Optical fiber surface plasmon resonance sensor, detection system and method
A detection system and detection method technology, which is applied in the direction of instruments, measuring devices, scientific instruments, etc., can solve the problems of insufficient optical fiber SPR detection performance and reliability, and achieve the effects of simple and reliable, suppressing light source noise, and reducing the detection limit
Active Publication Date: 2017-01-04
SHENZHEN UNIV
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[0003] In view of this, the main purpose of the present invention is to provide an optical fiber SPR sensor, detection system and method, which can solve the problems of insufficient detection performance and reliability of the existing optical fiber SPR
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[0019] In order to make the object, technical solution and advantages of the present invention clearer, the present invention will be further described in detail by citing the following embodiments and referring to the accompanying drawings.
[0020] figure 1 The structure of the optical fiber SPR detection system of the present invention is shown, as figure 1 As shown, the optical fiber SPR detection system sequentially includes along the optical path direction: a light source, a polarizer, a phase retarder, a collimator, a sample cell, the above-mentioned optical fiber SPR sensor, a polarizer, a detector, a lock-in amplifier and PC systems.
[0021] The optical fiber SPR sensor is immersed in a sample pool full of the solution to be detected, the sample pool is provided with a liquid inlet and a liquid outlet, and the solution to be detected continuously flows in from the liquid inlet and flows out from the liquid outlet during detection; The optical fiber SPR sensor inclu...
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Abstract
The invention provides an optical fiber SPR sensor, a detection system and a detection method. The optical fiber SPR sensor includes an all-solid-state refractive index-guided photonic crystal fiber with a plane wall and a curved side wall. The cross-section of the all-solid-state refractive-index-guided photonic crystal fiber is D-shaped, and the plane wall has a sensing layer. The invention prepares a sensing plane on the surface of a D-shaped photonic crystal fiber, adjusts the excitation intensity of surface plasmon resonance by controlling the distance between the SPR sensing plane and the fiber core, and utilizes the interference of horizontal and vertical components of electromagnetic waves to realize phase sensitive measurement. The preparation process of the sensor is simple and reliable, the sensitivity is very high, the anti-interference ability is strong, and the resolution is much better than the optical fiber surface plasmon resonance detection device of the traditional wavelength demodulation method, so it has strong application value.
Description
technical field [0001] The invention relates to the technical field of photoelectric detection, in particular to an optical fiber surface plasmon resonance (Surface Plasmon Resonance, SPR) sensor, detection system and method. Background technique [0002] SPR is a new sensing technology, which has the advantages of high sensitivity, high throughput, easy to achieve specific detection and real-time performance, and does not require labeling. It has been widely used in biology, medicine, food quality and safety, chemical and environmental monitoring, etc. Industry, especially online real-time detection of interactions between DNA and proteins, between protein molecules, and between biomolecules such as drug-protein, nucleic acid-nucleic acid, antigen-antibody, receptor-ligand, etc. At present, the SPR demodulation based on optical fiber mainly adopts the wavelength demodulation method. Since the wavelength shift is an apparent and overall SPR effect, its detection performance ...
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IPC IPC(8): G01N21/552
CPCG01N21/553G01N21/05
Inventor 谭志新李学金邵永红
Owner SHENZHEN UNIV