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Magnetic resonance imaging detectable in-situ liquid crystal precursor embolism composition, preparation and application thereof

A magnetic resonance imaging, in-situ liquid crystal technology, applied in the fields of MRI/MRI contrast agent, X-ray contrast agent preparation, medical science, etc., can solve problems such as ectopic embolism, error, normal tissue damage, etc., to reduce Ionizing radiation damage, improving efficacy and safety, improving efficacy and safety

Active Publication Date: 2015-07-15
HYGEA MEDICAL TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the above embolic materials all have certain defects: that is, they cannot be directly detected by existing clinical detection methods.
Incomplete embolization will lead to persistence or recurrence of symptoms, and excessive injection of embolic agents may cause ectopic embolization, resulting in damage to normal tissues
However, the current clinical method of detecting the blood flow of the embolized vessel by DSA to judge the end point of embolism is not very accurate, and there will be certain errors.

Method used

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  • Magnetic resonance imaging detectable in-situ liquid crystal precursor embolism composition, preparation and application thereof
  • Magnetic resonance imaging detectable in-situ liquid crystal precursor embolism composition, preparation and application thereof
  • Magnetic resonance imaging detectable in-situ liquid crystal precursor embolism composition, preparation and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0076] Embodiment 1 contains the embolization composition of liquid crystal precursor of magnetic resonance imaging water-soluble contrast agent

[0077] ① Vortex and mix hot-melt 0.42g GMO and 0.28g absolute ethanol; ② Slowly add 0.10g water and 0.20g gadopentetate meglumine injection into ①, vortex and mix well, and centrifuge at 3000rpm for 20min The liquid crystal precursor embolic composition containing the magnetic resonance imaging water-soluble contrast agent is obtained.

Embodiment 2

[0078] Embodiment 2 contains the liquid crystal precursor embolic composition of magnetic resonance imaging non-water-soluble contrast agent

[0079] ①Mix 0.45g propylene glycol and 0.099g water evenly; ②Add 0.45g hot-melt phytantriol slowly to ①, vortex to mix evenly, and centrifuge at 4000rpm for 15min; ③Add 1mg of oleic acid-modified ferric oxide , sonication, and vortex mixing to obtain a liquid crystal precursor embolization composition containing a non-water-soluble contrast agent for magnetic resonance imaging.

Embodiment 3

[0080] Embodiment 3 contains the embolization composition of liquid crystal precursor of magnetic resonance imaging non-water-soluble contrast agent

[0081] Prescription 1: ① Vortex and mix hot-melt 0.42g GMO and 0.28g absolute ethanol; ② Slowly add 0.30g water to ①, vortex to mix, and centrifuge at 2000rpm for 25min.

[0082] Prescription 2: ① Vortex and mix hot-melt 0.42g GMO and 0.278g absolute ethanol; ② Slowly add 0.30g water to ①, vortex and mix evenly, and centrifuge at 2000rpm for 25min; ③ Add 2mg of oleic acid-modified Fe3iron tetroxide is added into ②, and ultrasonically and vortex mixed to obtain a liquid crystal precursor embolization composition containing a non-water-soluble contrast agent for magnetic resonance imaging.

[0083] Add 1 cm high agar solution to the petri dish, add 1 cm high distilled water after it cools and solidifies into agar gel, add the above prescriptions 1 and 2 to the water respectively, and the liquid crystal precursor composition turns ...

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Abstract

The invention discloses a magnetic resonance imaging detectable in-situ liquid crystal precursor embolism composition which comprises the following components: an MRI water-soluble or water-insoluble contrast medium, a liquid crystal material, a physiological acceptable water-soluble organic solvent and water. The following components can be added according to the treatment goal and the clinical demand: an X ray-impermeable water-soluble or water-insoluble contrast medium and / or drugs. The MRI detectable liquid embolism composition disclosed by the invention has the characteristics of low viscosity, no toxicity, low cost and fast curing, can be injected, and is mainly used in local embolism treatment and relevant imageological examination of tumors, vascular malformation and hemostasis.

Description

technical field [0001] The invention relates to an in-situ liquid crystal precursor embolic composition detectable by magnetic resonance imaging and applied in the field of medical interventional therapy, which is mainly used for embolization therapy of vascular malformation, hemangioma, liver cancer, kidney cancer, lung cancer and the like. Background technique [0002] Interventional therapy was developed in the 1970s. It is an interdisciplinary subject that combines medical imaging and clinical therapy. It has the characteristics of minimally invasive, fast recovery, and good curative effect. It has opened up new possibilities for previously incurable or intractable diseases. way of treatment. At present, it has become the three most important therapeutic disciplines along with internal medicine and surgery. Interventional embolization therapy is an important part of interventional therapy. With the guidance of imaging equipment, the doctor injects embolic material throu...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K49/06A61L31/14A61L31/18A61L31/00A61L31/16A61K49/04
Inventor 范田园杜玲然卢晓静柳盈盈
Owner HYGEA MEDICAL TECH CO LTD
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