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Applications of peptides compound in rhizome sparganii

A technology of compounds and peptides, applied in the field of medicine, can solve the problems of undiscovered active ingredients, stay, and restrictions on the promotion and application of triangular compounds, and achieve the effect of filling technical gaps and improving anticoagulant activity.

Active Publication Date: 2014-02-05
GUANGDONG PHARMA UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] However, the chemical composition of trigonium is complex, containing compounds such as flavonoids and flavonoid glycosides, phenylpropanoid glycosides, steroids and their glycosides, organic acids, although modern chemical and pharmacological studies have partially clarified the connection between chemical components and clinical applications , but there are still many active ingredients that have not been found, and many pharmacological studies only stay at the stage of extracts, which limits the further promotion and application of triangular compounds

Method used

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  • Applications of peptides compound in rhizome sparganii
  • Applications of peptides compound in rhizome sparganii
  • Applications of peptides compound in rhizome sparganii

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] Example 1 Extraction, separation, purification and structural identification of compounds represented by formula (I)

[0030] 1. Experimental materials:

[0031] (1) medicinal materials

[0032] Sanleng medicinal material was purchased from Guangzhou Zhixin Pharmaceutical Co., Ltd., batch number 090301, and was identified by Professor Li Shuyuan from the Department of Traditional Chinese Medicine Identification, School of Traditional Chinese Medicine, Guangdong University of Pharmacy Sparganium stoloniferum Buch.-Ham Dried tuber peeled off.

[0033] (2) Reagents and fillers

[0034] Chloroform (analytical grade, Tianjin Fuyu Fine Chemical Co., Ltd.);

[0035] Methanol (analytical pure, Tianjin Fuyu Fine Chemical Co., Ltd.);

[0036] Vanillin (Guangzhou Guanglianjin Chemical Factory);

[0037] Silica gel for column chromatography (80-100 mesh, 100-200 mesh, 200-300 mesh, Qingdao Ocean Chemical Factory);

[0038] Thin-layer chromatography silica gel (silica gel...

Embodiment 2

[0071] Example 2 Compound anticoagulant function test of the present invention

[0072] 1. Experimental materials

[0073] (1) Drugs

[0074] The compound obtained in Example 1: cyclic dipeptide A [cyclo-(phenylalanine-tyrosine)].

[0075] (2) Experimental animals

[0076] SD rats, weighing 180-250 g, were provided by the Experimental Animal Center of Guangzhou University of Traditional Chinese Medicine.

[0077] (3) Reagents

[0078] Heparin (sigma, batch number: 20120509);

[0079] Chloral hydrate (Guangzhou Sile Biochemical Reagent Co., Ltd.);

[0080] Prothrombin time PT kit (Nanjing Jiancheng Institute of Bioengineering, batch number: 20130314);

[0081] Activated partial thromboplastin time APTT kit (Nanjing Jiancheng Bioengineering Institute, batch number: 20130201);

[0082] Thrombin time TT kit (Nanjing Jiancheng Institute of Bioengineering, batch number: 20130314);

[0083] Normal saline (Guizhou Tiandi Pharmaceutical Co., Ltd., batch number A13011209);

...

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Abstract

The invention discloses applications of a peptides compound in rhizome sparganii in preparing anticoagulant and / or antithrombosis medicaments. The structural formula of the peptides compound is shown in the formula (I). The peptides compound obtained by separating and purifying rhizome sparganii, and applications thereof are provided for the first time, the compound plays a role in prolonging the prothrombin time (PT), activated partial thromboplastin time (APTT) and thrombin time (TT), has good anticoagulation activity, and provides a powerful basis for developing natural antithrombosis medicaments. The formula (I) is as shown in the specification.

Description

technical field [0001] The present invention relates to the technical field of medicine, and more specifically, relates to the application of a peptide compound in a triangular prism. Background technique [0002] Trigonum trigonum Sparganium stoloniferum The dried tuber of Buch.-Ham was first recorded in "Supplement to Materia Medica", and now it is recorded in "Chinese Pharmacopoeia". In addition to raw products and vinegar products used alone in traditional Chinese medicine, curcuma and astragalus are often used to enhance the curative effect. [0003] Modern pharmacological research shows that among the 35 commonly used drugs for promoting blood circulation and removing blood stasis, Sanleng ranks in the top 10 in terms of action strength, and is widely used in the treatment of cardiovascular and cerebrovascular diseases, tumors and various gynecological diseases. Especially for gynecological difficult diseases such as uterine fibroids and endometriosis, Sanleng has s...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/495A61P7/02C07D241/08
Inventor 梁生旺王淑美邓小慧陈舒茵刘贝胡旭光王佰灵
Owner GUANGDONG PHARMA UNIV
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