Bcn two-dimensional nanosheet reinforced bioceramic scaffold and its preparation method and application

A two-dimensional nano and bio-scaffold technology, applied in the fields of nano-carbon, drug delivery, tissue regeneration, etc., can solve the problems that tumor lesions are difficult to completely remove, bone defect repair cannot be realized, and the recovery speed of patients is affected, achieving good repair effect, Good photothermal performance and biological activity, the effect of eliminating residual tumors

Active Publication Date: 2022-01-11
SHANGHAI NINTH PEOPLES HOSPITAL SHANGHAI JIAO TONG UNIV SCHOOL OF MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Clinically, limb salvage treatment for patients with bone tumors makes it difficult to completely remove tumor lesions, and the current radiotherapy and chemotherapy will cause great toxic and side effects to patients. Therefore, how to safely prevent the recurrence of osteosarcoma after surgery has become a clinical issue. challenging questions
In addition, in order to repair the bone defect caused by the resection of the lesion, bone graft materials are often used in clinical practice, including autogenous bone inactivation and replantation, artificial joint replacement and other methods to repair the damage. However, implant materials without biological activity will affect the recovery speed of patients
Photothermal therapy has shown great advantages as a safe and effective new therapy to kill tumors at specific sites. However, most of the currently commonly used photothermal agents lack biological activity and cannot repair bone defects.

Method used

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  • Bcn two-dimensional nanosheet reinforced bioceramic scaffold and its preparation method and application
  • Bcn two-dimensional nanosheet reinforced bioceramic scaffold and its preparation method and application
  • Bcn two-dimensional nanosheet reinforced bioceramic scaffold and its preparation method and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038] (1) 5g of boric acid was dissolved in deionized water at 80°C, then 0.5g of gelatin was added and stirred until evaporation and crystallization. The crystallized product was annealed in nitrogen at 900°C for 1 hour to obtain a crude material, which was refluxed for 2 hours and dialyzed for 3 days to finally obtain BCN nanosheet powder;

[0039] (2) BCN powder is ultrasonically dispersed in deionized water to obtain a BCN solution with a concentration of 0.25 mg / ml;

[0040] (3) 5.0g of AKT ceramic powder, mixed fully with 0.3g of sodium alginate (SA) and 3g of PF127 (20wt%), three-dimensionally printed AKT body;

[0041] (4) Calcining the AKT green body at 1350°C for 3 hours to obtain the AKT scaffold;

[0042] (5) Soak the AKT scaffold in 0.25mg / ml BCN solution for 3 times, 10 minutes each time, and dry it in an oven at 120°C after soaking each time; obtain an integrated biological scaffold reinforced by BCN two-dimensional nanosheets, referred to as 2.5BCN@AKT brack...

Embodiment 2

[0045] (1) 5g of boric acid was dissolved in deionized water at 80°C, then 0.5g of gelatin was added and stirred until evaporation and crystallization. The crystallized product was annealed in nitrogen at 900°C for 1 hour to obtain a crude material, which was refluxed for 2 hours and dialyzed for 3 days to finally obtain BCN nanosheet powder;

[0046] (2) BCN powder is ultrasonically dispersed in deionized water to obtain a BCN solution with a concentration of 0.50 mg / ml;

[0047] (3) 5.0g of AKT ceramic powder, mixed fully with 0.3g of sodium alginate (SA) and 3g of PF127 (20wt%), three-dimensionally printed AKT body;

[0048] (4) Calcining the AKT green body at 1350°C for 3 hours to obtain the AKT scaffold;

[0049] (5) Soak the AKT scaffold in 0.50mg / ml BCN solution for 3 times, 10 minutes each time, and dry it in an oven at 120°C after soaking each time; obtain an integrated biological scaffold reinforced by BCN two-dimensional nanosheets, referred to as 5BCN@AKT bracket; ...

Embodiment 3

[0052] (1) 5g of boric acid was dissolved in deionized water at 80°C, then 0.5g of gelatin was added and stirred until evaporation and crystallization. The crystallized product was annealed in nitrogen at 900°C for 1 hour to obtain a crude material, which was refluxed for 2 hours and dialyzed for 3 days to finally obtain BCN nanosheet powder;

[0053] (2) BCN powder is ultrasonically dispersed in deionized water to obtain a BCN solution with a concentration of 0.75 mg / ml;

[0054] (3) 5.0g of AKT ceramic powder, mixed fully with 0.3g of sodium alginate (SA) and 3g of PF127 (20wt%), three-dimensionally printed AKT body;

[0055] (4) Calcining the AKT green body at 1350°C for 3 hours to obtain the AKT scaffold;

[0056] (5) Soak the AKT scaffold in 0.75mg / ml BCN solution for 3 times, each time for 10 minutes, and dry it in an oven at 120°C after soaking each time; obtain an integrated biological scaffold reinforced by BCN two-dimensional nanosheets, referred to as 7.5BCN@AKT b...

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Abstract

The invention discloses an integrated biological support reinforced by BCN two-dimensional nanosheets, a preparation method and application thereof. The integrated biological scaffold includes BCN two-dimensional nanosheets and bioceramic scaffolds, and the BCN two-dimensional nanosheets are evenly coated on the surface of the bioceramic scaffolds to form the integrated biological scaffolds. The preparation method is as follows: preparing B / N co-doped BCN two-dimensional nanosheets; using three-dimensional printing technology to prepare the magnesian feldspar base support; soaking the magnesian feldspar base support in the BCN two-dimensional nanosheet solution, drying after soaking, and passing The times of immersion and the concentration of the BCN two-dimensional nanosheet solution were adjusted so that the coating thickness of the BCN was 1-5 μm, and the integrated biological scaffold reinforced by the BCN two-dimensional nanosheet was obtained. The BCN two-dimensional nanosheets used in the present invention are used as a new two-dimensional material for the first time in the fields of tumor treatment and bone defect repair. The integrated biological scaffold provided can play a dual role of eliminating residual tumors and repairing bone defects after tumor surgery.

Description

technical field [0001] The invention belongs to the technical field of biomaterials, and in particular relates to a bioceramic support reinforced by BCN two-dimensional nanosheets, a preparation method and application thereof. Background technique [0002] Osteosarcoma is one of the common malignant bone tumors. Surgical resection and combined chemotherapy / radiotherapy are still the main treatment methods at present. Clinically, limb salvage treatment for patients with bone tumors makes it difficult to completely remove tumor lesions, and the current radiotherapy and chemotherapy will cause great toxic and side effects to patients. Therefore, how to safely prevent the recurrence of osteosarcoma after surgery has become a clinical issue. challenging questions. In addition, in order to repair the bone defect caused by the resection of the lesion, bone graft materials are often used in clinical practice, including autogenous bone inactivation and replantation, artificial joint...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/30C04B35/22C04B35/622B33Y10/00B33Y70/10C04B41/85C01B32/15A61L27/50A61L27/54A61L27/02
CPCC04B35/22C04B35/622B33Y10/00B33Y70/10C04B41/85C04B41/5001C04B41/009C01B32/15A61L27/50A61L27/54A61L27/303A61L27/306A61L27/025A61L2430/02A61L2400/12A61L2300/416A61L2300/412A61L2300/606C04B41/4535
Inventor 王旭东赵灿灿林开利
Owner SHANGHAI NINTH PEOPLES HOSPITAL SHANGHAI JIAO TONG UNIV SCHOOL OF MEDICINE
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