A magnetic anisotropic janus microsphere with controllable particle size and shape, its preparation method and the microfluidic control device used therein

Abstract

The invention discloses a magnetic isomerism Janus microsphere with controllable grain size and morphology as well as a preparation method thereof and a used microfluid control device. The preparation method of the magnetic isomerism Janus microsphere with controllable grain size and morphology is characterized by comprising the following steps: firstly, preparing magnetic micro grains; then respectively preparing a disperse phase I solution, a continuous phase solution and a disperse phase II solution on which magnetic micro grains are uniformly distributed; controlling the flow speeds of the disperse phase I solution, the disperse phase II solution and the continuous phase solution as well as the viscosity of the continuous phase solution; acquiring magnetic isomerism Janus liquid drops with different grain sizes and morphologies and homogeneous diameter sizes after the disperse phase I solution, the disperse phase II solution and the continuous phase solution are merged; curing the magnetic isomerism Janus liquid drops, thereby obtaining the magnetic isomerism Janus microsphere with controllable grain size and morphology. The method provided by the invention is used for preparing the magnetic isomerism Janus microsphere with the grain size range of 200-800 micron successfully, and the grain size and the morphology of the magnetic isomerism Janus microsphere are controlled by regulating and controlling; the method is simple and is easy to operate.

Description

technical field [0001] The invention relates to the field of preparation of Janus microspheres, in particular to a magnetically heterogeneous Janus microsphere with controllable particle size and shape, a preparation method and a device thereof. Background technique [0002] At the 1991 Nobel Prize Awarding Conference, deGennes first used "Janus" (the double-faced god of ancient Rome) to describe particles with different properties on the two hemispheres of the surface. If one side of a Janus microsphere has magnetic properties and the other side does not, it is called a magnetically heterogeneous Janus microsphere. [0003] Magnetically heterogeneous Janus microspheres can be widely used in biomedical applications, such as drug delivery, magnetic resonance imaging detection, nucleic acid separation, and environmental treatment, such as sewage, due to their rapid response to external magnetic fields to achieve corresponding control. Pollution control and recycling, etc. To...

AI Technical Summary

Problems solved by technology

Techniques such as topology-selective surface modification, template-directed self-assembly, controllable phase separation, and controllable surface nucleation methods have been used to prepare Janus particles, but the limited yield and difficult control of particle size and shape limit their wide application. The fatal shortcoming, and it is not very adaptable to the preparation of magnetically heterogeneous Janus microspheres

YinNing et al. produced magnetically heterogeneous Janus microspheres using a chemical method based on Pickering-type doubleemulsions. Although this method is simple, it is difficult to control the particle size and shape of the microspheres. Other preparation methods also face the same problem.

Images