Unlock instant, AI-driven research and patent intelligence for your innovation.

A kind of active adsorbent and its application in the production of glutamate dipeptide

A technology of active adsorbent and dipeptide, which is applied in the direction of peptides, other chemical processes, chemical instruments and methods, etc., can solve the problems of incomplete and effective removal of impurities and pigments, shorten the working hours of filtration, completely remove pigments, and improve product quality. quality effect

Active Publication Date: 2016-01-06
JING JING PHARMA
View PDF6 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

N(2)-L-alanyl-L-glutamine is adsorbed by activated carbon in the pre-treatment process, but activated carbon can only decolorize, remove impurities, and remove endotoxins, and cannot completely and effectively remove impurities and pigments and other substances

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] In this embodiment, the components of the active adsorbent are: white carbon black 45%, black carbon black 50%, ion exchange resin 2%, water 3%.

[0026] (1) Using alanine and glutamine as raw materials to synthesize glutamic acid dipeptide;

[0027] (2) In the sterile area, dissolve 10kg of dipeptide with 40kg of water for injection to obtain dipeptide feed liquid, add 0.10kg of active adsorbent to the feed liquid of dipeptide for adsorption for 40min, remove the adsorbent and pass through four-stage membrane filtration to sterilize; adsorption The humidity during the agent treatment process was 35%, and the temperature was 40°C;

[0028] (3) Pour the material after the adsorption treatment into the crystallization tank, and add methanol as a solvent for crystallization;

[0029] (4) Filtration, washing, drying and packaging.

Embodiment 2

[0031] In this embodiment, the components of the active adsorbent are: white carbon black 43%, black carbon black 55%, ion exchange resin 1.5%, water 0.5%.

[0032] (1) Using alanine and glutamine as raw materials to synthesize glutamic acid dipeptide;

[0033] (2) In the sterile area, dissolve 20kg of dipeptide with 30kg of water for injection to obtain a feed solution of dipeptide, add 0.5kg of active adsorbent to the feed liquid of dipeptide for adsorption for 25min, remove the adsorbent and sterilize through four-stage membrane filtration; adsorption The humidity during the agent treatment process was 40%, and the temperature was 60°C;

[0034] (3) Pour the material after the adsorption treatment into the crystallization tank, and add isopropanol as a solvent for crystallization;

[0035] (4) Filtration, washing, drying and packaging.

Embodiment 3

[0037] In this embodiment, the components of the active adsorbent are: white carbon black 38%, black carbon black 60%, ion exchange resin 0.5%, water 1.5%.

[0038] (1) Using alanine and glutamine as raw materials to synthesize glutamic acid dipeptide;

[0039] (2) In the sterile area, dissolve 15kg of dipeptide with 10kg of water for injection to obtain dipeptide feed liquid, add 0.5kg of active adsorbent to the feed liquid of dipeptide for adsorption for 30min, remove the adsorbent and pass through four-stage membrane filtration to sterilize; adsorption The humidity during the agent treatment process was 60%, and the temperature was 5°C;

[0040] (3) Pour the material after the adsorption treatment into the crystallization tank, and add ethanol as a solvent for crystallization;

[0041] (4) Filtration, washing, drying and packaging.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention discloses an active adsorbent and application thereof in an N(2)-L-alanyl-L-glutamine production process, belonging to the technical field of separation of compounds. The active adsorbent is prepared from the following raw materials in parts by weight: 30-45% of white carbon black, 50-65% of black carbon black, 0.5-3% of ion exchange resin and 0.5-3% of water. The application comprises the following steps: (1) synthesizing N(2)-L-alanyl-L-glutamine from alanine and glutamine; (2) dissolving the N(2)-L-alanyl-L-glutamine in water to obtain a N(2)-L-alanyl-L-glutamine solution, adding the active adsorbent into the N(2)-L-alanyl-L-glutamine solution to perform adsorption for 25-40 minutes, removing the adsorbent, and passing through a four-stage membrane to filter out bacteria; (3) pressurizing the solution subjected to adsorption treatment into a crystallization kettle, and adding a solvent to perform crystallization; and (4) filtering, washing, drying and subpackaging. The active adsorbent overcomes the defect that only the black carbon black is used for adsorption, can effectively remove bacteria, impurities and pigments, shorten the working hours for filtration, and greatly improves the product quality.

Description

technical field [0001] The present invention relates to the technical field of separation of compounds. Background technique [0002] Propane dipeptide (N(2)-L-alanyl-L-glutamine) is a white or off-white sterile powder, N(2)-L-alanyl-L-glutamine is an important intestinal Nutritional drugs. At present, N(2)-L-alanyl-L-glutamine is mainly used in injections, powder injections, water injections, and tablets. Because N(2)-L-alanyl-L-glutamine is unstable to light and heat, it is greatly restricted in the process of producing sterile raw materials. [0003] Chinese patent CN102698247A provides a method for crystallizing alanyl glutamine in the water phase. A high-concentration sterile filtrate is used to statically crystallize and precipitate a large number of crystals under low temperature conditions. After filtering and draining, the filter cake is dried under reduced pressure at 50°C for 4 hours. Available as a sterile powder. Chinese patent CN102491918 provides an aqueou...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Patents(China)
IPC IPC(8): B01J20/20C07K5/062C07K1/36C07K1/30
Inventor 李斌水徐浙龙张庆斌何连顺孔娟
Owner JING JING PHARMA