound feed comprises the following raw materials: an animal protein source raw material, a plant protein source raw material, a fat source raw material, a sugar source, a premix and auxiliary materials, the premix is a mixture of eucommia ulmoides, broad beans, a yeast extract, proline and hydroxyproline. Through the synergistic effect of the premix and the basic raw materials, the collagen and protein deposition of the schizothorax grahami are improved. In the premix, the proline and the hydroxyproline provide key amino acid raw materials for collagen synthesis, the eucommia ulmoides and the broad beans activate a muscle collagen synthesis pathway, and the yeast extract promotes absorption of functional components and jointly promotes collagen accumulation. In the basic raw materials, animal and plant protein sources provide comprehensive essential amino acids, and sufficient raw materials are provided for protein synthesis; the sugar source provides energy, so that protein is prevented from being decomposed for energy supply; the yeast extract also improves the digestion and utilization rate of protein raw materials, and assists whole-fish protein deposition.

The invention belongs to the technical field of medical instruments, and particularly relates to a preparation method of a coating capable of enabling the inner surface and the outer surface of a stent to have different antithrombotic performance, which comprises the following steps: (1) preparation of a coating solution: mixing a polymer and a solvent to obtain the coating solution; (2) coating preparation: attaching the coating solution to the surface of the stent; and (3) inducing beta phase change: performing corona polarization treatment on the stent obtained in the step (2), so that the outer surface of the stent is positively charged, and the inner surface of the stent is negatively charged. According to the preparation method, a coating with a piezoelectric effect can be formed on the surface of the stent, so that negative potential can be generated on the inner surface of the stent and positive potential can be generated on the outer surface of the stent under the conditions of contact with a blood vessel wall and blood flow impact pressure, and the inner surface of the stent has anti-thrombus capability; fibrous protein deposition occurs at the position where the outer surface of the stent is in contact with a tumor neck opening, the tumor neck opening is rapidly closed, and the artery hemangioma is closed.

The utility model relates to the field of contact lenses, and discloses a contact lens structure capable of improving tear film stability, which comprises a first coating film and a second coating film with nanoscale thickness, the second coating film is wrapped on the first coating film, the first coating film is attached to a contact lens main body, the first coating film is an inner hydrophobic layer, and the second coating film is an outer hydrophobic layer. The second coating film is an external hydrophilic layer; the edge of the first coating film is provided with a continuous bulge, the edge of the second coating film is provided with a double-arch structure which is matched with the continuous bulge in shape, a gap capable of containing tears is formed in the center of the double-arch structure, and the tears in the gap flow out when the first coating film is in a pressed state. According to the utility model, the rapid circulation of tears is realized, the protein deposition condition is reduced, the evaporation condition of moisture in the tears can be reduced, the osmotic pressure of a tear film is ensured, and the stability of the tear film is maintained.

The invention relates to application of a compound ZJF shown in the following formula or pharmaceutically acceptable salt thereof in preparation of a product for treating and / or preventing Alzheimer's disease, and belongs to the field of medicine. The compound ZJF provided by the invention can significantly improve abnormal reduction of proliferation of hippocampus neural stem cells caused by Alzheimer's disease, improve abnormal reduction of generation of new neurons of hippocampus caused by Alzheimer's disease, and significantly inhibit Abeta amyloid protein deposition in hippocampus; the excessive phosphorylation of the Tau protein in the hippocampus region is obviously inhibited; the abnormal activation of microglial cells is obviously inhibited. The compound ZJF provided by the invention can be used for preparing medicines or medicinal preparations for treating and / or preventing learning and memory impairment, cognitive dysfunction and / or depression caused by Alzheimer's disease.