Temperature-sensitive chitosan-carboxymethylcellulose gel and preparation method thereof

A carboxymethyl cellulose, temperature-sensitive gel technology, applied in the field of chemical and biological materials, to achieve the effect of no toxic side effects, good natural degradability

Inactive Publication Date: 2014-02-26
ZHEJIANG UNIVERSITY OF SCIENCE AND TECHNOLOGY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the research on chitosan thermosensitive gel mainly includes the blend gel of chitosan and other polymers, such as chitosan-methylcellulose blend

Method used

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Examples

Experimental program
Comparison scheme
Effect test

example 1

[0014] Below 10°C, dissolve 100.2mg chitosan in 10ml HCl solution (0.1mol / L), adjust the pH to 4.6, and stir on a magnetic stirrer for 30min; dissolve 100.5mg sodium carboxymethylcellulose in 10ml In distilled water, stir to dissolve completely and set aside. Slowly add 8.5 ml sodium carboxymethyl cellulose solution into 10 ml chitosan solution dropwise, mix thoroughly, adjust the pH to 5.0, and centrifuge to remove air bubbles to obtain the chitosan-carboxymethyl cellulose gel system. Detected by the test tube inversion method, the mixed system formed a gel at 39°C for 7 minutes.

example 2

[0016] Weigh 109.0 mg of chitosan and dissolve it in 10 mL (0.1 mol / L) hydrochloric acid solution, adjust the pH to 4.6; weigh 97.0 mg of sodium carboxymethylcellulose and dissolve it in 10 mL of distilled water. Take 8ml of sodium carboxymethylcellulose solution and slowly add it dropwise into 10ml of chitosan solution, mix thoroughly, adjust the pH to 5.1, and centrifuge to remove air bubbles to obtain the chitosan-carboxymethylcellulose gel system. Detected by the test tube inversion method, the mixed system formed a gel at 39°C for 9 minutes.

[0017] The prepared chitosan-carboxymethylcellulose thermosensitive hydrogel is suitable for industries such as food, medicine and skin care products.

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PUM

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Abstract

The invention provides temperature-sensitive chitosan-carboxymethylcellulose gel and a preparation method and application thereof. The temperature-sensitive chitosan-carboxymethylcellulose gel is prepared by physically crosslinking the chitosan and sodium carboxymethylcellulose at the temperature of 10 DEG C or below. The gel system has rapid temperature-sensitive response performance and can be kept in a liquid state at room temperature or when the temperature is lower than room temperature, and gelatinization can be rapidly realized when the temperature reaches body temperature. The gel preparation method is simple and practicable in operation, the reaction conditions are mild, and organic chemical reagents or other harmful substances can be avoided. The prepared temperature-sensitive gel is suitable for industries such as medicine products, skin care products and foods.

Description

technical field [0001] The invention relates to a temperature-sensitive chitosan-carboxymethyl cellulose gel and a preparation method thereof, belonging to the field of chemical and biological materials. Background technique [0002] Thermosensitive gel refers to a mixed system that can undergo sol and gel changes as the temperature changes. Because of its unique temperature-sensitive properties, it can be used as a carrier material for drug sustained and controlled release systems, cell support, functional immobilized enzymes, etc. It can also be used for ophthalmic drug delivery, nasal cavity drug delivery, local injection drug delivery, etc. Used as a drug for tissue repair implants. [0003] Chitosan has been widely used in the research of gel materials because of its good hygroscopicity, adsorption, biocompatibility and degradability. At present, the research on chitosan thermosensitive gel mainly includes the blend gel of chitosan and other polymers, such as chitosan...

Claims

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Application Information

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IPC IPC(8): C08J3/075C08L5/08C08L1/28
Inventor 黄娟王建伟孙祎蔓
Owner ZHEJIANG UNIVERSITY OF SCIENCE AND TECHNOLOGY
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