5 results about "Protein Depositions" patented technology

The application discloses a superparamagnetic nanomedicine targeting an Alzheimer's disease A beta protein pathological area and a preparation method and application thereof, and a structure of the superparamagnetic nanomedicine targeting the Alzheimer's disease A beta protein pathological area is Fe3O4-HS-PEG 600 -CO-NH2 complex polypeptide; the complex polypeptide is composed of a targeting A beta protein locating sequence, a transmembrane sequence, a Sema3A inhibiting peptide and a nerve protection peptide in sequence from N to C; the targeting A beta protein locating sequence is FFXXK. The application can effectively reduce hippocampal A beta protein deposition plaques by reducing the introduction of the Sema3A inhibiting peptide and the nerve protection peptide in the Alzheimer's disease A beta protein deposition pathological area, is beneficial to the repair of hippocampal nerve networks, and has great potential for treating Alzheimer's disease.

This invention discloses a bicyclic compound, its intermediate, a preparation method, and its applications. Specifically, it discloses a compound as shown in Formula I, and its pharmaceutically acceptable salt or isotope. The compound of this invention exhibits good binding ability to amyloid protein, a short half-life, and good imaging effect. Furthermore, the compound of this invention can be used to prepare positron emission tomography (PET) agents and can be used for the early diagnosis of amyloid protein deposition-related diseases, such as Alzheimer's disease, and for monitoring the efficacy of drugs.

This invention discloses a traditional Chinese medicine composition for the prevention, mitigation, or treatment of Alzheimer's disease, comprising 8-12 parts of Cistanche deserticola, 8-12 parts of Polygonatum sibiricum, 8-12 parts of Panax ginseng, 12-18 parts of Astragalus membranaceus, 12-18 parts of Angelica sinensis, 12-18 parts of Ligustrum lucidum, 8-12 parts of Salvia miltiorrhiza, and 8-10 parts of Panax notoginseng, all by weight. The traditional Chinese medicine composition of this invention significantly improves Alzheimer's disease-related symptoms in a mouse model of Alzheimer's disease, including the novel object recognition index, Y-maze spatial cognition index, water maze activity index, number and distribution of Nissl bodies in neurons, and β-amyloid protein deposition. It is expected to effectively prevent, mitigate, or improve different stages of Alzheimer's disease and its related complications and underlying diseases.

The application belongs to the technical field of biology, and discloses application of pyroglutamic acid in preparation of a muscle increasing product, and finds a new use of pyroglutamic acid; animal experiment results show that 0.2% of the addition amount of pyroglutamic acid is supplemented through water for 15 weeks, which can significantly increase the gastrocnemius muscle, tibialis anterior muscle and soleus muscle weight of ordinary feeding mice, increase the muscle fiber cross-sectional area and improve the exercise capacity, and indicates that pyroglutamic acid can promote the growth and development of skeletal muscle and improve the function of skeletal muscle. Through gene and protein level analysis, it is known that pyroglutamic acid can promote the expression of genes and proteins related to protein deposition in the tibialis anterior muscle, thereby realizing muscle increase. Meanwhile, the application also discloses a product for muscle increase.