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Cranberry extraction method

An extraction method, cranberry technology, applied in the direction of organic chemistry, can solve the problems of component damage, high cost, increased production cost, etc., and achieve the effect of complete separation, reduced loss, and low production cost

Active Publication Date: 2014-03-26
NINGBO GREEN HEALTH PHARMACEUTICAL CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Fan Jianli et al. disclosed an invention patent for an extraction method of anthocyanins and proanthocyanidins in cranberry fruit. They used enzymatic hydrolysis, water extraction, resin adsorption, evaporation and concentration to extract, but the anthocyanins were easily oxidized. , and it is a heat-sensitive substance, evaporation and concentration will lead to the destruction of its components, and the use of enzymatic hydrolysis will increase the production cost
Sun Huageng published an invention patent for extracting and isolating malvalin-3-o-glucoside from cranberry, using alcohol extraction and two times of resin adsorption to separate and purify. This method is too expensive and not suitable for large-scale production

Method used

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Examples

Experimental program
Comparison scheme
Effect test

example 1

[0025] (1) Extraction steps: Crush 100kg of cranberry raw materials, add 4 times the volume (V / M) of water for extraction, and add hydrochloric acid with a volume percentage of 30%, adjust the pH at 2, and stir and extract at 40°C.

[0026] (2) Centrifugation step: use a centrifuge for centrifugation and collect the centrifugate.

[0027] (3) Resin adsorption step: the centrifugate is passed through the macroporous resin, and the amount of resin and the raw material are in the ratio of 1:1 (M / M). After the adsorption is complete, wash with water until the effluent is colorless, then desorb with 70% ethanol solution, collect the desorption liquid, and stop the desorption until the effluent is colorless.

[0028] (4) Membrane concentration step: Concentrate the desorbed solution through a 1nm nanofiltration membrane at room temperature.

[0029] (5) Spray-drying step: the concentrated solution is sterilized by a ceramic composite membrane, and then spray-dried. Control the spr...

example 2

[0031] (1) Extraction steps: Crush 100kg of cranberry raw materials and add 4 times the amount (V / M) of ethanol for extraction. At the same time, add hydrochloric acid with a volume percentage of 30%, adjust the pH to 1.5, and stir and extract at 41°C .

[0032] (2) Centrifugation step: use a centrifuge for centrifugation and collect the centrifugate.

[0033] (3) Resin adsorption step: the centrifugate is passed through the macroporous resin, and the amount of resin and the raw material are in the ratio of 1:1 (M / M). After the adsorption is complete, wash with water until the effluent is colorless, then desorb with 75% ethanol solution, collect the desorption liquid, and stop the desorption until the effluent is colorless.

[0034] (4) Membrane concentration step: Concentrate the desorbed solution through a 0.5nm nanofiltration membrane at room temperature.

[0035] (5) Spray-drying step: the concentrated solution is sterilized by a ceramic composite membrane, and then spra...

example 3

[0037] (1) Extraction steps: Crush 100kg of cranberry raw materials, add 5 times the volume (V / M) of water for extraction, and add 30% citric acid at the same time, adjust the pH to 2.5, stir and extract at 42°C .

[0038] (2) Centrifugation step: use a centrifuge for centrifugation and collect the centrifugate.

[0039] (3) Resin adsorption step: The centrifugal liquid is adsorbed by the resin through the macropores, and the amount of the resin and the raw material are packed in a certain ratio (M / M). After the adsorption is complete, wash with water until the effluent is colorless, then desorb with 80% ethanol solution, collect the desorption liquid, and stop the desorption until the effluent is colorless.

[0040] (4) Membrane concentration step: Concentrate the desorbed solution through a 2nm nanofiltration membrane at room temperature.

[0041] (5) Spray-drying step: the concentrated solution is sterilized by a ceramic composite membrane, and then spray-dried. Control ...

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PUM

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Abstract

The invention discloses a cranberry extraction method which comprises the following steps: (1) extraction; (2) centrifugation; (3) resin adsorption; (4) membrane concentration; (5) spray drying. The cranberry extraction method has the advantages that the production cost is low, the effective constituents of a product can not be damaged by high temperature, the pH value is regulated to be acidic during the process of extraction, so that original anthocyanidin stays in a stable ionic state, loss during the process of extraction is lowered, the utilization rate of raw material is high, and large-scale production is facilitated.

Description

[0001] technical field [0002] The invention belongs to the technical field of medicine purification, in particular to a cranberry extraction method. Background technique [0003] Cranberry is the common name of the subgenus cranberry moss (scientific name: Oxycoccos), also known as Artemisia subgenus of the Rhododendronaceae Vaccinium. The species of this subgenus are all evergreen shrubs and mainly grow in the cool areas of the northern hemisphere. in acidic peat soils. Cranberries are rich in flavonoids, which contain a special compound concentrated tannic acid. In addition to being generally believed to have the function of preventing urinary tract infection, it can also effectively inhibit Helicobacter pylori from attaching to the stomach and reduce the risk of gastric ulcer and gastric cancer. incidence. [0004] In 2004, the French pharmatoka company submitted to the French food authority the health claim that the cranberry protects the urinary tract was approv...

Claims

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Application Information

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IPC IPC(8): C07D311/62
CPCC07D311/62
Inventor 戴珊媛
Owner NINGBO GREEN HEALTH PHARMACEUTICAL CO LTD
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