38results about How to "Applicable quality control" patented technology

This invention relates to compound thrombus-relaxing agent fingerprint spectrum recreation method by use of natural plants medicinal materials, which comprises the following parts: test solution process; comparing liquid process; measuring with effective liquid chromatograph measurement with chromatograph relative keeping time and peak area as one; computing the test items relative keeping time and relative peak area to get the HPLC fingerprint chromatograph. The required HPLC standard fingerprint chromatograph to notoginseng chromatograph has five common peaks; the one to astragalus root has two common peaks; chromatograph to radix salvia miltiorrhiza has two common peaks; one to scrophularia root has two common peaks; the one to radix salvia miltiorrhiza under 270 nm has three common peaks; the one to scrophularia root has common peak.

The invention discloses a HPLC-ELSD content determination method for paeoniflorin and albiflori in red paeony roots. The method includes the steps that 1, a test product solution is prepared; 2, comparison product solutions are prepared; 3, detection is performed, namely, the paeoniflorin comparison product solution and the albiflori comparison product solution in the step2 are taken to be detected under the detection conditions of C18 columns, isocratic elution is performed with an acetonitrile-0.05% formic acid aqueous solution as a mobile phase, HPLC-ELSD detection is performed through an ELSD detector, and curves are drawn to obtain standard curve equations; HPLC-ELSD detection is performed on the test product solution in the step1 under the conditions through the ELSD detector, obtained peak areas of the paeoniflorin and the albiflori are substituted into the standard curve linear regression equations, and then the contents of the paeoniflorin and the albiflori in the red paeony roots can be obtained. The method is good in specificity, durability, precision and accuracy and suitable for global quality control over the Chinese herb-red paeony roots.

The invention discloses an impurity detection method of cefozopran hydrochloride. Chromatographic conditions are as follows: an ACE Excel CN-ES chromatographic column and a Waters Atlants T3C18 chromatographic column are connected in series; methanol and acetonitrile in a volume ratio of (20-30): (70-80) are taken as a mobile phase A, and a triethylamine aqueous solution with a mass concentration of 0.3-0.5% is taken as a mobile phase B; and the volume ratio of the mobile phase A to the mobile phase B is (20-40): (60-80). By adopting the method provided by the invention, the separation degree of each peak of the cefozopran hydrochloride bulk drug is good, the separation degree is greater than 1.5, and the tailing factor is 0.8-1.2. The method is also suitable for detection of various damaged samples with more impurities, and is more beneficial to quality monitoring of cefozopran hydrochloride.

The invention relates to a method for high sensitivity detection of oversulfated chondroitin sulfate and dermatan sulfate in heparin sodium. A gradient elution method is used for elution, a CIM-QA monolithic column with the diameter of 12mm and height of 3mm is used, ultrapure water is used as a mobile phase A, a high-purity water mixed solution is used as a mobile phase B, and the mixed solution comprises lithium phosphate, dimethyl formamide, glycol and high purity water. The method has the characteristics of low equipment investment, low detection cost and simple processes, has high detection sensitivity, short detection time and good reappearance, can be used for tracking detection of oversulfated chondroitin sulfate and dermatan sulfate and is suitable for quality control in large scale production.

The invention provides an automatic controlling method, comprising the following steps: S0, inputting a target parameter of objects to be processed; S1, sequentially transmitting the objects to be processed to form a transmission queue; S2, when an object to be processed enters the processing position, measuring the actual parameter of the object as a current object to be processed at the processing position; S3, judging whether the actual parameter of the current object to be processed complies to the target parameter or not, if so, continuously executing step S1, otherwise, executing step S4; and S4, taking out the current object to be processed, and continuously executing step S1. By adopting the solution, defective objects or rejects can be automatically taken out by comparing and judging with the target parameter, so that a product line can be upgraded by automatic control, and manpower resources are saved; and the method is particularly suitable for quality control of electronic products such as mobile phones, tablet computers and televisions, and is also suitable for quality control of mechanical products.

The invention provides a high-performance liquid chromatography determination method for determining the content of 10-HDA in the royal jelly soft capsule. The shell of the soft capsule is destroyed by alkaline hydrolysis, adjusted to pH ≤ 5.0 with an acidity regulator (phosphoric acid, hydrochloric acid, sulfuric acid, formic acid, acetic acid), and extracted with absolute ethanol on an ultrasonic wave. The method adopted in the invention can effectively measure the content of 10-HDA in the royal jelly soft capsule, and the method has high accuracy, high sensitivity and good reproducibility.

This invention relates to compound thrombus-relaxing agent fingerprint spectrum recreation method by use of natural plants medicinal materials, which comprises the following parts: test solution process; comparing liquid process; measuring with effective liquid chromatograph measurement with chromatograph relative keeping time and peak area as one; computing the test items relative keeping time and relative peak area to get the HPLC fingerprint chromatograph. The required HPLC standard fingerprint chromatograph to notoginseng chromatograph has five common peaks; the one to astragalus root hastwo common peaks; chromatograph to radix salvia miltiorrhiza has two common peaks; one to scrophularia root has two common peaks; the one to radix salvia miltiorrhiza under 270 nm has three common peaks; the one to scrophularia root has common peak.

The invention discloses a method for detecting the fingerprint of anti-lung cancer sea mulberry recipe, comprising the following steps: step 1: preparation of a reference peak solution; step 2: preparation of a test solution of anti-lung cancer ha mu recipe; step 3: separately precise Inject the quantitative reference peak solution and the test solution into the liquid chromatograph, and record the chromatogram; Step 4: Export the Haimu Fang fingerprint instrument obtained in step 3, and import it into the Chinese medicine chromatographic fingerprint similarity evaluation system, select different The chromatographic peaks that exist in the chromatograms of the batches of Haimufang tested are regarded as common peaks, and the average value calculation method is used to generate the control fingerprint of Haimufang, and the relative retention time and relative peak area of ​​each common peak are calculated. The fingerprint spectrum of the Haimu prescription provided by the invention can comprehensively and objectively characterize the quality of the Haimu prescription, and is beneficial to comprehensively monitor the quality of the medicine. The fingerprint detection method provided by the invention has the advantages of simple method, stability, high precision, good reproducibility and the like.

The invention belongs to the field of medicinal material detection, and in particular relates to a quality detection method for Yupingfeng particles. The quality detection of the Yupingfeng particlescomprises character detection, thin-layer chromatography detection, fingerprint spectrum detection and content limitation detection. The quality detection method for the Yupingfeng particles providedby the invention can authenticate two traditional Chinese medicines: Astragalus membranaceus and Radix saposhnikoviae at a time via a method by using thin-layer chromatography, and is high in accuracyand strong in practicability; the fingerprint spectrum and component content of the Yupingfeng particles can be measured in a unified manner by using ultra-high performance liquid chromatography; viatechnological investigation, the content measurement method provided by the invention is high in accuracy, good in stability and excellent in repeatability, significantly reduces analysis and detection time, and has great significance in setting of Yupingfeng particle quality standard.

The invention discloses a round pipe roundness correction device which comprises a support, a swing rod, a round pipe correction assembly and a balance assembly, the round pipe correction assembly is located at the feeding end of a take-up machine and can conduct roundness correction on a round pipe to be wound, and meanwhile the balance assembly can balance the acting force of the wound round pipe on the take-up machine on the swing rod. The circular pipe guided out of the circular pipe correction assembly is always tangent to a reel of the take-up machine, and the circular pipe subjected to roundness correction is effectively prevented from bending and deforming again. The device has roundness correction and anti-bending functions, solves the problems that the roundness of the round aluminum pipe becomes poor and the dimensional precision is reduced due to multi-pass bending deformation in the vertical direction after the round aluminum pipe is extruded and before the round aluminum pipe is wound, is beneficial to realizing continuous extrusion winding displacement of the high-precision round pipe, and is suitable for quality control of the refrigeration round aluminum pipe. The circular tube continuous extrusion take-up and winding displacement system comprises circular tube forming equipment, a take-up machine and the circular tube roundness correction device.

The invention discloses an ion chromatography method for simultaneously detecting mepiquat as a main component and N-methylpiperidine as an impurity in a pesticide. The ion chromatography method comprises the following steps of (1) setting the temperature of a column oven to be 45 DEG C; (2) setting the sample injection amount to be 25 microliters; (3) setting applied suppression current to be 15mA; (4) preparing leacheate; (5) preparing a standard solution; (6) analyzing a mixed standard solution with the N-methylpiperidine and the mepiquat; (7) diluting a liquid sample by 10,000 times as a sample solution for later use; (8) filtering a post-treated sample through a disposable needle type filter, putting the sample into an ion chromatography for analysis to measure the contents of negative N-methylpiperidine and mepiquat ions. The method disclosed by the invention is quick, simple and accurate, is suitable for quality control in pesticide production and can meet a requirement on technical control in a pesticide production process.

The present invention relates to a detection method of nourishing serum and brain preparation, said method is high-performance liquid chromatography, comprising the following steps: step 1, preparation of test solution, step 2, preparation of reference solution, step 3, chromatography Condition; Step 4, assay, need testing solution and reference substance solution are injected high-performance liquid chromatograph, obtain chromatogram. In the method provided by the present invention, after the test sample is processed by a solid-phase chromatographic column, the components are analyzed after enrichment and purification, so that the analysis time of the corresponding chromatographic method is shorter, and at the same time, the separation of chromatographic peaks and the weight of the method are guaranteed. and the present invention clearly defines the relative quantitative mode of the fingerprint, and clearly defines the control requirements of the absolute quantitative index (2) of the content determination and the relative quantitative index (19) of the fingerprint, and the control index is more comprehensive, to The quality attributes of the product are described more quantitatively.

The invention relates to a method for determining the content of panax pseudoginseng in musk ointment for promoting blood circulation by removing blood stasis. The method comprises the steps of dissolving ointment with diethyl ether firstly, then adding water for dissolving, extracting Rg1, Rb1 and R1, standing, separating liquid, washing water liquid with the diethyl ether, filtering with dry filter paper and determining the filtrate by using a high performance liquid chromatography. The determination method has relatively high accuracy and precision degree, easiness and convenience for operation, strong specificity and durability and can be used for quality control of the musk ointment for promoting the blood circulation by removing the blood stasis.

The invention discloses a method for determining the content of harpagoside in a radix scrophulariae medicinal material, which belongs to the technical field of content determination methods, and comprises the following steps: preparing a standard solution, detecting by adopting an ultrahigh pressure liquid chromatography-tandem single quadrupole mass spectrometry detector, recording a mass spectrum, determining the peak intensity of main ions and adduct ions, calculating the ratio of the intensity, and determining the content of harpagoside in the radix scrophulariae medicinal material according to the content of harpagoside in the radix scrophulariae medicinal material. Drawing a standard curve of the ratio and the content; under the same condition, the test solution is detected, the content of harpagoside in the medicinal material is obtained according to the standard curve, and the method mainly adopts a quantitative method in which the ratio of the ion strength of the components on a single quadrupole mass spectrometry detector replaces a numerical detection signal of an instrument.

The invention discloses a method for measuring and evaluating the emulsifying property of a surfactant, which comprises the steps of (1) uniformly mixing simulated crude oil and a surfactant solution;(2) measuring a multi-light scattering spectrum; (3) determining an evaluation reference time point T0, the corresponding peak width L0 and the corresponding average light intensity [delta]BS0; (4) calculating the oil phase volume Vo1 and the emulsified oil rate [alpha]o; (5) calculating the peak area width L and the relative average light intensity [delta]BS; (6) determining the derivative relation shown in the description of the dimensionless peak width relative to the dimensionless time, and solving the mean shown in the description of derivatives at different time points; (7) determiningthe derivative of the dimensionless back scattering average light intensity relative to the dimensionless time, and solving the mean shown in the description of derivatives at different time points; and (8) calculating a comprehensive index [eta] to serves as an index for comprehensively evaluating the emulsifying property. The method of the invention comprehensively takes the emulsified oil amount, the emulsion aggregation ability and the coalescence ability into consideration, and has guiding significance for the measurement, evaluation and screening of the surfactant for chemical flooding in the oilfield.

The invention provides a method for measuring the content of 4,4'-bi(hydroxymethyl) biphenyl (4,4'-BHMBP). In the method, a capillary gas-phase chromatographic column is used for separating the 4,4'-bi(hydroxymethyl) biphenyl, and an automatic sample injector is used for quantifying the 4,4'-bi(hydroxymethyl) biphenyl by adopting an external standard calibration curve method. The method is characterized in that a fixed phase of the capillary gas-phase chromatographic column is 5 percent phenyl 95 percent polydimethylsiloxane, the length of the column is 15-60m, the inner diameter of the column is 0.2-0.5mm, the film thickness of the inner diameter of the column is 0.1-0.6mum, the initial temperature of the column is 60-150 DEG C, and the heating rate is 4-10 DEG C / min; and the sample size of the automatic sample injector is 0.2-5mul, the split ratio is (5:1)-(50:1), and the vaporization temperature is 230-270 DEG C. The method is simple, quick and accurate, is a more ideal qualitative and quantitative analysis method for measuring the content of the 4,4'-BHMBP and is suitable for the quality monitoring of 4,4'-BHMBP products.