Ultrasonic extraction method of artemisinin

An extraction method, ultrasonic technology, applied in the field of extraction and separation of active ingredients of traditional Chinese medicine, can solve the problems of cumbersome process, low cost, and shortened extraction time, and achieve the effects of simplifying the process, reducing costs, and shortening the extraction time

Inactive Publication Date: 2014-06-04
杨超
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The present invention aims to solve the problems of long extraction time, cumbersome process and high cost in the above-mentioned prior art, and provides an ultrasonic extraction method of artemisinin, so that the extraction time is greatly shortened under the premise of ensuring the extraction rate, and the cost is low

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] An ultrasonic extraction method for artemisinin, comprising the following process steps:

[0022] A. Pretreatment

[0023] Artemisia annua leaves are baked and dried in an oven, then pulverized into powder to make Artemisia annua leaf powder;

[0024] B. Petroleum ether extraction

[0025] Add petroleum ether to the Artemisia annua leaf powder obtained in step A, stir and extract;

[0026] C. Ultrasonic enhanced extraction

[0027] Put the Artemisia annua leaf powder extracted with petroleum ether in a water bath, insert the ultrasonic probe into the water bath, conduct ultrasonic extraction at 10KHz, 50W for 8 minutes, stir while extracting, and then repeat the extraction 3 times according to the above process parameters, each extraction The time is 2 minutes.

Embodiment 2

[0029] An ultrasonic extraction method for artemisinin, comprising the following process steps:

[0030] A. Pretreatment

[0031] Artemisia annua leaves are baked and dried in an oven, then pulverized into powder to make Artemisia annua leaf powder;

[0032] B. Petroleum ether extraction

[0033] Add petroleum ether to the Artemisia annua leaf powder obtained in step A, stir and extract;

[0034] C. Ultrasonic enhanced extraction

[0035] Put the Artemisia annua leaf powder extracted with petroleum ether in a water bath, insert an ultrasonic probe into the water bath, conduct ultrasonic extraction at 30KHz, 100W for 10 minutes, stir while extracting, and then repeat the extraction 6 times according to the above process parameters, each extraction The time is 5 minutes.

Embodiment 3

[0037] An ultrasonic extraction method for artemisinin, comprising the following process steps:

[0038] A. Pretreatment

[0039] Artemisia annua leaves are baked and dried in an oven, then pulverized into powder to make Artemisia annua leaf powder;

[0040] B. Petroleum ether extraction

[0041] Add petroleum ether to the Artemisia annua leaf powder obtained in step A, stir and extract;

[0042] C. Ultrasonic enhanced extraction

[0043] Put the Artemisia annua leaf powder extracted with petroleum ether in a water bath, insert the ultrasonic probe into the water bath, conduct ultrasonic extraction at 20KHz, 80W for 9 minutes, stir while extracting, and then repeat the extraction 4 times according to the above process parameters, each extraction The time is 4 minutes.

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PUM

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Abstract

The invention relates to an ultrasonic extraction method of artemisinin, and belongs to the technical fields of extraction and separation of effective components of traditional Chinese medicines. The method comprises the following steps: putting artemisia apiacea leaf powder extracted by petroleum ether into water bath after pretreatment and petroleum ether extraction, and inserting an ultrasonic probe into the water bath; carrying out ultrasonic extraction under the conditions of 10-30KHz and 50-100W for 8-10 minutes; and extracting while agitating, and then repeatedly extracting for 3-6 times according to the technological parameters, wherein each extraction time is 2-5 minutes. The artemisinin in the artemisia apiacea leaves is extracted by adopting the ultrasonic extraction method, the problems of long extraction time and low extraction rate of an ethanol reflux method, a decocting method and an ion exchange resin method in the prior art are solved, the problems that the product extracted by the existing ultrasonic extraction technology is high in purity, but the overall process is fussy, and high in cost, and consumes a lot of time are also solved, the extraction time is greatly shortened under the premise of ensuring the extraction rate, the technology is simplified, and the cost is reduced.

Description

technical field [0001] The invention relates to a method for extracting active ingredients of traditional Chinese medicine, more specifically, the invention relates to an ultrasonic extraction method of artemisinin, which belongs to the technical field of extraction and separation of active ingredients of traditional Chinese medicine. Background technique [0002] Artemisinin is a sesquiterpene lactone drug with peroxy groups extracted from the traditional Chinese medicine Artemisia annua. Its effect on the ultrastructure of the red inner stage of Plasmodium murine is mainly the change of the membrane system structure of Plasmodium. The drug first acts on the food vesicle, pellicle, mitochondria, and endoplasmic reticulum. In addition, it also has a certain effect on the chromatin in the nucleus. Impact. It is suggested that the mode of action of artemisinin is mainly to interfere with the function of pellicle-mitochondrion. It may be that artemisinin acts on the food vesi...

Claims

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Application Information

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IPC IPC(8): C07D493/20
CPCC07D493/20
Inventor 杨超
Owner 杨超
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