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Wheat cellulose particles and preparation method thereof

A technology of wheat cellulose and hypromellose, which is applied in the field of medical care, can solve the problems of high dosage and low dietary fiber content, and achieve the effects of less consumption, promotion of proliferation, and intestinal laxation

Inactive Publication Date: 2014-02-19
JINAN HAILIJIAN BIOTECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the raw materials of health food with laxative function on the market are basically aloe vera, traditional Chinese medicine, dietary fiber, etc. Among them, dietary fiber is the main component, and the dosage of functional component insoluble dietary fiber varies from 0.98g to 17.44g. Laxative function, but there are disadvantages such as large dosage and low content of insoluble dietary fiber in the product
There is no product on the market that uses wheat cellulose as dietary fiber

Method used

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  • Wheat cellulose particles and preparation method thereof
  • Wheat cellulose particles and preparation method thereof
  • Wheat cellulose particles and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] Example 1: Preparation of Wheat Cellulose Granules

[0024] Prescription: 2730g of wheat cellulose, 270g of xylitol, 95% ethanol solution of 4% hypromellose in right amount.

[0025] Preparation method: Mix the wheat cellulose and xylitol in the prescribed amount evenly, use an appropriate amount of 4% hypromellose in 95% ethanol as a binder, wet granulate, dry below 80°C, granulate, pack, Instantly.

[0026] The process verification results are shown in Table 2:

[0027]

[0028] Three batches of product inspection results

[0029] Three batches of products were self-inspected, and the total number of microbiological index bacteria were 60, 50, and 60Cfu / g, coliforms <30MPN / 100g, mold and yeast <10Cfu / g, and other pathogenic bacteria were not detected. Efficacy The contents of insoluble dietary fiber in ingredients or iconic ingredients are 79.5g / 100g, 79.3g / 100g, and 79.1g / 100g respectively, and other physical and chemical indicators all meet the requirements o...

Embodiment 2

[0031] Example 2: Animal Safety Toxicology Test of Wheat Cellulose Granules

[0032] The present invention is subjected to acute toxicity test, Ames test, mouse bone marrow polychromatic erythrocyte micronucleus test, mouse sperm deformity test, and 30-day feeding test by Shandong University Health Analysis and Testing Center.

[0033] In the acute toxicity test, the MTD of the wheat cellulose granules of the present invention is greater than 18.0 g / kg.bw, and according to the acute toxicity classification, the wheat cellulose granules of the present invention are non-toxic.

[0034] In the genetic toxicity test, the results of Ames test, mouse bone marrow polychromatic erythrocyte micronucleus test and mouse sperm abnormality test were all negative.

[0035] In the 30-day feeding test, rats were fed with feeds prepared from wheat cellulose granules of the present invention that were 25 times, 50 times, and 100 times the daily recommended amount of the human body. For 30 conse...

Embodiment 3

[0037] Embodiment 3: Wheat cellulose granule laxative function animal experiment report

[0038] 1 Materials and methods

[0039] 1.1 Sample: The wheat cellulose granules of the present invention are provided by Jinan Hailijian Biotechnology Co., Ltd. Its properties are gray particles.

[0040] Experimental animals: Healthy SPF Kunming male mice provided by the Experimental Animal Center of Shandong University were selected, and the experimental animal production license number is SCXK (Lu) 20120004. The experimental environment temperature is 22°C±2°C, and the relative humidity is 50%±10%. The certificate number of the experimental animal environment facility is Ludonghuanzi No. H2002100112. Weight 18-22g. According to the weight level of the mice, they were randomly divided into 10 groups, with 12 mice in each group, 60 of which were subjected to the small intestine motility test, and the other 60 were subjected to the measurement experiment of the time of the fi...

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Abstract

The invention discloses wheat cellulose particles and a preparation method thereof. The prescription comprises 2730 g of wheat cellulose, 270 g of xylitol, and a proper amount of a 95% ethanol solution with 4% of hydroxypropyl methylcellulose. Each 100 g of the wheat cellulose particles contain more than 75.0 g of wheat cellulose particle insoluble dietary fibers; the wheat cellulose particles are administrated 2 times per day with 3 g per time, that is to say, 4.5 g of the insoluble dietary fibers are supplemented per day. Animal tests and human trial administration tests prove that the wheat cellulose particles have the laxative function, and have the total effective rate of 80.39%. The product is prepared by taking pure wheat cellulose as the raw material and adding a proper amount of xylitol, has high insoluble dietary fiber content compared with health foodstuff emerging in markets and having the laxative function, has less consumption amount, is convenient to administrate, and can bring a new health foodstuff new product which is convenient to administrate and has significant laxative function for extensive constipation patients.

Description

technical field [0001] The invention relates to the field of medical care, in particular to a wheat cellulose granule and a preparation method thereof. Background technique [0002] With the development of society and the improvement of living standards, people have higher and higher requirements for the quality of nutrients intake. The World Health Organization stipulates that each person should take 16g-24g of dietary fiber per day. From the perspective of my country's food structure, dietary fiber mainly comes from vegetables, with an average content of 3%, which is far from enough. Most healthy people defecate once a day, but it is normal to defecate once every other day or 2-3 days. If the stool stays in the intestinal cavity for too long, the water contained in it is excessively absorbed, so that the stool is too dry and hard, the normal frequency of defecation is disordered, the frequency of defecation is reduced, and the stool is incomprehensible for more than 48 to...

Claims

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Application Information

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IPC IPC(8): A23L1/09A23L29/30A23L33/24
CPCA23L33/21A23L29/30
Inventor 苑博
Owner JINAN HAILIJIAN BIOTECH
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