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Application of sargassum fusiforme sulphated polysaccharide in preparation of anti-aging drugs and healthcare products

A vegetable sulfuric acid and anti-aging technology, which is applied in the application field of hijiki sulfate polysaccharide in the preparation of anti-aging medicines and health products, can solve the problem that the anti-aging effect of hijiki sulfate polysaccharide cannot be confirmed, and the anti-aging activity has not been reported. problems, to achieve the effect of prolonging life and broad application prospects

Inactive Publication Date: 2014-01-29
SHANGHAI OCEAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

It can be seen from the above theories that aging is a very complicated process. Therefore, even though the prior art has disclosed that hijiki sulfated polysaccharides have the antioxidant activity of scavenging free radicals, it cannot be confirmed that hijiki sulfated polysaccharides have anti-aging properties. effect, especially the effect of prolonging lifespan, but there is no report on the anti-aging activity of hijiki sulfated polysaccharides

Method used

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  • Application of sargassum fusiforme sulphated polysaccharide in preparation of anti-aging drugs and healthcare products

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] Example 1 Extraction of hijiki sulfated polysaccharide

[0019] Take the water extraction method to extract the sulfated polysaccharides of hijiki, the specific method is as follows:

[0020] (1) Extraction of crude polysaccharides from hijiki

[0021] Raw materials of hijiki were stirred and leached in 80% ethanol solution for 24 hours, and leached twice to remove pigment, etc., to obtain ethanol extract and algae residue respectively. Extract the residue with hot water, mix it at a ratio of 1:10, adjust the pH to 4 with 0.1% HCl solution, extract it in a water bath at 30°C for 3 hours, and filter the extracted solution with 200-mesh gauze , and then vacuum concentrated and vacuum freeze-dried for 24 hours to obtain the residue water extract, which is the crude polysaccharide of hijiki.

[0022] (2) Extraction of hijiki sulfated polysaccharide

[0023] Concentrate the water extract of hijiki crude polysaccharide with a rotary evaporator, the conditions are: rotary ...

Embodiment 2

[0025] Example 2 Anti-aging test of hijiki sulfated polysaccharide

[0026] Drosophila lifespan experiments were used to study the anti-aging effect of seaweed active polysaccharides, and the anti-aging research and the application of more mature astragalus polysaccharides were used as controls to calculate the average lifespan (the arithmetic mean of the entire lifespan of each group of fruit flies) and the maximum lifespan (each group The arithmetic mean of the lifespan of the last 10 fruit flies that died) and the half-death time (the arithmetic mean of the lifespan of the first half of the fruit flies) were used as evaluation indicators.

[0027] 1 Experimental method

[0028] 1.1 Drosophila longevity experiment pre-treatment

[0029] ①Basic medium formula: See Table 1 for the components of the medium. The above components were dissolved in tap water, and the natural pH was maintained.

[0030] Table 1 Basal medium formula

[0031] name corn flour lactos...

Embodiment 3

[0046] Example 3 Anti-aging Drugs and Health Products Made from Hijiki Sulfate Polysaccharide

[0047] 1. Tablet

[0048] (1) The prescription of the preparation is as follows:

[0049]

[0050] (2) The preparation process is:

[0051] 1. Extraction: Extract the crude polysaccharide of Hijiki from Hijiki according to the extraction method described in Example 1, concentrate the obtained extract, and set aside;

[0052] ② Refining: the above-mentioned hijiki crude polysaccharide is concentrated to a certain concentration of thick paste, add an equivalent amount of 95% ethanol, mix well, let stand in refrigeration for more than 12 hours, filter, recover ethanol from the filtrate, and then continue to concentrate to thick paste ;

[0053] ③Granulation: Take 10g of the above-mentioned thick paste-like hijiki sulfate polysaccharide, add an appropriate amount of ethanol, starch and dextrin soft material, pass through a No. 1 sieve (12-14 mesh) to make granules;

[0054] ④ D...

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Abstract

The invention provides application of sargassum fusiforme sulphated polysaccharide in preparation of anti-aging drugs and healthcare products. The invention also provides the anti-aging drugs and the anti-aging healthcare products. The anti-aging drugs and the anti-aging healthcare products are prepared from the sargassum fusiforme sulphated polysaccharide and a pharmaceutical acceptable carrier. Tablets and oral liquid preparations of the anti-aging drugs and the anti-aging healthcare products are prepared. The sargassum fusiforme sulphated polysaccharide has the advantages that the effects of the sargassum fusiforme sulphated polysaccharide in aging resistance and increase of the service life are proved; a foundation is laid for development of the anti-aging drugs and the anti-aging healthcare products containing the sargassum fusiforme sulphated polysaccharide as an active component; the tablets and oral liquid preparations of the sargassum fusiforme sulphated polysaccharide are successfully developed.

Description

technical field [0001] The invention relates to a new application of hijiki sulfated polysaccharides, in particular to the application of hijiki sulfated polysaccharides in preparing anti-aging medicines and health care products. Background technique [0002] Anti-aging health food and drug research is a hotspot at present, and various anti-aging health care products are of great variety. Polysaccharides are widely distributed in nature and are important components of living matter. Studies have shown that polysaccharides can not only regulate the transmission and perception of information between immune cells, but also have multiple functions such as controlling cell differentiation and division, regulating cell growth and maintaining the normal metabolism of living organisms. Due to the special living environment of marine organisms, they often contain some structural polysaccharides. Studies have found that the polysaccharides of various marine organisms have various bio...

Claims

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Application Information

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IPC IPC(8): A61K31/737A61P39/06A23L1/29A23L33/00
Inventor 刘承初张朝燕张喆迩
Owner SHANGHAI OCEAN UNIV
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