Nasal polymer gel filling material and preparation method thereof

A technology of polymer gel and packing material, which is applied in the field of nasal polymer gel packing material and its preparation, can solve the problems of slowing down the healing speed of wounds in the nasal cavity, patients' nasal swelling and pain, and nasal bleeding, etc., so as to improve the anti-inflammatory Effect, improve the cure rate, not easy to nasal adhesion effect

Active Publication Date: 2014-04-09
深圳市博立生物材料有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, after the oiled vaseline gauze is stuffed into the nasal cavity, it is easy to cause the patient's nasal cavity pain, headache, ear fullness, irritability, difficulty in falling asleep, etc.; Can cause profuse bleeding in the nasal cavity, which slows down the healing of wounds in the nasal cavity
In addition, if the vaseline oil gauze is stuffed for more than 48 hours, it is easy to cause nasal cavity and sinus infection

Method used

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Examples

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Effect test

preparation example Construction

[0031] In one embodiment of the present invention, a method for preparing the above-mentioned nasal polymer gel packing material is also provided, including:

[0032] adding the cross-linking agent into the aqueous solution of the gel to obtain a mixed solution, wherein the aqueous solution of the gel has a mass percent concentration of 0.1%-10%;

[0033] Under the temperature condition of 40-80°C, the cross-linking reaction is carried out to obtain a modified gel;

[0034] The modified gel obtained above is soaked in distilled water for 12-48 hours, the water is changed every 2 hours, and then freeze-dried to obtain a nasal polymer gel packing material.

[0035] Wherein, the step of immersing the modified gel obtained above in distilled water for 12-48 hours, and changing the water every 2 hours is to cross-link the modified gel that has not participated in the cross-linking reaction and remains in the modified gel. agent removed.

[0036] Wherein, freeze-drying can be oper...

Embodiment 1

[0055] A nasal polymer gel packing material, prepared from the following raw materials:

[0056] Chitosan and oxidized ammonium alginate with a number average molecular weight of 10,000;

[0057] Prepare as follows:

[0058] Prepare an aqueous solution of ammonium alginate with a mass percentage concentration of 0.1%, mix sodium periodate with a mass of 10% of the mass of ammonium alginate with an aqueous solution of ammonium alginate, and react at room temperature in the dark for 12 hours, and terminate the reaction-precipitation-dissolution- Precipitation-dissolution-precipitation-freeze drying to obtain oxidized ammonium alginate;

[0059] Preparation mass percentage concentration is the aqueous solution of 5% chitosan,

[0060] Add the oxidized ammonium alginate obtained above into the aqueous solution of chitosan to obtain a mixed solution, wherein the quality of the oxidized ammonium alginate is 1% of the mass of chitosan;

[0061] Under the temperature condition of 4...

Embodiment 2

[0064] A nasal polymer gel packing material, prepared from the following raw materials:

[0065] Chitosan with a number average molecular weight of 500,000 and oxidized potassium alginate;

[0066] Prepare as follows:

[0067] Prepare a potassium alginate aqueous solution with a mass percentage concentration of 6%, mix sodium periodate and potassium alginate aqueous solution with a mass of 15% of the mass of potassium alginate, and react at room temperature in the dark for 48 hours, and terminate the reaction-precipitation-dissolution- Precipitation-dissolution-precipitation-freeze drying to obtain oxidized potassium alginate;

[0068] Preparation mass percentage concentration is the aqueous solution of 0.1% chitosan,

[0069] The oxidized potassium alginate obtained above is added to the aqueous solution of chitosan to obtain a mixed solution, wherein the quality of the oxidized potassium alginate is 0.1% of the mass of chitosan;

[0070] Under the temperature condition of...

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PUM

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Abstract

The invention discloses a nasal polymer gel filling material and a preparation method thereof. The nasal polymer gel filling material is prepared from the following raw materials: gel and a crosslinking agent which is 0.1-2% of the mass of the gel. The preparation method comprises the following steps: adding the crosslinking agent to a water solution of gel to obtain a mixed solution; carrying out crosslinking reaction under the condition at 40-80 DEG C to obtain modified gel; soaking the modified gel into distilled water for 12-48 hours; replacing the water once at an interval of two hours; and carrying out freeze drying, so as to obtain the nasal polymer gel filling material. The gel filling material forms a compressed state when being placed, and is easy to put in, and light in adhesion with tissues, so that the expanded filling material is soft, and not easy to be extracted, and does not lead to adhesion of a nasal cavity. The inhibition ratio of the filling material on microorganisms such as staphylococcus aureus and escherichia coli can be up to over 90%, prevention of local infection is facilitated, and the anti-inflammatory action after chronic sinusitis-nasosinusitis surgery is improved.

Description

technical field [0001] The invention relates to the field of medical biopolymer materials, in particular to a nasal polymer gel packing material and a preparation method thereof. Background technique [0002] Epistaxis is one of the common emergencies in otolaryngology. Nasal packing is the most commonly used and effective method to prevent and treat epistaxis. [0003] In the related art, the commonly used stuffing material for nasal cavity is vaseline gauze. However, after the oiled vaseline gauze is stuffed into the nasal cavity, it is easy to cause the patient's nasal cavity pain, headache, ear fullness, irritability, difficulty in falling asleep, etc.; It can cause profuse bleeding in the nasal cavity, which slows down the healing of wounds in the nasal cavity. In addition, if the vaseline oil gauze is stuffed for more than 48 hours, it is easy to cause nasal cavity and sinus infection. Contents of the invention [0004] The object of the present invention is to pr...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L31/04A61L31/16C08J3/24C08B37/08C08B37/04
Inventor 张平
Owner 深圳市博立生物材料有限公司
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