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Use of rice sprout extract in preparing medicament for treating fatty liver

A technology of fatty liver and water extract, which is applied in the field of medicine to achieve the effects of improving liver function and liver index, enriching existing technology and enriching drugs

Active Publication Date: 2015-07-08
启东苏星二氧化碳有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] All in all, there is currently no very effective drug for the treatment of fatty liver in clinical practice. Therefore, finding effective intervention drugs has very important theoretical significance and application value

Method used

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  • Use of rice sprout extract in preparing medicament for treating fatty liver
  • Use of rice sprout extract in preparing medicament for treating fatty liver
  • Use of rice sprout extract in preparing medicament for treating fatty liver

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0015] The preparation of embodiment 1 corn bud water extract

[0016] Dry 0.5kg of grain buds, add 8L of 75% ethanol, heat and reflux for extraction for 2 hours, filter, discard the filtrate, add 6L of 75% ethanol to the filter residue, heat and reflux for 1.5h, filter, discard the filtrate, add 6L of pure water to the filter residue Heat and reflux for extraction twice, 1 hour each time, combine the filtrates and concentrate to a paste, which is the extract. Freeze-drying and evacuating to obtain the freeze-dried powder of the grain bud extract.

Embodiment 2

[0017] The preparation of embodiment 2 Guya water extract

[0018] Dry 0.5kg of grain buds, add 6L of 85% ethanol, heat and reflux for extraction for 2 hours, filter, discard the filtrate, add 5L of 85% ethanol to the filter residue, heat and reflux for 1.5h, filter, discard the filtrate, add 6L of pure water to the filter residue Heat and reflux for extraction twice, 1 hour each time, combine the filtrates and concentrate to a paste, which is the extract. Freeze-drying and evacuating to obtain the freeze-dried powder of the grain bud extract.

Embodiment 3

[0019] Example 3 Effects of Guya Water Extract on Nonalcoholic Fatty Liver Model Rats

[0020] There were 36 SD rats, male, weighing 220±20g, 24 were randomly selected to make models by intragastric administration of high-fat emulsion combined with intraperitoneal injection of tetracycline, and the remaining 12 were raised normally. Intraperitoneal injection of tetracycline 150 mg / kg on the first day of modeling, and then intraperitoneal injection of tetracycline 110 mg / kg every 6 days, a total of 6 times; and high-fat emulsion was administered intragastrically at 9:30 every morning, with a dose of 10 ml kg -1 d -1 . High-fat emulsion formula: 20g lard, 10g cholesterol, 5g fructose, 5g sucrose, 1g bile salt, 1g sodium glutamate, 15ml propylene glycol, a little soil temperature 80, distilled water to 100ml. Gastrointestinal administration of high-fat milk continued for 8 weeks.

[0021] After one week of adaptive feeding, the successfully modeled rats were randomly divided i...

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Abstract

The invention discloses use of a rice sprout extract in preparing a medicament for treating fatty liver. Experimental researches find that the rice sprout extract is capable of remarkably improving liver functions and liver indexes of a patient suffering from fatty liver and reducing the activity of triglyceride to a certain degree; if the rice sprout extract is used together with a hypolipidemic drug, good curative effects for treating non-alcoholic fatty liver diseases can be achieved; thus the rice sprout extract has a popularization value.

Description

technical field [0001] The invention belongs to the technical field of medicines, and in particular relates to the use of grain bud extracts in the preparation of medicines for treating fatty liver. Background technique [0002] Fatty liver refers to the pathological changes caused by excessive accumulation of fat in liver cells due to various reasons. Fatty liver disease is a serious threat to the health of Chinese people, becoming the second largest liver disease after viral hepatitis, and has been recognized as a common cause of hidden cirrhosis. Fatty liver is a common clinical phenomenon rather than an independent disease. Its clinical manifestations are asymptomatic in mild cases, and violent in severe cases. Generally speaking, fatty liver is a reversible disease, early diagnosis and timely treatment can often return to normal. The total amount of fat in the liver of normal people accounts for about 5% of the liver weight, and contains phospholipids, triglycerides,...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/899A61P1/16A61K131/00
Inventor 范金云
Owner 启东苏星二氧化碳有限公司