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Improvement method of compound glycyrrhiza oral solution production technology

A technology of licorice oral liquid and production process, which can be applied to pharmaceutical formulations, medical preparations without active ingredients, and medical preparations containing active ingredients, etc. problems, to achieve the effect of reducing precipitates, maintaining chemical balance, and reducing surface tension

Inactive Publication Date: 2014-04-02
GUANGXI NANNING BAIHUI PHARMA GRP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The purpose of the present invention is to provide a method for improving the production process of compound licorice oral liquid for the problems of easy precipitation, deterioration and unstable product quality in the storage process of compound licorice oral liquid

Method used

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  • Improvement method of compound glycyrrhiza oral solution production technology

Examples

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Effect test

Embodiment 1

[0016] An improved method for the production process of compound licorice oral liquid, comprising the following steps:

[0017] 1. Take 1200ml of licorice liquid extract, add 1200ml of glycerin, mix well, add 5000ml of water to dilute, then slowly add an appropriate amount of concentrated ammonia solution, adjust the pH value to 8.00, and obtain the licorice liquid extract solution;

[0018] 2. Take 50g of guaiacol glycerin ether, add appropriate amount of hot water to dissolve, and make guaiacol glycerin ether solution;

[0019] 3. Add guaiacol glyceryl ether solution to the liquid extract solution of licorice, stir as it is added, then add 100 g of sodium alginate and 50 g of sodium carboxymethyl cellulose, stir to dissolve, and obtain a mixed solution;

[0020] 4. Add 1800ml of compound camphor tincture to the mixed solution, stir well, slowly add an appropriate amount of concentrated ammonia solution, adjust the pH value of the solution to 8.00, add appropriate amount of w...

Embodiment 2

[0022] An improved method for the production process of compound licorice oral liquid, comprising the following steps:

[0023] 1. Take 1200ml of licorice liquid extract, add 1200ml of glycerin, mix well, add 5000ml of water to dilute, slowly add an appropriate amount of concentrated ammonia solution, adjust the pH value to 9.00, and obtain the licorice liquid extract solution;

[0024] 2. Take 50g of guaiacol glycerin ether, add appropriate amount of hot water to dissolve, and make guaiacol glycerin ether solution;

[0025] 3. Add guaiacol glyceryl ether solution to the liquid extract solution of licorice, stir as it is added, then add 100 g of sodium alginate and 50 g of sodium carboxymethyl cellulose, stir to dissolve, and obtain a mixed solution;

[0026] 4. Add 1800ml of compound camphor tincture to the mixed solution, stir well, slowly add an appropriate amount of concentrated ammonia solution, adjust the pH value of the solution to 8.50, add appropriate amount of water ...

Embodiment 3

[0028] An improved method for the production process of compound licorice oral liquid, comprising the following steps:

[0029] 1. Take 1200ml of licorice liquid extract, add 1200ml of glycerin, mix well, add 5000ml of water to dilute, slowly add an appropriate amount of concentrated ammonia solution, adjust the pH value to 8.50, and obtain the licorice liquid extract solution;

[0030] 2. Take 50g of guaiacol glycerin ether, add appropriate amount of hot water to dissolve, and make guaiacol glycerin ether solution;

[0031] 3. Add guaiacol glyceryl ether solution to the liquid extract solution of licorice, stir as it is added, then add 100 g of sodium alginate and 50 g of sodium carboxymethyl cellulose, stir to dissolve, and obtain a mixed solution;

[0032] 4. Add 1800ml of compound camphor tincture to the mixed solution, stir well, slowly add an appropriate amount of concentrated ammonia solution, adjust the pH value of the solution to 8.30, add appropriate amount of water ...

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Abstract

The invention discloses an improvement method of a compound glycyrrhiza oral solution production technology. The method comprises the steps of by taking 120ml of extractum glycyrrhizae liquidum, adding 120ml of glycerinum, evenly mixing, adding 500ml of water and diluting; then adding a proper amount of concentrated ammonia solution, and adjusting the pH value to be 8.00-9.00 to obtain an extractum glycyrrhizae liquidum solution; taking 5g of guaiacol glycerol ether, and adding a proper amount of hot water for dissolving to obtain guaiacol glycerol ether solution; adding the guaiacol glycerol ether solution into the extractum glycyrrhizae liquidum solution and stirring at the same time, adding 10g of sodium alginate and 5g of sodium carboxymethyl cellulose, and stirring for dissolving to obtain mixed solution; adding 180ml of compound camphor tineture into the mixed solution, evenly stirring, slowing adding right amount of concentrated ammonia solution, adjusting the pH value of the solution to be 8.00-8.50, and then adding a proper amount of water to form 1000ml of solution; evenly stirring, filtering and carrying sterilization to obtain the compound glycyrrhiza oral solution. The method solves the problems that the compound glycyrrhiza oral solution is easy to precipitate, easily goes bad, is unstable in product quality, etc.

Description

technical field [0001] The invention belongs to the field of medicines and relates to an improved method for the production process of compound licorice oral liquid. Background technique [0002] Compound Glycyrrhiza Oral Liquid was recorded in the 2010 edition of "Chinese Pharmacopoeia". , the prescription was changed to licorice liquid extract, compound camphor tincture, and guaiacol glyceryl ether, of which licorice liquid extract is a protective expectorant; compound camphor tincture is an antitussive; guaiacol glyceryl ether is an expectorant and cough suppressant. It has a certain antiseptic effect; studies have shown that camphor, opium tincture, benzoic acid, and star anise oil are combined to make compound camphor tincture in the adjusted prescription, and its dosage is increased, and guaiacol glycerin is added Ether, the antitussive and expectorant effects are indeed better than the original prescription; although the prescription increases the content of dependen...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/57A61K47/04A61K47/36A61K47/38A61P11/10A61P11/14A61K31/125A61K31/192A61K31/09
Inventor 周健黄斌
Owner GUANGXI NANNING BAIHUI PHARMA GRP
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