Preparation method of night cold-treating soft capsules

A technology of soft capsules and gelatin, which is applied in capsule delivery, medical preparations containing active ingredients, and pharmaceutical formulas, etc. It can solve the problems of complex preparation process and poor product stability, and achieve simple process, beautiful appearance and high stability. Effect

Active Publication Date: 2013-12-25
安士制药(中山)有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The existing preparation process is complicated, and the stability of the prepared product is relatively poor

Method used

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  • Preparation method of night cold-treating soft capsules
  • Preparation method of night cold-treating soft capsules
  • Preparation method of night cold-treating soft capsules

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] The soft capsule of the present invention comprises a soft capsule rubber and a content wrapped in the soft capsule rubber, and the content comprises the following components by weight percentage:

[0030]

[0031] Wherein said soft capsule rubber consists of the following components by weight percentage:

[0032] Gelatin 50%

[0033] Plasticizer 45%

[0034] Purified water 5%.

[0035] Wherein said polyethylene glycol is polyethylene glycol 400; said polyhydric alcohol is one or both of propylene glycol and glycerin. The povidone is povidone K12; the plasticizer is glycerin.

[0036] Soft capsule of the present invention can be prepared by following process:

[0037] 1. Preparation of gelatin solution:

[0038] Dissolve the plasticizer in water, add it to the plastic tank and heat it to 40°C, add gelatin, stir to dissolve above 60°C, and set aside;

[0039] 2. Preparation of contents:

[0040] Mix polyethylene glycol, polyol. Add povidone into the above mixt...

Embodiment 2

[0044] The soft capsule of the present invention comprises a soft capsule rubber and a content wrapped in the soft capsule rubber, and the content comprises the following components by weight percentage:

[0045]

[0046]

[0047] Wherein said soft capsule rubber consists of the following components by weight percentage:

[0048] Gelatin 90%

[0049] Plasticizer 5%

[0050] Purified water 5%.

[0051] Wherein said polyethylene glycol is the mixture of polyethylene glycol 200 and polyethylene glycol 400. Described polyhydric alcohol is the mixture of propylene glycol, glycerin. The povidone is a mixture of povidone K12, povidone K17 and povidone K25. The plasticizer is a mixture of glycerin, sorbitol, part of sorbitan, maltitol, mannitol, propylene glycol, polyethylene glycol 200, and polyethylene glycol 400.

[0052] Soft capsule of the present invention can be prepared by following process:

[0053] 1. Preparation of gelatin solution:

[0054] Dissolve the plasti...

Embodiment 3

[0060] The soft capsule of the present invention comprises a soft capsule rubber and a content wrapped in the soft capsule rubber, and the content comprises the following components by weight percentage:

[0061]

[0062] Wherein said soft capsule rubber consists of the following components by weight percentage:

[0063]

[0064] Wherein said polyethylene glycol is the mixture of polyethylene glycol 200, polyethylene glycol 400 and polyethylene glycol 600. Described polyhydric alcohol is propylene glycol. The povidone is a mixture of povidone K12, povidone K17, povidone K25, povidone K29 / 32 and povidone K30. Described plasticizer is maltitol. Described colorant is D&C Yellow No.10.

[0065] Soft capsule of the present invention can be prepared by following process:

[0066] 1. Preparation of gelatin solution:

[0067] Dissolve the plasticizer in water, add it to the glue tank and heat it to 70°C, add gelatin, stir and dissolve above 80°C. Add the coloring agent into ...

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PUM

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Abstract

The invention discloses a preparation method of night cold-treating soft capsules. The preparation method comprises the steps: A, preparing a gelatin liquid: dissolving a plasticizer in water, adding into a gelatin-melting tank and heating, adding gelatin into the gelatin-melting tank, stirring to dissolve, adding a colorant into water, stirring evenly to obtain a pigment solution, adding the pigment solution into the gelatin solution, mixing and vacuumizing to discharge air bubbles, and thereby obtaining the gelatin liquid; B, preparing contents: mixing polyethylene glycol and a polyol to obtain a mixed liquid, adding povidone into the mixed liquid, stirring to dissolve, adding acetaminophen, stirring into a mixed suspension, then adding the mixed suspension into a liquid mixing tank, vacuumizing and introducing inert gas, heating to dissolve, after acetaminophen is dissolved, cooling, adding dextromethorphan hydrobromide and doxylamine succinate, vacuumizing, carrying out heat preservation for dissolving, and thereby obtaining a content solution; and C, preparing the soft capsules: respectively adding the gelatin solution and the content drug solution into a pelleting press, pelleting, drying, wiping pills, and packaging. The invention aims to provide the preparation method of the night cold-treating soft capsules, wherein the preparation method has the advantages of simple process, convenient production and good product stability.

Description

technical field [0001] The invention relates to a preparation method of a night-use soft capsule for treating colds. Background technique [0002] As a common respiratory disease, colds are mainly characterized by headache, fever, cough, nasal congestion, runny nose, and allergies. Medications commonly used to treat these symptoms include: the antipyretic and pain reliever acetaminophen, the cough suppressant dextromethorphan hydrobromide, and the antihistamine doxylamine succinate. [0003] Due to the different properties and stability of these drugs, it is a challenge to produce compound preparation products containing the above drugs and make the drugs in them stable and effective. The existing preparation process is complex, and the prepared product has poor stability. Therefore, the existing technology for making the night-use soft capsules for treating colds containing these medicines needs to be further improved. Contents of the invention [0004] The purpose of ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/485A61K9/48A61P11/00A61P29/00A61P25/04A61P11/02A61P11/14A61P37/08A61K31/167A61K31/4402
Inventor 符联昌贾卫东
Owner 安士制药(中山)有限公司
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