Wheat cellulose particles and preparation method thereof

A technology of wheat cellulose and hypromellose, which is applied in the field of medical care, can solve the problems of high dosage and low dietary fiber content, and achieve the effects of less consumption, promotion of proliferation, and intestinal laxation

Inactive Publication Date: 2014-02-19
JINAN HAILIJIAN BIOTECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the raw materials of health food with laxative function on the market are basically aloe vera, traditional Chinese medicine, dietary fiber, etc. Among them, dietary fiber is the main component, and the dosage of functional component insol

Method used

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  • Wheat cellulose particles and preparation method thereof
  • Wheat cellulose particles and preparation method thereof
  • Wheat cellulose particles and preparation method thereof

Examples

Experimental program
Comparison scheme
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Example Embodiment

[0023] Example 1: Preparation of wheat cellulose granules

[0024] Prescription: an appropriate amount of wheat cellulose 2730g, xylitol 270g, 4% hypromellose 95% ethanol solution.

[0025] Preparation method: mix the prescribed amount of wheat cellulose and xylitol uniformly, use 4% hypromellose 95% ethanol solution as a binder, wet granulation, dry below 80°C, sizing, packaging, Immediately.

[0026] The process verification results are shown in Table 2:

[0027]

[0028] Three batches of product inspection results

[0029] Three batches of products were self-inspected. The total number of microbial indicators were 60, 50, and 60Cfu / g, coliforms were less than 30MPN / 100g, molds and yeasts were both less than 10Cfu / g, and no other pathogenic bacteria were detected. The content of insoluble dietary fiber of ingredients or iconic ingredients is 79.5g / 100g, 79.3g / 100g, 79.1g / 100g, and other physical and chemical indicators meet the requirements of product quality standards.

[0030] The ...

Example Embodiment

[0031] Example 2: Animal safety toxicology test of wheat cellulose granules

[0032] The present invention has been subjected to acute toxicity test, Ames test, mouse bone marrow polychromatic erythrocyte micronucleus test, mouse sperm deformity test, and 30-day feeding test by the Health Analysis and Testing Center of Shandong University.

[0033] In the acute toxicity test, the MTD of the wheat cellulose granules of the present invention is greater than 18.0 g / kg.bw. According to the acute toxicity classification, the wheat cellulose granules of the present invention are non-toxic.

[0034] In the genetic toxicity test, the results of Ames test, mouse bone marrow polychromatic erythrocyte micronucleus test and mouse sperm abnormality test were all negative.

[0035] In the 30-day feeding test, rats were fed with 25 times, 50 times, and 100 times the recommended daily amount of the human body with the wheat cellulose pellets prepared feed of the present invention. For 30 consecutive ...

Example Embodiment

[0037] Example 3: Animal experiment report on the laxative function of wheat cellulose particles

[0038] 1 Materials and methods

[0039] 1.1 Sample: The wheat cellulose particles of the present invention are provided by Jinan Hailijian Biological Technology Co., Ltd. Its appearance is gray particles.

[0040] Experimental animals: The healthy SPF Kunming male mice provided by the Experimental Animal Center of Shandong University were selected, and the experimental animal production license number was SCXK (鲁)20120004. The experimental environment temperature is 22℃±2℃, and the relative humidity is 50%±10%. The certificate number of laboratory animal environmental facilities is Lu Donghuan H2002100112. Weight 18-22g. According to the weight of the mice, they were randomly divided into 10 groups with 12 mice in each group. Among them, 60 mice were tested for small intestine movement, and the other 60 mice were tested for the time to first black stool, the number of feces and ...

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Abstract

The invention discloses wheat cellulose particles and a preparation method thereof. The prescription comprises 2730 g of wheat cellulose, 270 g of xylitol, and a proper amount of a 95% ethanol solution with 4% of hydroxypropyl methylcellulose. Each 100 g of the wheat cellulose particles contain more than 75.0 g of wheat cellulose particle insoluble dietary fibers; the wheat cellulose particles are administrated 2 times per day with 3 g per time, that is to say, 4.5 g of the insoluble dietary fibers are supplemented per day. Animal tests and human trial administration tests prove that the wheat cellulose particles have the laxative function, and have the total effective rate of 80.39%. The product is prepared by taking pure wheat cellulose as the raw material and adding a proper amount of xylitol, has high insoluble dietary fiber content compared with health foodstuff emerging in markets and having the laxative function, has less consumption amount, is convenient to administrate, and can bring a new health foodstuff new product which is convenient to administrate and has significant laxative function for extensive constipation patients.

Description

technical field [0001] The invention relates to the field of medical care, in particular to a wheat cellulose granule and a preparation method thereof. Background technique [0002] With the development of society and the improvement of living standards, people have higher and higher requirements for the quality of nutrients intake. The World Health Organization stipulates that each person should take 16g-24g of dietary fiber per day. From the perspective of my country's food structure, dietary fiber mainly comes from vegetables, with an average content of 3%, which is far from enough. Most healthy people defecate once a day, but it is normal to defecate once every other day or 2-3 days. If the stool stays in the intestinal cavity for too long, the water contained in it is excessively absorbed, so that the stool is too dry and hard, the normal frequency of defecation is disordered, the frequency of defecation is reduced, and the stool is incomprehensible for more than 48 to...

Claims

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Application Information

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IPC IPC(8): A23L1/09A23L29/30A23L33/24
CPCA23L33/21A23L29/30
Inventor 苑博
Owner JINAN HAILIJIAN BIOTECH
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