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Gastrodin in-situ gel for treating inner ear diseases

A technology of gastrodin and gel, which is applied in the field of pharmaceutical preparations containing organic active ingredients, can solve the problems of negligible dosage and difficulty in reaching the labyrinth area of ​​the inner ear, and achieve the goals of promoting efficiency, improving bioavailability, and prolonging residence time Effect

Inactive Publication Date: 2014-06-25
SOUTHERN MEDICAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, gastrodin is mainly administered orally or intravenously. The drug is distributed throughout the body, and it is difficult to reach the labyrinth area of ​​the inner ear. The amount of drug in the lesion is very small, which directly affects its curative effect.

Method used

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  • Gastrodin in-situ gel for treating inner ear diseases
  • Gastrodin in-situ gel for treating inner ear diseases
  • Gastrodin in-situ gel for treating inner ear diseases

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] 1. Prescription: Gastrodin 10g, deacetylated gellan gum 0.5g, mint oil 1g, ethylparaben 0.03g, purified water 100g.

[0037] 2. Preparation method: Weigh deacetylated gellan gum and ethyl paraben, add 80g of purified water, dissolve at 90°C and let cool to room temperature, add gastrodin, refrigerate the dissolved solution at 4°C for 24 hours, and then pass through Filtrate through a fused glass funnel, add peppermint oil and the remaining purified water, stir evenly, and divide into packages to obtain the product.

Embodiment 2

[0039] 1. Prescription: gastrodin 20g, sodium alginate 0.8g, borneol 2g, benzalkonium chloride 0.02g, purified water 100g.

[0040] 2. Preparation method: Weigh sodium alginate and benzogadolinium ammonium chloride, add 80g of purified water, dissolve at 90°C and let cool to room temperature, then add gastrodin, the dissolved solution is refrigerated at 4°C for 24 hours and then vertically melted Filter through a glass funnel, add borneol fine powder, then add the remaining purified water to a sufficient amount, stir evenly, and divide into packages to obtain.

Embodiment 3

[0042] 1. Prescription: Gastrodin 10g, deacetylated gellan gum 0.3g, peppermint oil 0.5g, ethylparaben 0.05g, purified water 100g.

[0043] 2. Preparation method: Weigh deacetylated gellan gum and ethyl paraben, add 80g of purified water, dissolve at 90°C and let cool to room temperature, then add gastrodin, refrigerate the dissolved solution at 4°C for 24 hours, and then Filter through a vertically fused glass funnel, add peppermint oil, and then add the remaining purified water to a sufficient amount, stir evenly, and pack separately to obtain.

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PUM

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Abstract

The invention relates to gastrodin in-situ gel for treating inner ear diseases, wherein the inner ear diseases include meniere disease, sudden deafness and vestibular neuronitis. The gastrodin in-situ gel is characterized by being composed of the components in parts by weight: 10-20 parts of gastrodin, 0.3-0.8 part of ion-activated gel material, 0.5-2 parts of transfer accelerant, 0.02-0.05 part of preservative and 100 parts of purified water. The in-situ gel provided by the invention is suitable for intranasal administration and capable of remarkably increasing the efficiency for transferring gastrodin from the auditory tube to the inner ear and greatly increasing the local bioavailability of gastrodin to the inner ear.

Description

technical field [0001] The invention relates to medical preparations, in particular to a medical preparation containing organic active ingredients. Background technique [0002] Inner ear diseases such as Meniere's disease, idiopathic sudden deafness, and vestibular neuronitis can cause symptoms such as vertigo, tinnitus, and hearing loss, which bring great suffering to patients. According to estimates by the World Health Organization, there are about 250 million hearing disabled people in the world, and the prevalence rate of the elderly is higher than 30%. The blood labyrinth barrier (BLB) of the inner ear is an important system necessary to ensure the special functions of the inner ear. Any factors that damage the blood labyrinth barrier, such as free radicals, stress hormones, noise exposure, aminoglycoside antibiotics, etc., may cause cochlear damage. Changes in the internal environment affect the function of the inner ear. With the increasing impact of environmental ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/06A61K31/7034A61P27/16
Inventor 蔡铮刘中秋雷晓璐伍飞臻张琪林炎辉梁淑仪梁淑婷
Owner SOUTHERN MEDICAL UNIVERSITY
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