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Method for determining content of panax pseudoginseng in musk ointment for promoting blood circulation by removing blood stasis

A technology for promoting blood circulation and removing blood stasis and content, applied in measurement devices, instruments, scientific instruments, etc., can solve the problems of inability to extract and difficult to extract, and achieve the effects of simple operation, strong specificity and high accuracy

Inactive Publication Date: 2015-06-03
CHONGQING UNISPLENDOUR CHEM
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, because the rubber ointment is different from other preparations, it contains a large amount of rubber matrix, which is composed of rubber, zinc oxide, rosin, lanolin, vaseline, liquid paraffin and other substances, and it is difficult to extract it by the above methods
A large number of experiments have proved that none of the above extraction methods can extract the Rg contained in Panax notoginseng 1 , Rb 1 and R 1 effectively extracted

Method used

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  • Method for determining content of panax pseudoginseng in musk ointment for promoting blood circulation by removing blood stasis
  • Method for determining content of panax pseudoginseng in musk ointment for promoting blood circulation by removing blood stasis
  • Method for determining content of panax pseudoginseng in musk ointment for promoting blood circulation by removing blood stasis

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0047] A method for assaying the content of Panax notoginseng in musk promoting blood circulation and removing blood stasis ointment, which is specifically determined according to the following steps:

[0048] The preparation of the test solution takes a size of 7 × 10cm 2 / 10 pieces of musk promoting blood circulation and removing blood stasis ointment (batch number 20130701) per piece, remove the cover lining, accurately weigh, the mass is 23.4603g, cut into pieces, mix evenly, accurately weigh 7.0381g equivalent to the weight of three pieces, and separate the liquid Add 50ml of ether to the funnel, soak for 10 minutes, shake fully to dissolve the ointment, accurately add 50ml of water, shake fully, let it stand, separate the water, wash with ether twice, 15ml each time, discard the ether, water The solution is filtered with dry filter paper, and the filtrate is taken to obtain the final product;

[0049] Preparation of reference substance solution Accurately weigh ginseno...

Embodiment 2

[0076] The size is 7×10cm 2 / Each tablet of musk promoting blood circulation and removing blood stasis ointment (batch number: 20130801) is several pieces, remove the cover lining, accurately weigh, cut into pieces, mix evenly, accurately weigh 6.1616g, which is equivalent to 3 pieces, and prepare according to Example 1 for supply Test solution and reference solution, inertsil ODS-SP (5μm, 250×4.6mm) for the chromatographic column, and other chromatographic conditions are the same as in Example 1, and are measured and calculated according to the method described in Example 1. Measured Rg in the test solution 1 , Rb 1 and R 1 The peak areas are respectively: 479.1, 200.6, 84.5; Rg in the control solution 1 , Rb 1 and R 1 The peak areas are still respectively: 514.2, 178.4, 122.6.

[0077] Calculated: the content of Panax notoginseng in each tablet of Musk Huoxue Huayu Ointment (in Rg 1 , Rb 1 and R 1 The total amount) is: 2.42mg.

Embodiment 3

[0079] Get musk promoting blood circulation and removing blood stasis ointment (lot number: 20130802), accurately weigh the quality that is equivalent to 3 pieces and be 6.2865g, operate and calculate by embodiment 1 step, record Rg in the need testing solution 1 , Rb 1 and R 1 The peak areas are respectively: 332.5, 144.4, 55.9; Rg in the control solution 1 , Rb 1 and R 1 The peak areas are still respectively: 514.2, 178.4, 122.6.

[0080] Calculation: the content of Panax notoginseng in each tablet of Musk Huoxue Huayu Ointment (in Rg 1 , Rb 1 and R 1 The total amount) is: 1.69mg.

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Abstract

The invention relates to a method for determining the content of panax pseudoginseng in musk ointment for promoting blood circulation by removing blood stasis. The method comprises the steps of dissolving ointment with diethyl ether firstly, then adding water for dissolving, extracting Rg1, Rb1 and R1, standing, separating liquid, washing water liquid with the diethyl ether, filtering with dry filter paper and determining the filtrate by using a high performance liquid chromatography. The determination method has relatively high accuracy and precision degree, easiness and convenience for operation, strong specificity and durability and can be used for quality control of the musk ointment for promoting the blood circulation by removing the blood stasis.

Description

technical field [0001] The invention relates to the determination of the content of notoginseng in the musk promoting blood circulation and removing blood stasis ointment, in particular to a method for determining the content of notoginseng in the musk promoting blood circulation and removing blood stasis ointment. Background technique [0002] Musk Huoxue Huayu Ointment is a compound rubber ointment preparation combining Chinese and Western medicine. It has obvious functions of promoting blood circulation and removing blood stasis, reducing inflammation and relieving pain. It is mainly used for the treatment of joint sprains, soft tissue contusions, acute lumbar sprains, lumbar muscle strain, and frozen shoulder. And diseases such as frostbite and erythema nodosum. The rubber plaster preparation contains eleven medicines, of which the notoginseng medicinal material accounts for more than 45%. Panax notoginseng is a plant of the genus Ginseng of Araliaceae, which has the ef...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N30/02
Inventor 罗延谷胡欣李文艳罗财勇何咏梅朱丽利
Owner CHONGQING UNISPLENDOUR CHEM
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