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Preparation method of porous calcium polyphosphate biological material

A technology of calcium polyphosphate and biomaterials, applied in the field of biomedical materials, can solve the problems of material pollution, failure to obtain ideal material properties, and purity not reaching medical grade, etc., and achieve the effect of repairing bone defects

Active Publication Date: 2014-03-19
山东硅苑新材料科技股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the preparation of porous CPP at home and abroad mainly adopts the preparation process of melting→wire drawing→water quenching→drying→ethanol wet grinding→adding pore-forming agent to form→sintering. The disadvantage of this method is that it is easy to pollute the material and cause purity. It does not reach the medical level; the sintering system is also unable to control the interaction between the polymerization reaction, the crystal transformation temperature and the porous structure of the material, resulting in the failure to obtain ideal material properties, which limits the clinical research and application of CPP materials carry out

Method used

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  • Preparation method of porous calcium polyphosphate biological material
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Examples

Experimental program
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Effect test

Embodiment 1

[0024] Calcined calcium dihydrogen phosphate:

[0025] Use a balance to weigh 300g of powdered calcium dihydrogen phosphate, put it into a quartz crucible, cover it for protection, put it into an electric furnace, raise the temperature to 350°C at a rate of 4°C / m, keep it warm for 1 to 2 hours, and then cool it naturally to obtain loose powder. Block calcined material. After the calcined material is crushed with a mortar or ball mill, it is put into a drying box for later use.

[0026] Mix the calcined calcium dihydrogen phosphate with an appropriate amount of uncalcined calcium dihydrogen phosphate:

[0027] Weigh 80g of calcined material and 20g of powdered calcium dihydrogen phosphate, mix them evenly, and use a ball mill to dry ball mill for 1 minute, pass the prepared powder through 40-mesh and 80-mesh sieves, and take the sieve residue on the 80-mesh sieve , The particle size of the obtained powder is about 200-400 μm.

[0028] The mixture is sintered at high temperat...

Embodiment 2

[0031] Calcined calcium dihydrogen phosphate:

[0032] Use a balance to weigh 300g of powdered calcium dihydrogen phosphate, put it into a quartz crucible, cover it for protection, put it into an electric furnace, raise the temperature to 500°C at a rate of 4°C / m, keep it warm for 1 to 2 hours, and then cool it naturally to obtain loose powder. Block calcined material. After the calcined material is crushed with a mortar or ball mill, it is put into a drying box for later use.

[0033] Mix the calcined calcium dihydrogen phosphate with an appropriate amount of uncalcined calcium dihydrogen phosphate:

[0034] Weigh 80g of calcined material and 240g of powdered calcium dihydrogen phosphate, mix them evenly, and use a ball mill to dry ball mill for 1 minute, pass the prepared powder through 40 mesh and 120 mesh sieves, and take the sieve residue on 120 mesh sieves , The particle size of the obtained powder is about 100-400 μm.

[0035] The mixture is sintered at high temperat...

Embodiment 3

[0038] Calcined calcium dihydrogen phosphate:

[0039] Use a balance to weigh 300g of powdered calcium dihydrogen phosphate, put it into a quartz crucible, cover it for protection, put it into an electric furnace, raise the temperature to 300°C at a rate of 4°C / m, keep it warm for 1 to 2 hours, and then cool it naturally to obtain loose powder. Block calcined material. After the calcined material is crushed with a mortar or ball mill, it is put into a drying box for later use.

[0040] Weigh 80 g of the calcined material, dry ball mill for 1 minute with a ball mill, pass the obtained powder through a 120-mesh sieve, and the particle size of the obtained powder is about 100 μm.

[0041] The mixture is sintered at high temperature:

[0042] Put the prepared powder into the crucible and compact it, then put the crucible into the electric furnace for sintering. The heating rate is: 2°C / m from room temperature to 200°C, 4°C / m from 200°C to 970°C, heat preservation and sintering ...

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Abstract

The invention relates to a preparation method of a porous calcium polyphosphate biological material, belonging to the field of biomedical materials. The preparation method comprises the following steps: (1) calcining calcium dihydrogen phosphate; (2) uniformly mixing the calcined calcium dihydrogen phosphate with a proper amount of un-calcined calcium dihydrogen phosphate; and (3) sintering the mixture obtained in the step (2) at a high temperature. In the preparation method provided by the invention, based on the characteristic of high-temperature condensation polymerization, the calcium dihydrogen phosphate is poly-condensed to form pores, thus forming a porous calcium polyphosphate biological material for bone repair, thereby avoiding the introduction of other impurities and guaranteeing the purity of the material to the greatest extent.

Description

technical field [0001] The invention relates to a method for preparing a porous calcium polyphosphate biological material, belonging to the field of biomedical materials. Background technique [0002] Articular cartilage and bone defects caused by trauma, tumor, infection, congenital diseases and many other causes are very common in clinical practice, and its repair has always been one of the difficult problems in international orthopedic medicine. For a long time, bone defect repair mainly adopts autologous or allogeneic bone grafting, but there are serious defects in the source of autologous bone grafting, which adds extra trauma and cost to the patient, and lesions may occur at the bone harvesting site, and the available autologous bone source very limited. In terms of allogeneic transplantation, it is quite difficult and expensive in terms of material screening, processing, and storage. It is also prone to immune rejection, which may cause problems such as the introduct...

Claims

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Application Information

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IPC IPC(8): C04B35/447C04B35/622
Inventor 范长春郑凯刘德军岳剑单婷
Owner 山东硅苑新材料科技股份有限公司
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