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Method for extracting vitexin from sandalwood leaves

A technology of sandalwood leaves and vitexin, which is applied in the field of extracting target components, can solve the problems of large investment in fixed assets, high production costs, and unfavorable industrial production.

Active Publication Date: 2014-04-30
林翔
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] At present, vitexin is extracted by using high-end equipment and fillers such as preparative, semi-preparative liquid phase, and countercurrent chromatography. The investment in fixed assets is large, and the amount of each acquisition is only g-level. The production process does not consider cost factors, and the investment in fixed assets is deducted. The production cost is much higher than the commodity market price, which is not conducive to industrial production

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] Newly harvested sandalwood leaves in May, put them into the net cage on the spot, wash with running water to remove the sediment, drain the water vapor from the net frame, expose to the sun until dry, and crush it through a 1cm*1cm steel net; take 100kg of crushed leaves and add 500L of 70% methanol aqueous solution, Stirring speed 1 second / rotation, soaking at 40°C for 0.5h, maintaining the stirring speed, reflux heating to boiling state, maintaining slight boiling for 0.75h, and repeating the above extraction steps once; combine the extracts, and use a 20-mesh steel mesh while hot, 200-mesh filter bag, 1000-mesh filter bag, 2000-mesh filter bag to filter and collect the filtrate;

[0023] Evaporate to dryness with a rotary evaporator; add 50L of hot water at 70°C to the dry extract, stir and suspend it with ultrasound, press it through a 150-mesh steel sieve while it is hot, let it cool to room temperature, and adjust the pH value to 2 with 10% hydrochloric acid;

[0...

Embodiment 2

[0027] Harvest sandalwood leaves in June, put them into net cages on the spot, wash them with running water to remove sediment, drain the water vapor from the grid racks, expose them to the sun until they are dry, and crush them through 1cm*1cm steel mesh; take 100kg of crushed leaves and add 600L of 80% methanol aqueous solution, stir Speed ​​at 2 seconds / rev, soak at 45°C for 1 hour, maintain stirring speed, reflux and heat to boiling state, maintain slight boiling for 1 hour, then repeat the above extraction steps once; combine the extracts, filter them with 20-mesh steel mesh and 200-mesh steel mesh while they are hot Filter with cloth bag, 1000-mesh filter bag, 2000-mesh filter bag, collect the filtrate, and evaporate to dryness with a rotary evaporator; add 40L of hot water at 80°C to the dry extract, stir and suspend with ultrasonic, press it through a 150-mesh steel sieve while it is hot, and let it cool to room temperature , adjust the pH value to 3 with 10% hydrochlor...

Embodiment 3

[0029] Freshly harvested sandalwood leaves in July, put them into the net cage on the spot, rinse with running water to remove the sediment, drain the water vapor from the net rack, dry in an electric oven with blowing wind at 70°C, and crush them through a 1cm*1cm steel net; take 100kg of crushed leaves and add 90% methanol Aqueous solution 700L, stirring speed 3 seconds / rev, soaking at 50°C for 1.5h, maintaining stirring speed, heating under reflux to boiling state, maintaining slight boiling for 1.5h, and repeating the above extraction steps once; combine extracts, use 20 meshes while hot Steel mesh, 200-mesh filter bag, 1000-mesh filter bag, 2000-mesh filter bag to filter, collect the filtrate, and evaporate to dryness with a rotary evaporator; add 30L of 90°C hot water to the dry extract, stir and suspend with ultrasonic, and press it through 150-mesh steel while hot Sieve, let cool to room temperature, adjust the pH value to 4 with 10% hydrochloric acid, and extract with ...

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PUM

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Abstract

The invention relates to a method for extracting vitexin from sandalwood leaves, which comprises the following steps: (1) taking sandalwood leaves, washing with water, drying, pulverizing, adding a methanol solution, immersing, extracting under reflux 1-3 times, merging the extracting solutions, and filtering to obtain a filtrate; (2) drying the filtrate by distillation to obtain a dry extractum, adding 50-95 DEG C hot water into the dry extractum to obtain a suspension, and regulating the pH value to an acidic state; (3) extracting with an organic solvent 1-3 times, discarding the supernate, and taking the middle emulsion layer for later use; enhancing the alcohol concentration of the understratum suspension with methanol, carrying out ultrasonic treatment, standing, and mixing the understratum precipitate-containing solution with the middle emulsion layer; carrying out vacuum filtration; and (4) washing the precipitate obtained after vacuum filtration, dissolving in an ethanol solution under reflux, filtering, recrystallizing, and carrying out vacuum filtration to obtain the vitexin. The method has the advantages of simple technique and low production cost; and the vitexin yield can achieve more than 75% of the theoretical content of vitexin.

Description

technical field [0001] The invention relates to a process for extracting target components from plants, in particular to a method for extracting vitexin from sandalwood leaves. Background technique [0002] Sandalwood is a plant in the family Sandalaceae Santalum album L., evergreen small tree, 6-9 meters high, with parasitic roots. Leaves elliptic-ovate, membranous, 4-8 cm long, 2-4 cm wide, apex acute, base cuneate or broadly cuneate. [0003] At present, vitexin is extracted by using high-end equipment and fillers such as preparative, semi-preparative liquid phase, and countercurrent chromatography. The investment in fixed assets is large, and the amount of each acquisition is only g level. The production process does not consider cost factors, and the investment in fixed assets is deducted. The production cost outside is far higher than the commodity market price, is unfavorable for industrialized production. Contents of the invention [0004] In order to overcome ...

Claims

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Application Information

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IPC IPC(8): C07D407/04
CPCC07D407/04
Inventor 林励帅欧吴泽青
Owner 林翔
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