Bacterial cellulose composite dressing

A technology of bacterial cellulose and composite materials, applied in fiber processing, biochemical fiber processing, biochemical equipment and methods, etc., can solve problems such as performance degradation, and achieve the effects of improving mechanical strength, prolonging service time, and improving antibacterial performance.

Active Publication Date: 2014-01-01
钟春燕
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

These methods can prepare bacterial cellulose composite materials, but the three-dimensional nano-network structure of bacterial cellulose itself is often destroyed during the preparation process, resulting in the degradation of some properties of the composite material due to the destruction of the bacterial cellulose structure, such as: mechanical properties Strength, water absorption performance, air permeability, etc.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] Acetobacter xylinum, a microorganism of the genus Acetobacter that can secrete bacterial cellulose, was activated to prepare seed mash, and then the seed mash with a strain concentration of 10% was evenly added dropwise on sterile polyester sterile On the surface of spun or woven cloth, add a small amount of fermentation medium after 5 minutes, so that the amount of fermentation medium added is controlled at a distance of 5 mm from the surface of the medium to the bottom of the culture container. The fermentation temperature is 25 °C and the time is 48 hours. The membrane material of bacterial cellulose and non-woven fabric or woven fabric is initially compounded. Add fermentation medium to the preliminary composite membrane material, where the amount of fermentation medium added is controlled at a distance of 20 mm from the liquid surface of the medium to the bottom of the culture container, the fermentation temperature is 30 ° C, and the non-woven or woven fabric is tu...

Embodiment 2

[0029] The Rhizobia microbial strains capable of secreting bacterial cellulose were activated to prepare seed mash, and then the seed mash with a strain concentration of 15% was evenly added dropwise on the sterile nylon non-woven fabric after autoclaving. On the surface of cloth or woven cloth, add a small amount of fermentation medium after 6 minutes, so that the amount of fermentation medium added is controlled at a distance of 8 mm from the medium liquid level to the bottom of the culture container, the fermentation temperature is 28 °C, and the time is 40 hours. The membrane material of bacterial cellulose and non-woven fabric or woven fabric is initially compounded. Add fermentation medium to the preliminary composite membrane material, so that the amount of fermentation medium added is controlled at a distance of 25mm from the liquid surface of the medium to the bottom of the culture container, the fermentation temperature is 32°C, and the non-woven or woven fabric is tu...

Embodiment 3

[0032] The sarcinina genus microbial strains capable of secreting bacterial cellulose were activated to prepare seed mash, and then the seed mash with a strain concentration of 35% was evenly added dropwise on the sterile viscose treated by autoclaving On the surface of fiber non-woven fabric or woven fabric, add a small amount of fermentation medium after 7 minutes, so that the amount of fermentation medium added is controlled at a distance of 10 mm from the medium liquid surface to the bottom of the culture container, the fermentation temperature is 30 ° C, and the time is 32 hours. The membrane material of bacterial cellulose and non-woven fabric or woven fabric is initially compounded. Add fermentation medium to the preliminary composite membrane material, so that the amount of fermentation medium added is controlled at a distance of 30 mm from the liquid surface of the medium to the bottom of the culture container, the fermentation temperature is 34 ° C, and the non-woven or...

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PUM

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Abstract

The invention relates to a bacterial cellulose composite dressing, which is prepared by soaking a composite material composed of bacterial cellulose and non-woven fabrics or woven fabrics in an antibiotics-containing water solution. The bacterial cellulose composite dressing is prepared by following steps: choosing bacterial strains capable of secreting bacterial cellulose to made into a seed mash, then evenly dropwise adding the seed mash on non-woven fabrics or woven fabrics, which have been subjected to a sterilization treatment, adding a small amount of fermentation culture medium for cultivation of 12 to 48 hours, then adding fermentation culture medium, cultivating for 3 to 6d, taking out the fermentation products, and finally subjecting the fermentation products to a purifying treatment so as to obtain the bacterial cellulose composite non-woven fabrics or woven fabrics. The preparation method has the advantages of simple technology, and convenient operation, and is capable of preparing bacterial cellulose wound dressings with various functions according to the needs.

Description

technical field [0001] The invention relates to the technical field of medical equipment and its preparation, in particular to a bacterial cellulose composite dressing. Background technique [0002] Bacterial cellulose is a polymer compound composed of glucose linked by β-1,4-glycosidic chains. As an excellent biological material, it has its unique physical and chemical properties: BC has a natural three-dimensional nano-network structure; Tensile strength and elastic modulus; high hydrophilicity, good air permeability, water absorption, water permeability, extraordinary water holding capacity and high wet strength. In addition, a large number of studies have shown that bacterial cellulose has good in vivo and in vitro biocompatibility and good biodegradability, which makes bacterial cellulose itself applicable to the field of biomedicine. The use of simple bacterial cellulose as a dressing has been reported abroad, and it has been industrialized for clinical use. Therefor...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L15/28A61L15/44D06M15/05D06M16/00C12P19/04C12R1/02C12R1/41C12R1/01C12R1/38C12R1/025C12R1/05C12R1/065
Inventor 钟春燕
Owner 钟春燕
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