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Pharmaceutical composition containing lisinopril and amlodipine besylateand preparation method of pharmaceutical composition

A technology of amlodipine besylate and a composition, applied in the field of medicine, can solve the problems of low production efficiency, long drying time, low drying temperature and the like, and achieve the effects of high production efficiency, simple preparation process and good stability

Inactive Publication Date: 2014-03-26
HAINAN ZHONGJI MEDICAL TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

It adopts vacuum drying, which requires high equipment; low drying temperature leads to long drying time and low production efficiency

Method used

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  • Pharmaceutical composition containing lisinopril and amlodipine besylateand preparation method of pharmaceutical composition
  • Pharmaceutical composition containing lisinopril and amlodipine besylateand preparation method of pharmaceutical composition
  • Pharmaceutical composition containing lisinopril and amlodipine besylateand preparation method of pharmaceutical composition

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] Embodiment 1: Preparation of Lisinopril Amlodipine Tablets

[0034] 1. Prescription

[0035]

[0036] 2. Preparation method

[0037] (1) Pulverize lisinopril and amlodipine besylate respectively, pass through an 80-mesh sieve, and set aside;

[0038] (2) microcrystalline cellulose, sodium carboxymethyl starch, micropowder silica gel and magnesium stearate are passed through a 60-mesh sieve respectively, and set aside;

[0039] (3) Lisinopril, amlodipine besylate, microcrystalline cellulose, sodium carboxymethyl starch, micropowder silica gel and magnesium stearate of 2 / 3 prescription quantity are taken by weighing prescription quantity, mix;

[0040] (4) the mixed material that step (3) is obtained is crossed 40 mesh sieves;

[0041] (5) mixing the sieved material in step (4);

[0042] (6) the mixed material obtained in step (5) is granulated by a dry granulator;

[0043] (7) take by weighing the magnesium stearate of 1 / 3 recipe quantity, join in the granule tha...

Embodiment 2

[0045] Embodiment 2: Preparation of Lisinopril Amlodipine Tablets

[0046] 1. Prescription

[0047]

[0048] 2. Preparation method

[0049] (1) Pulverize lisinopril and amlodipine besylate respectively, pass through a 100-mesh sieve, and set aside;

[0050] (2) Microcrystalline cellulose, sodium carboxymethyl starch, micropowder silica gel and magnesium stearate are passed through a 50-mesh sieve respectively, and set aside;

[0051] (3) Lisinopril, amlodipine besylate, microcrystalline cellulose, sodium carboxymethyl starch, micropowder silica gel and magnesium stearate of 2 / 3 prescription quantity are taken by weighing prescription quantity, mix;

[0052] (4) the mixed material that step (3) is obtained is crossed 50 mesh sieves;

[0053] (5) mixing the sieved material in step (4);

[0054] (6) the mixed material obtained in step (5) is granulated by a dry granulator;

[0055] (7) take by weighing the magnesium stearate of 1 / 3 recipe quantity, join in the granule tha...

Embodiment 3

[0057] Embodiment 3: the preparation of lisinopril amlodipine tablet

[0058] 1. Prescription

[0059]

[0060] 2. Preparation method

[0061] (1) Pulverize lisinopril and amlodipine besylate respectively, pass through a 120 mesh sieve, and set aside;

[0062] (2) microcrystalline cellulose, sodium carboxymethyl starch, micropowder silica gel and magnesium stearate are passed through a 60-mesh sieve respectively, and set aside;

[0063] (3) Lisinopril, amlodipine besylate, microcrystalline cellulose, sodium carboxymethyl starch, micropowder silica gel and magnesium stearate of 2 / 3 prescription quantity are taken by weighing prescription quantity, mix;

[0064] (4) the mixed material that step (3) is obtained is crossed 60 mesh sieves;

[0065] (5) mixing the sieved material in step (4);

[0066] (6) the mixed material obtained in step (5) is granulated by a dry granulator;

[0067] (7) take by weighing the magnesium stearate of 1 / 3 recipe quantity, join in the granule ...

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Abstract

The invention belongs to the technical field of medicines, and particularly relates to a pharmaceutical composition containing lisinopril and amlodipine besylate and a preparation method of the pharmaceutical composition. The pharmaceutical composition comprises the following components in parts by weight: 10 parts of lisinopril, 5 parts of amlodipine besylate (based on the weight of amlodipine), 100-200 parts of microcrystalline cellulose, 6-10 parts of sodium carboxymethyl starch, 1-3 parts of fumed silica and 2-4 parts of magnesium stearate. The pharmaceutical composition is prepared by using a dry granulating tableting process. The pharmaceutical composition has reasonable formula and good stability. The preparation method is simple in process and high in production efficiency; the preparation process of the pharmaceutical composition does not cause the increase of impurity content; the content uniformity of the prepared pharmaceutical composition is good.

Description

technical field [0001] The invention belongs to the technical field of medicine, and relates to a pharmaceutical composition containing lisinopril and amlodipine besylate and a preparation method thereof. Background technique [0002] Hypertension is the most important risk factor leading to the occurrence and death of heart disease, cerebrovascular disease, and kidney disease. The purpose of antihypertensive drug therapy for hypertensive patients is to effectively prevent or delay stroke, myocardial infarction, The occurrence of cardiovascular and cerebrovascular complications such as heart failure and renal insufficiency can effectively control the disease process of hypertension and prevent the occurrence of severe hypertension such as hypertensive emergencies and sub-emergencies. [0003] Commonly used antihypertensive drugs include calcium channel blockers (CCBs), angiotensin-converting enzyme inhibitors (ACEIs), angiotensin receptor blockers (ARBs), diuretics, and β-bl...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K38/05A61K47/38A61P9/12A61K31/4422
Inventor 刘启兵杨贵方肖文礼章燕杨波
Owner HAINAN ZHONGJI MEDICAL TECH
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