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Probiotics fermented Xiaoshuan oral liquid and preparation method thereof

A technology of Xiaoshuan oral liquid and probiotics, which is applied in the field of medicine, can solve problems such as waste of medicinal materials, achieve the effects of improving taste, facilitating human body absorption, and enhancing curative effect

Active Publication Date: 2014-02-26
SANZHU FUER PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0014] The purpose of the present invention is to overcome the defect that the current Xiaoshuan oral liquid adopts alcohol precipitation process to remove polysaccharides, protein peptides and other macromolecular components in the prescription, resulting in waste of medicinal materials, and to provide a probiotic fermented Xiaoshuan oral liquid and its Preparation

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] Example 1: Preparation of Probiotic Fermented Xiaoshuan Oral Liquid

[0029] Weigh each Chinese medicine ingredient according to the following weight: Astragalus 600g Angelica 60g Radix Paeoniae Rubra 60g Dilong 30g Chuanxiong 30g Peach kernel 30g Safflower 30g, the above seven flavors, add water and decoct twice, the first time is 1.5 hours, the second time is 1.0 hours, combined decoction, filtered, and the filtrate was concentrated under reduced pressure to 50°C to measure the relative density of 1.02 to 1.08, adding 0.5% glucose by volume, 0.1% yeast powder by volume, and inorganic salts (FeSO 4 ·7H 2 O 1.0mg / 100ml, ZnSO 4 ·7H 2 O 4.4mg / 100ml,), 3.0% sucrose by volume, 0.01% sucralose by volume, adjust the pH to about 7.0 and sterilize at 115°C for 40 minutes, when the temperature drops to about 39°C, Inoculate the bacteria liquid of Bifidobacterium bifidum (isolated from normal human body and identified by the Institute of Microbiology, Chinese Academy of Scienc...

Embodiment 2

[0032] Example 2: Preparation of Probiotic Fermented Xiaoshuan Oral Liquid

[0033] Weigh each Chinese medicine ingredient according to the following weight: Astragalus 500g Angelica 50g Radix Paeoniae Rubra 50g Dilong 25g Chuanxiong 25g Peach Kernel 25g Safflower 25g, the above seven flavors, add water and decoct twice, the first time is 2.0 hours, the second time is 1.5 hours, combined decoction, filtered, and the filtrate was concentrated under reduced pressure until the relative density was measured at 50°C to be 1.02 to 1.07, adding 1.0% by volume of glucose, 0.2% by volume of yeast powder, inorganic salt (FeSO 4 ·7H 2 O 1.0mg / 100ml, ZnSO 4 ·7H 2 O 4.4mg / 100ml,), the volume percentage is 0.02% sucralose, adjust the pH to about 7.0 and sterilize at 121 °C for 30 minutes, when the temperature drops to about 39 °C, the volume percentage of inoculation preculture at the same time is 1.0% of Bifidobacterium breve (AS 1.2213) and about 0.3% by volume of Lactobacillus acidoph...

Embodiment 3

[0034] Example 3: Preparation of Probiotic Fermented Xiaoshuan Oral Liquid

[0035] Weigh each Chinese medicine ingredient according to the following weight: Astragalus 400g Angelica 40g Radix Paeoniae Rubra 40g Dilong 20g Chuanxiong 20g Peach Kernel 20g Safflower 20g, the above seven flavors, add water and decoct twice, the first time is 2.0 hours, the second time is 1.0 hours, combined decoction, filtered, and the filtrate was concentrated under reduced pressure to a relative density of 1.01 to 1.06 measured at 50°C, and an inorganic salt (FeSO 4 ·7H 2 O 1.0mg / 100ml, ZnSO 4 ·7H 2 O 4.4mg / 100ml,), the volume percentage is 0.01% sucralose, adjust the pH to about 7.0 and sterilize at 110°C for 60 minutes, when the temperature drops to about 39°C, the volume percentage of inoculated pre-culture is 1.0 % of Bifidobacterium breve (AS 1.2213) bacteria solution, cultured at 37°C for about 2 hours, then inoculated with about 0.5% volume percentage of Lactobacillus acidophilus (AS ...

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Abstract

The invention discloses a probiotics fermented Xiaoshuan oral liquid and a preparation method thereof. Bifidobacterium and lactobacillus beneficial to human bodies are used for fermenting water extractives of raw medicinal materials, namely astragalus membranaceus, angelica sinensis, root of common peony, lumbricus, ligusticum wallichii, peach kernel and red flower of the Xiaoshuan oral liquid. On the one hand, whole components of the water extractives of the traditional Chinese medicines are retained, and the medicinal materials are saved; on the other hand, after the water extractives are fermented by probiotics in intestinal tract, macromolecular substances are converted in vitro, so that the oral liquid is easy to absorb by human bodies, and the curative effect is improved; furthermore, in fermentation, abundant flavor substances are generated, so that the taste of the traditional Chinese medicine is improved. Experiments prove that the probiotics fermented Xiaoshuan oral liquid is superior to the Xiaoshuan oral liquid prepared by original technologies in shortening blood clotting time and improving mesentery microcirculation.

Description

technical field [0001] The invention relates to a probiotic fermented Xiaoshuan oral liquid for treating hemiplegia caused by apoplexy, crooked mouth and eyes, astringent speech, drooling at the corners of the mouth, fistula of lower limbs, and frequent urination, and a preparation method thereof, belonging to the technical field of medicine. Background technique [0002] The Xiaoshuan Oral Liquid prepared according to the preparation method given in the ministerial drug standard WS3-B-2241-96 has the functions of invigorating qi, promoting blood circulation and dredging collaterals. Oral preparations for stroke-induced hemiplegia, crooked mouth and eyes, awkward speech, salivation, fistula of lower limbs, and frequent urination. It has been clinically proven to be effective. It is a commonly used drug for clinical and family treatment of the above diseases. The following is the formula and process and brief description given in the WS3-B-2241-96 drug standard: [0003] P...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/736A61K9/08A61P7/02A61P9/10A61K35/56A61K35/62
Inventor 褚新红孙筱林吴炳新吕美甄宗武
Owner SANZHU FUER PHARMA
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