Check patentability & draft patents in minutes with Patsnap Eureka AI!

Preparation method of polyethylene glycol-polyester triblock copolymer drug-loaded nanomicelle

A technology of polyethylene glycol and drug-loaded nanometers, which is applied in the field of polymers, can solve problems such as the limitation of preparation methods of drug-loaded micelles, and achieve the effects of improving encapsulation efficiency and solubility, simple operation, and stable structure

Active Publication Date: 2016-09-28
CHANGCHUN INST OF APPLIED CHEMISTRY - CHINESE ACAD OF SCI
View PDF2 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Therefore, the preparation method of drug-loaded micelles is also subject to certain limitations.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Preparation method of polyethylene glycol-polyester triblock copolymer drug-loaded nanomicelle
  • Preparation method of polyethylene glycol-polyester triblock copolymer drug-loaded nanomicelle
  • Preparation method of polyethylene glycol-polyester triblock copolymer drug-loaded nanomicelle

Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0032] The embodiment of the present invention discloses a preparation method of a polyethylene glycol-polyester triblock copolymer drug-loaded nanomicelle, comprising the following steps:

[0033] (A) drop the mixture of small molecule drug and organic solvent into polyethylene glycol-polyester triblock copolymer to obtain a mixed solution;

[0034] (B) adding ultrapure water dropwise while stirring the mixed solution for the first time, after continuing the second stirring, dialysis to remove the organic solvent and freeze-drying to obtain drug-loaded nanomicelles;

[0035] The polyethylene glycol-polyester triblock copolymer is shown in formula (I),

[0036]

[0037] where -R- is or

[0038] m is the degree of polymerization, 10≤m≤250, preferably 40≤m≤200, more preferably 60≤m≤150; n is the degree of polymerization, 10≤n≤220, preferably 30≤n≤20, more preferably 60≤n≤150.

[0039] In the present invention, the nano-sedimentation method is used to prepare the polyet...

Embodiment 1～6

[0052] Preparation of polyethylene glycol-poly(D-lactide) triblock copolymers initiated by polyethylene glycol with different number average molecular weights

[0053] Weigh polyethylene glycol (PEG) 1.67g, 6.67g, 13.33g, 16.67g, 33.33g, 66.57g with molecular weights of 1000, 4000, 8000, 10000, 20000, and 40000, respectively, and put them into the reaction flask, and azeotropically remove them. Water, add 12 g of D-lactide (DLA) in an anhydrous and oxygen-free environment, ventilate, the volume (mL) of toluene is 10 times the weight (g) of the ester monomer, 120 mL, the volume of stannous octoate and The molar ratio of the ester monomer was 1 / 1000, and 1 mL of 0.1 mol / L stannous octoate toluene solution was injected with a syringe, and then put into an oil bath at 120°C for reaction for 24 hours. After the reaction is completed, the solution is cooled, and 1200 mL of diethyl ether is used to settle while stirring. The amount ratio of diethyl ether and toluene is 10 / 1. The Buch...

Embodiment 7～10

[0059] Preparation of polyethylene glycol-poly(D-lactide) triblock copolymers with different degrees of polymerization initiated by polyethylene glycol

[0060] Weigh 4g, 6g, 8g, 12g of polyethylene glycol (PEG) with a molecular weight of 4000 and put them in a reaction flask, remove water azeotropically, and add 12g of D-lactide (DLA) in an anhydrous and oxygen-free environment. Ventilation, the volume (mL) of toluene is 10 times the weight (g) of the ester monomer, 120mL, the volume of stannous octoate and the molar ratio of the ester monomer are 1 / 1000, and 0.1mol / L octanoic acid is injected with a syringe 1 mL of stannous solution in toluene was put into an oil bath at 120 °C for 24 h. After the reaction is completed, the solution is cooled, and 1200 mL of diethyl ether is used to settle while stirring. The amount ratio of diethyl ether and toluene is 10 / 1. The Buchner funnel is filtered, and the obtained product is dissolved in chloroform, and then settled with diethyl et...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
encapsulation rateaaaaaaaaaa
Login to View More

Abstract

The invention provides a preparation method of polyethylene glycol-polyester tri-block copolymer drug-loaded nano-micelle: adding dropwise a mixture of small molecule drug and organic solvent to polyethylene glycol-polyester tri-block copolymerization In the mixture, a mixed solution was obtained; the mixed solution was stirred for the first time and ultrapure water was added dropwise, after the second stirring was continued, the organic solvent was removed by dialysis and freeze-dried to obtain drug-loaded nano micelles. The method prepares polyethylene glycol-polyester triblock copolymer drug-loaded nanomicelles, the operation is simple, the conditions are mild, and the generated nanomicelle particles can present a good monodisperse state, and the nanomicelles prepared by the method The inner core can encapsulate small molecule drugs with poor water solubility, and greatly improve the encapsulation efficiency and solubility of the drug. The obtained polyethylene glycol-polyester triblock copolymer drug-loaded nano-micelle has a stable structure, small particle size, and easy save.

Description

technical field [0001] The invention relates to the field of macromolecules, in particular to a method for preparing a polyethylene glycol-polyester triblock copolymer drug-loaded nanomicelle. Background technique [0002] The polymer carrier drug is an emerging drug delivery technology with the development of pharmaceutical research, biomaterial science and clinical medicine. Low-molecular-weight drugs have the advantages of high efficacy and convenient use, but they also have great side effects. Usually, low-molecular-weight drugs enter the human body through oral administration or injection, with fast metabolism, short half-life and lack of selectivity. The polymer carrier drug refers to the polymer that has no pharmacological effect and does not react with the drug as the carrier of the drug. It is formed by weak hydrogen bonding with the drug, or the low-molecular drug is connected to the polymer host through a polycondensation reaction. A class of drugs obtained from...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/51A61K47/34B82Y5/00B82Y40/00
Inventor 丁建勋刘东红陈学思庄秀丽
Owner CHANGCHUN INST OF APPLIED CHEMISTRY - CHINESE ACAD OF SCI
Features
  • R&D
  • Intellectual Property
  • Life Sciences
  • Materials
  • Tech Scout
Why Patsnap Eureka
  • Unparalleled Data Quality
  • Higher Quality Content
  • 60% Fewer Hallucinations
Social media
Patsnap Eureka Blog
Learn More

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2025 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com