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A method for preparing Panax notoginseng saponins by membrane coupling technology

A combination technology of Panax notoginseng saponins, which is applied to medical preparations containing active ingredients, pharmaceutical formulas, plant raw materials, etc., can solve the problems of low production efficiency, resin shedding pollution and pollution in Panax notoginseng saponins, etc. Achieve high production efficiency, no organic reagent pollution and residue, simple and feasible method

Active Publication Date: 2017-09-05
NANJING UNIVERSITY OF TRADITIONAL CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The content of Panax notoginseng total saponins in the rhizomes and leaves of Panax notoginseng medicinal materials is relatively high. At present, techniques such as macroporous resin method, anion (cation) ion exchange resin method or preparative chromatography are used to produce Panax notoginseng total saponins, but there are Many problems, such as pollution of organic reagents, shedding pollution of resin in Panax notoginseng saponins, low production efficiency, etc.

Method used

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  • A method for preparing Panax notoginseng saponins by membrane coupling technology
  • A method for preparing Panax notoginseng saponins by membrane coupling technology

Examples

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Effect test

Embodiment 1

[0020] Take 1 kg of Panax notoginseng medicinal material, crush it into coarse powder, add 8% gelatin, add 8 times the amount of ethanol solution with a concentration of 50%, reflux extraction twice, each time for 2 hours, combine the extracts, and recover under reduced pressure at 70°C. Filter and collect the filtrate, that is, too. Take the Panax notoginseng extract, filter it with a plate-and-frame ultrafiltration membrane made of improved cellulose material and a molecular weight cut-off of 100KDa, collect the ultrafiltrate, and then filter it with a nanofiltration membrane made of composite polyamide and a molecular weight cut-off of 500Da to collect the nanofiltration concentrate (relative density 1.5g / mL), dry, that is.

[0021] Content detection: According to the detection conditions of high performance liquid chromatography of the total saponins extract of Notoginseng in the 2010 edition of "Chinese Pharmacopoeia", this product is calculated as a dry product, and the ...

Embodiment 2

[0023] Take 1 kg of Panax notoginseng medicinal material, crush it into coarse powder, add 5% gelatin, add 8 times the amount of ethanol solution with a concentration of 70%, reflux extraction 3 times, each time for 1 hour, combine the extracts, and recover under reduced pressure at 70 ° C. Filter and collect the filtrate, that is, too. Take the Panax notoginseng extract, filter it with a plate-and-frame ultrafiltration membrane made of improved cellulose material and a molecular weight cut-off of 200KDa, collect the ultrafiltrate, and then filter it with a nanofiltration membrane made of composite polyamide and a molecular weight cut-off of 800Da to collect the nanofiltration concentrate (relative density 1.3g / mL), dry, that is.

[0024] Content detection: according to the detection conditions of high performance liquid chromatography of the total saponins of Panax notoginseng in the 2010 edition of "Chinese Pharmacopoeia", this product is calculated as a dry product, and the...

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Abstract

The invention discloses a method for preparing panax notoginseng saponins by adopting a membrane coupling technology. The method particularly comprises the following steps: taking a pseudo-ginseng extracting solution; filtering by adopting an ultrafiltration membrane with the molecular weight cutoff of 10-200 KDa, and collecting an ultrafiltrate; and filtering by adopting a nanofiltration membrane with the molecular weight cutoff of 100-1000 Da, collecting a nanofiltration concentrated solution, and drying to obtain the panax notoginseng saponins. According to the method disclosed by the invention, the ultrafiltration membrane with a proper aperture is selected to carry out ultrafiltration to remove large molecules and then coupled with the nanofiltration membrane to remove small molecular components based on the facts that the panax notoginseng saponins have surface activity property, exist in a solution mostly in an associated colloidal particle form and are obviously different from the molecular weight distribution and grain diameter characteristic of other types of components, so that the preparation of the panax notoginseng saponins is realized. The method disclosed by the invention is simple, feasible and high in production efficiency without organic reagent pollution and residues.

Description

technical field [0001] The invention relates to a preparation method of Panax notoginseng saponins, in particular to a preparation method of Panax notoginseng total saponins based on membrane coupling technology, and belongs to the field of medicine. Background technique [0002] The total saponins of Panax notoginseng are the main active ingredients in the traditional Chinese medicine Panax notoginseng. At present, it has been made into the main active part or raw material for the production of preparations, such as: Xuesaitong injection, powder injection for Tongluo Qingnao injection, etc. The market prospect good. Panax notoginseng saponins have the effects of promoting blood circulation and removing blood stasis, dredging channels and collaterals, and at the same time inhibiting platelet aggregation and increasing cerebral blood flow. It is used for cerebrovascular sequelae, central retinal vein occlusion, anterior chamber hemorrhage, etc. It also has the effect of hemo...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/258
Inventor 李存玉彭国平李红阳支兴蕾李贺敏
Owner NANJING UNIVERSITY OF TRADITIONAL CHINESE MEDICINE