Bcn two-dimensional nanosheet reinforced bioceramic scaffold and its preparation method and application
A two-dimensional nano and bio-scaffold technology, applied in the fields of nano-carbon, drug delivery, tissue regeneration, etc., can solve the problems that tumor lesions are difficult to completely remove, bone defect repair cannot be realized, and the recovery speed of patients is affected, achieving good repair effect, Good photothermal performance and biological activity, the effect of eliminating residual tumors
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Embodiment 1
[0038] (1) 5g of boric acid was dissolved in deionized water at 80°C, then 0.5g of gelatin was added and stirred until evaporation and crystallization. The crystallized product was annealed in nitrogen at 900°C for 1 hour to obtain a crude material, which was refluxed for 2 hours and dialyzed for 3 days to finally obtain BCN nanosheet powder;
[0039] (2) BCN powder is ultrasonically dispersed in deionized water to obtain a BCN solution with a concentration of 0.25 mg / ml;
[0040] (3) 5.0g of AKT ceramic powder, mixed fully with 0.3g of sodium alginate (SA) and 3g of PF127 (20wt%), three-dimensionally printed AKT body;
[0041] (4) Calcining the AKT green body at 1350°C for 3 hours to obtain the AKT scaffold;
[0042] (5) Soak the AKT scaffold in 0.25mg / ml BCN solution for 3 times, 10 minutes each time, and dry it in an oven at 120°C after soaking each time; obtain an integrated biological scaffold reinforced by BCN two-dimensional nanosheets, referred to as 2.5BCN@AKT brack...
Embodiment 2
[0045] (1) 5g of boric acid was dissolved in deionized water at 80°C, then 0.5g of gelatin was added and stirred until evaporation and crystallization. The crystallized product was annealed in nitrogen at 900°C for 1 hour to obtain a crude material, which was refluxed for 2 hours and dialyzed for 3 days to finally obtain BCN nanosheet powder;
[0046] (2) BCN powder is ultrasonically dispersed in deionized water to obtain a BCN solution with a concentration of 0.50 mg / ml;
[0047] (3) 5.0g of AKT ceramic powder, mixed fully with 0.3g of sodium alginate (SA) and 3g of PF127 (20wt%), three-dimensionally printed AKT body;
[0048] (4) Calcining the AKT green body at 1350°C for 3 hours to obtain the AKT scaffold;
[0049] (5) Soak the AKT scaffold in 0.50mg / ml BCN solution for 3 times, 10 minutes each time, and dry it in an oven at 120°C after soaking each time; obtain an integrated biological scaffold reinforced by BCN two-dimensional nanosheets, referred to as 5BCN@AKT bracket; ...
Embodiment 3
[0052] (1) 5g of boric acid was dissolved in deionized water at 80°C, then 0.5g of gelatin was added and stirred until evaporation and crystallization. The crystallized product was annealed in nitrogen at 900°C for 1 hour to obtain a crude material, which was refluxed for 2 hours and dialyzed for 3 days to finally obtain BCN nanosheet powder;
[0053] (2) BCN powder is ultrasonically dispersed in deionized water to obtain a BCN solution with a concentration of 0.75 mg / ml;
[0054] (3) 5.0g of AKT ceramic powder, mixed fully with 0.3g of sodium alginate (SA) and 3g of PF127 (20wt%), three-dimensionally printed AKT body;
[0055] (4) Calcining the AKT green body at 1350°C for 3 hours to obtain the AKT scaffold;
[0056] (5) Soak the AKT scaffold in 0.75mg / ml BCN solution for 3 times, each time for 10 minutes, and dry it in an oven at 120°C after soaking each time; obtain an integrated biological scaffold reinforced by BCN two-dimensional nanosheets, referred to as 7.5BCN@AKT b...
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