Stable compound omeprazole pharmaceutical composition
A technology of omeprazole sodium and its composition, which is applied in the field of freeze-dried injections containing omeprazole and domperidone, can solve the problems of high production cost, poor solubility, large consumption, etc., so as to reduce production cost and improve solubility , the effect of reducing the volume
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Embodiment 1
[0029] Freeze-dried powder injection prescription of omeprazole sodium and domperidone
[0030]
[0031]
[0032] Its preparation process: Weigh the prescribed amount of omeprazole sodium, domperidone, mannitol and histidine, dissolve them in 1600ml of water for injection, control the temperature at 30-50°C and stir to dissolve; add hydrochloric acid or hydrogen Sodium oxide solution, adjust the pH value to 10, then add 0.1% (W / V) activated carbon, keep warm for 20 minutes, decarbonize by coarse filtration, add water for injection to 2000ml, mix well, filter with 0.22μm microporous membrane, 100 Fill 1,000 bottles under a high-grade environment, half-stopper, freeze-dry in a freeze-drying box, cork out of the box, and cap.
Embodiment 2
[0034] Freeze-dried powder injection prescription of omeprazole sodium and domperidone
[0035]
[0036] Its preparation process: Weigh the prescribed amount of omeprazole sodium, domperidone, mannitol and histidine, dissolve them in 1600ml of water for injection, control the temperature at 30-50°C and stir to dissolve; add hydrochloric acid or hydrogen Sodium oxide solution, adjust the pH value to 11, then add 0.1% (W / V) activated carbon, keep warm for 20 minutes, decarbonize by coarse filtration, add water for injection to 2000ml, mix well, filter with 0.22μm microporous membrane, 100 Fill 1,000 bottles under a high-grade environment, half-stopper, freeze-dry in a freeze-drying box, cork out of the box, and cap.
Embodiment 3
[0038] Freeze-dried powder injection prescription of omeprazole sodium and domperidone
[0039]
[0040]Its preparation process: Weigh the prescribed amount of omeprazole sodium, domperidone, mannitol and histidine, dissolve them in 1600ml of water for injection, control the temperature at 30-50°C and stir to dissolve; add hydrochloric acid or hydrogen Sodium oxide solution, adjust the pH value to 10.5, then add 0.1% (W / V) activated carbon, keep warm for 20 minutes, coarsely filter and decarbonize, add water for injection to 2000ml, mix well, filter with 0.22μm microporous membrane, 100 Fill 1,000 bottles under a high-grade environment, half-stopper, freeze-dry in a freeze-drying box, cork out of the box, and cap.
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