Application of Dicarboxylic Acid and Its Esters

A compound and drug technology, applied in the application field of preparing neuroprotective drugs, can solve the problems of clinical application, poor effect, side effects, etc.
CN103705499BInactive Publication Date: 2015-11-18NANJING MEDICAL UNIV
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
NANJING MEDICAL UNIV
Publication Date
2015-11-18
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention provides an application of dicarboxylic acid and ester compounds thereof and in particular relates to an application of the compounds to preparation of neuroprotective drugs. In a chemical formula in the specification, R1 is hydrogen or methyl; R2 is isopropyl or isobutyl; R3 is carboxyl, methoxycarbonyl, ethoxycarbonyl, propoxycarbonyl, isopropoxycarbonyl, borneol oxycarbonyl or 5-tetrazole; a is 0 or 1; b is 0 or 1; c is an integer from 1 to 4; b is 0 when a is 0; b is 0 or 1 when a is 1. The compounds have relatively strong protective effects on glutamate-induced neuron damages.
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Description

Technical field

[0001] The invention belongs to the field of pharmacy and provides applications of a class of dicarboxylic acids and their ester compounds in the preparation of neuroprotective drugs. Background technique

[0002] Neuroprotective agents are a hot spot in the development of therapeutic drugs for ischemic stroke. At present, many protective reagents developed for different stages of the cerebral infarction cascade, except for the free radical scavenger edaravone, are all effective in animals, and are clinically ineffective or poorly effective, or cannot be used in clinical practice due to severe side effects. Therefore, the development and screening of new neuroprotective agents is the focus of current research.

[0003] Glutamate is released in large quantities when cerebral ischemia occurs. A large amount of released glutamate activates N-methylaspartate (NMDA) receptors, and calcium ions flowing from NMDA receptors activate neuronal nitric oxide synthase (nNOS) a...

Claims

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