39 results about "Protein Depositions" patented technology

The application discloses a kind of anti-blocking mechanism for closed thoracic drainage, including water seal bottle, the bottle mouth end of water seal bottle is equipped with cover, the cover is fixedly connected with connector, the connector is fixedly connected with drainage hard pipe and vent pipe, the drainage hard pipe is connected with drainage hose, this anti-blocking mechanism for closed thoracic drainage effectively solves the connection of original drainage hard pipe and drainage hose and the gravity when drainage material passes, and the soft drainage hard pipe of connection is bent, and then drainage tube is blocked, simultaneously, necrotic material precipitation, protein deposition meat-like drainage material in drainage material, after being drained into water seal bottle, the tube opening of drainage hard pipe inserted in liquid is easily blocked by meat-like drainage material, cannot normally drain, and then cause the patient to appear pneumothorax and other disease problems.

The invention discloses an artificial compound feed for improving collagen deposition of schizothorax grahami and application of the artificial compound feed. The feed additive is characterized in that proline, hydroxyproline, eucommia ulmoides, broad beans and a yeast extract are added, and collagen deposition of the schizothorax grahami is improved under the condition that healthy growth of the schizothorax grahami is not affected. The feed comprises fish meal, fermented soybean meal, soybean protein concentrate, corn protein powder, fish oil, soybean oil, soybean lecithin, alpha-starch, cassava starch, choline chloride, microcrystalline cellulose, compound vitamins, compound minerals, monocalcium phosphate, proline, hydroxyproline, eucommia ulmoides, broad beans, a yeast extract, an antioxidant and a mildew preventive. The feed comprises the following nutritional ingredients in percentage by weight: 40.825%-41.407% of crude protein, 8.132%-8.633% of crude fat, and the balance of carbohydrate, crude fiber, ash and water. According to the artificial compound feed disclosed by the invention, the collagen deposition of the schizothorax grahami is remarkably improved, and the artificial compound feed also has a certain promoting effect on the protein deposition of the schizothorax grahami.

The utility model relates to a kind of nanostructure of laser surface treatment aggregate, wherein the surface of the aggregate is titanium metal, and at least one microchannel with titanium dioxide (TiO2) after cooling is formed by laser melting and sputtering to form molten titanium, at least one microchannel includes: at least one micropore, at least one guide channel, and at least one nano-wall formed at least one nano-bulge layer and at least one nano-wall. The following bone healing and antibacterial index effects and purposes are achieved: A. accelerate bone healing related protein deposition, B. accelerate bone cell attachment, C. induce neovascularization, D. accelerate early calcification and bone mineralization, E. improve nutrient exchange, F. stabilize surface bone structure, and G. resist plaque formation.

The present disclosure provides methods and an apparatus for imaging and analysing images of presumed protein deposits in the retina, retinal tissue or retinal structures and discloses methods differentiating or classifying these deposits and other optical signals from retinal structures into 1) whether they contain or do not contain classes, of proteins or protein deposits called amyloids or other proteins and / or protein deposits related to neurodegenerative eye and brain disease(s): 2) which type(s) of amyloid or other proteins or protein deposits they contain, as well as 3) whether the form and / or properties of the deposit are associated with a class of diseases or with one or another specific condition(s) (or disease(s)); whether or not this is a disease or class of disease associated with the retina or more generally with the nervous system, including the brain or 4) classified as associated with one or another level of severity of condition(s), or disease(s).

The invention discloses a stem cell-negative hydrogen ion compound preparation for treating Alzheimer's disease, and belongs to the technical field of biomedicine, the compound preparation comprises stem cells, a negative hydrogen ion donor, piceatannol glucoside and a pharmaceutically acceptable carrier. Wherein the concentration of the stem cells is 1 * 10 < 6 >-1 * 10 < 8 > / mL, the concentration of the negative hydrogen ion donor is 25-45mg / mL, and the concentration of piceatannol glucoside is 4-8mu g / mL. The composite preparation integrates neural restoration, anti-inflammatory and immunoregulation functions of stem cells, an efficient antioxidant protection effect of a negative hydrogen ion donor and synergistic interaction and safety guarantee effects of piceatannol glucoside. Animal experiments prove that the composite preparation can significantly improve cognitive impairment of Alzheimer's disease model rats and relieve neuroinflammation, oxidative stress and beta-amyloid protein deposition through synergistic anti-inflammatory, anti-oxidation and neuroprotection mechanisms.

The invention discloses an amaranthus hypochondriacus silage total mixed ration formula and a feeding method, and relates to the technical field of silage. Comprising the following raw materials: modified amaranthus hypochondriacus silage stalks, amaranthus hypochondriacus silage leaves, corn silage, alfalfa hay, corn, modified cottonseed meal, soybean meal, wheat bran, a buffering agent, a functional agent, modified attapulgite, a cattle fattening premix, stone powder and table salt. According to the beef cattle feed disclosed by the invention, the added modified grain amaranth silage stalks can reduce the digestion barrier of beef cattle to coarse feed, guarantee the utilization efficiency of daily ration fibers, and avoid the influence on the feed intake and the weight gain effect of the beef cattle due to too high proportion of low-digestion fibers; the added modified cottonseed meal provides crude protein with high utilization rate for beef cattle, and ensures the protein deposition and growth performance of the beef cattle in the fattening period; the added functional agent can inhibit the reproduction of harmful flora, improve the digestion and utilization rate of the whole feed, and guarantee the stability and high efficiency of rumen fermentation.

The invention discloses a silicon hydrogel material as well as a preparation method and application thereof. The preparation method comprises the following steps: curing and molding 2-hydroxyethyl methacrylate (HEMA), 3-(trimethylsiloxy) propyl methacrylate (TRIS), ethylene glycol dimethacrylate (EGDMA), a silane coupling agent and a photoinitiator through a photopolymerization reaction to obtain a silicon hydrogel substrate; performing oxygen plasma treatment; preparing a PDMS hydrophobic layer; performing oxygen plasma treatment; soaking in an organic solution containing a hydrophobic initiator; and forming a hydrophilic polymer layer. The high oxygen permeability, long-acting moisture retention, low friction and protein deposition resistance of the lens are realized by constructing a'hydrophobic water locking-hydrophilic lubrication 'double-layer functional interface.

The invention discloses a method for dynamically predicting the daily ration crude protein demand amount in the fattening stage of Ningxiang pigs, and particularly relates to the technical field of daily ration crude protein demand amount prediction. Comprising the following steps: S1, fitting a growth curve of Ningxiang pigs in a fattening stage; s2, predicting the protein deposition efficiency of the Ningxiang pigs in the fattening stage; and S3, establishing a Ningxiang pig daily ration crude protein intake prediction model based on a factorial method. The Ningxiang pig daily ration crude protein demand quantity dynamic prediction model is established based on the factorial method, and the daily ration crude protein demand quantity can be accurately predicted according to the actual production levels of different farms, so that personalized feed formula preparation is guided. The method can predict the daily ration crude protein demand amount of different Ningxiang pig farms, provides an important technical basis for precise breeding, improves the comprehensive benefits of the farms, and reduces the environmental pollution.

The invention belongs to the technical field of biomedicine and biology, particularly relates to a medicine capable of treating diseases related to protein sedimentation, and particularly discloses a medicine for treating or improving diseases or symptoms related to protein sedimentation, the medicine contains Emc3 protein, and the amino acid sequence of the Emc3 protein is shown as SEQ ID No: 1; the nucleotide sequence of the Emc3 protein is as shown in SEQ ID No: 2. The Emc3 can be used as a target gene for screening and preparing drugs for improving cardiac protein sedimentation, cardiac myocardial cell hypertrophy, cardiac hypertrophy, cardiac failure and the like, reducing death caused by protein deposition and prolonging survival time.

The invention discloses a novel therapy for improving the pathological process of Parkinson's disease by using a microbial preparation (Bacteroides maculatus). The application proves that the application of the bacteroides maculatus (B.coprocola) can relieve Parkinson-related motor deficit, alpha-synuclein protein deposition, dopaminergic neuron apoptosis and intestinal flora imbalance, effectively improves the pathological process of Parkinson, and can be used for treating Parkinson's disease, and the application of the bacteroides maculatus (B.coprocola) can be used for treating Parkinson's disease. The composition can maintain the ecological stability of intestinal microorganisms, improve the athletic ability of Parkinson's patients and reduce systemic chronic inflammatory response of Parkinson's patients, and can be used for preventing and / or treating Parkinson's disease.

The invention discloses a feed for promoting piglet growth and protein deposition, and belongs to the technical field of animal nutrition. The feed is a complete formula feed with the standard ileum digestible protein level of 13.2%-16.4%, and contains 0.1%-1.0% of a composite functional additive. The additive is composed of 10%-30% of coated sodium butyrate, 5%-15% of a lactobacillus probiotic preparation, 3%-10% of yeast beta-glucan, 2%-8% of a nucleotide mixture, 8%-20% of glutamine, 1%-5% of acid protease and a carrier. Through the synergistic effect of the additive and the low-protein daily ration, the intestinal health, nutrient substance digestion and absorption and immune states of piglets are comprehensively improved, so that the technical effects of improving the feed efficiency, promoting body protein deposition and reducing the diarrhea rate are achieved while the protein level of the daily ration is reduced and the cost is saved.

The invention provides a hyaluronic acid contact lens nano-composite coating and a preparation method thereof, and belongs to the technical field of contact lenses. The composite coating is a contact lens coating based on hyaluronic acid and a nano composite material, through a covalent cross-linking and physical adsorption dual mechanism, hyaluronic acid provides a continuous hydration effect to prevent lens drying, hyaluronic acid and nano cellulose synergistically lock water, and long-acting moisturizing is realized; the PDA nano-particles are recombined after being wetted, the hydrophilicity is recovered, and the wettability is improved; the nano composite layer forms a physical barrier, tear protein adsorption is reduced, and the protein deposition resisting effect is improved; the coating has self-repairing capability, can recover hydrophilicity after blinking or wetting by eye drops, and has repeatable wettability. The composite coating provided by the invention is suitable for soft contact lenses for daily polishing, moon polishing and the like.

A contact lens and a method of manufacturing the same are provided. The contact lens includes a contact lens body and a blue light blocking material covering the contact lens body. The blue light blocking material includes a plurality of metal particles dispersed on the contact lens body. The present invention includes compositions of at least one compound including metal ion with at least one or more reducing factors. The interactions between reducing factors endow contact lens body with homogeneous or pupil-regional preference of metal particles distribution with enhanced or decreased efficacy of blue light blocking. A further modification strengthens surface properties of contact lens including contact angle, water break-up time and long-term protein depositions.

The invention provides a penaeus vannamei protein deposition accelerant and penaeus vannamei feed, and belongs to the technical field of feed additives, the penaeus vannamei protein deposition accelerant provided by the invention comprises a small peptide composition with the molecular weight of 150-1500Da, and the small peptide composition is formed by compounding a marine protein enzymolysis product and a plant protein enzymolysis product. The feed provided by the invention can effectively improve the food calling property of the penaeus vannamei boone, increase the digestible energy of the feed, improve the intestinal morphology of the penaeus vannamei boone, improve the protein utilization rate of the penaeus vannamei boone and effectively increase the yield of the penaeus vannamei boone.

The invention belongs to the technical field of care solutions, and provides an anti-proteolysis contact lens care solution based on a nanotechnology. The protein deposition resistant contact lens care solution based on the nanotechnology is prepared from sulphobetaine, nano-liposome, hyaluronic acid, a complexing agent, an antibacterial agent, a pH regulator, an osmotic pressure regulator and water. The mass percent of each raw material is limited. The nano lipidosome with a core-shell structure is introduced, and the nutritional component is the core material, so that the nano lipidosome has the effects of resisting oxidation and relieving fatigue; the shell material is nano-liposome modified by alkyl glycoside and has excellent hydrophilicity; the nano-liposome, the sulphobetaine and the hyaluronic acid have a synergistic effect, so that the deposition of protein is destroyed; the complexing agent and metal ions form a complex, so that the metal ions are prevented from participating in protein deposition, and protein deposition is further prevented and reduced; the nanotechnology is successfully applied to moisturizing / lubricating components, protein deposition can be synergistically prevented, and the comfort of long-time wearing is improved.

The invention relates to an A beta-PET brain template construction and quantitative analysis method based on deep learning, and the method comprises the steps: obtaining a PET image preprocessed by a normal participant, namely, an A beta-PET image; performing spatial registration to MNI152, and performing intensity normalization processing, data screening and average calculation to obtain a preliminary A beta-PET brain template image; the screened A beta-PET image is registered to a preliminary A beta-PET brain template image, and a final A beta-PET brain template image is obtained through intensity normalization processing, data screening, average calculation and smoothing processing; calculating a first quantitative parameter to construct a brain amyloid protein deposition data database; and performing spatial registration on the A beta-PET image to be analyzed to the final A beta-PET brain template image, dividing a brain region, calculating a second quantitative parameter, and comparing the second quantitative parameter with the brain amyloid protein deposition data database to complete quantitative analysis. The method has the beneficial effects that a normal A beta-PET brain template data database is established, a matched quantitative amyloid protein deposition analysis process is provided for clinical use, and the registration effect and the diagnosis and treatment efficiency are improved.

The invention belongs to the technical field of biological medicines, and discloses a composite targeted drug for targeted alleviation of Alzheimer's disease, in a single preparation, the active components comprise 5-10 mg of TAU protein precursor and 5-20 mg of lithium orotate, and a medicinal carrier is supplemented to prepare the composite targeted drug for targeted alleviation of Alzheimer's disease. The medicinal carrier comprises a targeted delivery material TAU protein precursor, and one or more of a filler, a disintegrating agent and an adhesive. According to the medicine, by means of the blood-brain barrier penetrating capacity and targeting of TAU protein precursors and in combination with the neuron metabolism regulation effect of lithium orotate, multi-mechanism synergistic treatment is achieved, targeting and bioavailability are improved, beta-amyloid protein deposition and nerve fiber tangling can be effectively reduced, the neuron function is improved, the treatment effect is excellent, and safety is good.

The disclosure relates to a system comprising software that predicts responsiveness of healthy subjects or subjects at risk for or suffering from Alzheimer's Disease to certain disease modifying drugs. Embodiments of the disclosure include methods comprising analyzing images of the brain for depositions of amyloid-beta (Aβ) protein and tau protein, and correlating protein deposition levels to drug responsiveness.

The present disclosure provides methods and an apparatus for imaging and analysing images of presumed protein deposits in the retina, retinal tissue or retinal structures and discloses methods differentiating or classifying these deposits and other optical signals from retinal structures into 1) whether they contain or do not contain classes, of proteins or protein deposits called amyloids or other proteins and / or protein deposits related to neurodegenerative eye and brain disease(s); 2) which type(s) of amyloid or other proteins or protein deposits they contain, as well as 3) whether the form and / or properties of the deposit are associated with a class of diseases or with one or another specific condition(s) (or disease(s)); whether or not this is a disease or class of disease associated with the retina or more generally with the nervous system, including the brain or 4) classified as associated with one or another level of severity of condition(s), or disease(s).

The invention discloses a pig growth prediction method based on all-organism computing power and biochemical antagonism correction, which comprises the following steps: acquiring pig growth related data and carrying out data preprocessing to obtain a standard data set; according to the standard data set, effective net energy is calculated by adopting a host-microorganism double-track system model; according to the effective net energy, dynamically adjusting the bio-availability of the nutrients through a biochemical antagonism correction mechanism to obtain corrected nutrient data; according to the corrected nutrient data, enforced fat energy distribution logic and multi-factor limitation arbitration are executed, and the final protein deposition amount and fat deposition amount are determined; according to the final protein deposition amount and fat deposition amount, pig growth performance parameters are predicted, and a pig growth prediction result is obtained. According to the method, digital twinborn simulation and high-precision prediction of the growth performance of the pigs in a complex nutrition environment and under an atypical feeding condition are realized.

The application discloses application of BAY 11-7085 in preventing and treating pneumonia. In the application, it is found through actual administration test of a model mouse that BAY 11-7085 can significantly reduce expression of inflammatory factors and protein content in alveolar lavage fluid, reduce a lung pathology score, thereby treating pneumonia, and effectively relieving or inhibiting alveolar protein deposition, pulmonary edema and death caused by pneumonia.

The application discloses a superparamagnetic nanomedicine targeting an Alzheimer's disease A beta protein pathological area and a preparation method and application thereof, and a structure of the superparamagnetic nanomedicine targeting the Alzheimer's disease A beta protein pathological area is Fe3O4-HS-PEG 600 -CO-NH2 complex polypeptide; the complex polypeptide is composed of a targeting A beta protein locating sequence, a transmembrane sequence, a Sema3A inhibiting peptide and a nerve protection peptide in sequence from N to C; the targeting A beta protein locating sequence is FFXXK. The application can effectively reduce hippocampal A beta protein deposition plaques by reducing the introduction of the Sema3A inhibiting peptide and the nerve protection peptide in the Alzheimer's disease A beta protein deposition pathological area, is beneficial to the repair of hippocampal nerve networks, and has great potential for treating Alzheimer's disease.

A soft gel material having anti-PCO properties and the use thereof. Provided is a "soft gel-type IOL material" that has injectability, suitability for minimally invasive surgery, a stepless zooming capability and biological resistance. A precursor of the material can be injected into an intraocular capsular bag by means of a syringe, resulting in an extremely small implantation incision, and then undergoes in-situ cross-linking into a soft gel in the intraocular capsular bag, mimicking the performance of a natural crystalline lens in young people, thereby enabling cataract patients to regain natural accommodation function after surgery. The implanted soft gel has properties such as anti-cell adhesion and anti-protein deposition, which prevent the occurrence of PCO. Compared with existing IOL products, the implanted soft gel has a longer service life while providing patients with better visual quality.

A contact lens and a method of manufacturing the same are provided. The contact lens includes a contact lens body and a blue light blocking material covering the contact lens body. The blue light blocking material includes a plurality of metal particles dispersed on the contact lens body. The present invention includes compositions of at least one compound including metal ion with at least one or more reducing factors. The interactions between reducing factors endow contact lens body with homogeneous or pupil-regional preference of metal particles distribution with enhanced or decreased efficacy of blue light blocking. A further modification strengthens surface properties of contact lens including contact angle, water break-up time and long-term protein depositions.

This invention discloses a bicyclic compound, its intermediate, a preparation method, and its applications. Specifically, it discloses a compound as shown in Formula I, and its pharmaceutically acceptable salt or isotope. The compound of this invention exhibits good binding ability to amyloid protein, a short half-life, and good imaging effect. Furthermore, the compound of this invention can be used to prepare positron emission tomography (PET) agents and can be used for the early diagnosis of amyloid protein deposition-related diseases, such as Alzheimer's disease, and for monitoring the efficacy of drugs.

The invention provides a coating process of a hyaluronic acid contact lens with a bionic tear layer, and belongs to the technical field of contact lenses. The preparation method comprises the following steps: mixing a siloxane monomer and a photoinitiator to obtain a siloxane premixed solution; adding hyaluronic acid into glyceryl methacrylate for esterification reaction to obtain modified hyaluronic acid; the preparation method comprises the following steps: dissolving a silicone hydrogel monomer, a siloxane premixed solution and a cross-linking agent in a solvent to obtain an intermediate solution, immersing a contact lens substrate into the intermediate solution, and then sequentially adding polyvinylpyrrolidone and 2-methacryloyloxyethyl phosphorylcholine for cross-linking curing to obtain a prepolymer; and immersing the prepolymer into modified hyaluronic acid, carrying out surface grafting through plasma treatment, and then adding a photoinitiator for post-curing treatment, thereby obtaining the product. According to the coating process, through the synergistic effect of all the components, the biocompatibility with the substrate is improved, the protein deposition resistance is improved while the oxygen permeation amount is kept, and the moisturizing effect is prolonged.

The invention discloses an application of mesenchymal stem cell extracellular vesicles in preparation of a medicine for treating diseases caused by beta amyloid protein deposition, and provides a new application of the mesenchymal stem cell extracellular vesicles used for SD rat bone marrow in preparation of a medicine for treating A beta 25-35 infection. The toxicity caused by A beta 25-35 in pc12 cells is reduced by reasonably utilizing extracellular vesicles of SD rat bone marrow mesenchymal stem cells. Therefore, the toxicity of the PC12 is inhibited, and the PC12 is protected from deeper invasion. A new thought is provided for treatment of the Alzheimer's disease.

The invention discloses a synergistic improvement effect of rectum peptide combined with penta-hydroxydiphenylketone on renal fibrosis, and belongs to the technical field of biological medicines. Research results show that the Proctolin and the Macurin reduce extracellular matrix synthesis by inhibiting mRNA expression of fibrosis-related genes (Col1a1, Acta2 and Col3a1) and Col3a1 protein deposition, so that the renal fibrosis is relieved, the Proctolin and the Macurin show a remarkable renal fibrosis inhibiting effect in a TGF-beta induced cell model and a UUO animal model, and the combined use effect of the Proctolin and the Macurin is more remarkable. In conclusion, Proctolin and Macurin can effectively improve renal fibrosis of mice, results of in-vitro cell experiments are consistent with results of in-vivo animal models, the effect of mixed medication is better, and an experimental basis is provided for development of anti-fibrosis compound medicines.

The invention discloses a method for predicting net energy requirements of piglets with different weaning weights, and belongs to the field of animal nutrition and feed science. According to the method, a factorial method is adopted, and the net energy demand amount of piglets is divided into a maintenance net energy demand amount, a protein deposition net energy demand amount and a fat deposition net energy demand amount. The method comprises the following steps: collecting data such as piglet body components, body weight, feed intake and the like, establishing a relation model of body weight, body protein and body fat deposition rate of 5-25kg piglets, determining energy contents of body protein and body fat, establishing a relation model of net energy demand, body weight, protein and fat deposition energy, and distinguishing model differences of piglets with high and low weaning weight. And dynamically predicting the net energy demand amount and the optimal feed net energy concentration in combination with the growth curve and the feed intake curve. According to the method, the feed utilization efficiency is improved, the cost is reduced, and a basis is provided for accurate feeding.

The application discloses a kind of based on KH-550 modified composite phase change hemostatic material and its preparation method and application;The composite phase change hemostatic material is made of sodium-based montmorillonite nanoparticles, KH-550, 1,6-hexanediol;Among them, KH-550, 1,6-hexanediol is grafted on the surface of sodium-based montmorillonite nanoparticles by hydrogen bond and covalent bond;KH-550 modified sodium-based montmorillonite provides adsorption and coagulation platform, 1,6-hexanediol is used to adjust the hydrogen bond network, forming property and phase change property of composite system, and further introduce polyphenol functional components to enhance the tissue adhesion and protein deposition capacity of the material;The material has the advantages of rapid hemostasis, good wound adhesion, strong dosage form adaptability, good biocompatibility, antibacterial and anti-inflammatory and promoting wound healing, etc., can be prepared into hemostatic powder, hemostatic sponge, hemostatic film, hemostatic gel or hemostatic dressing, and is suitable for surface and internal wound hemostasis.