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Method for preparing antibacterial borate glass bracket

A technology of antibacterial glass and borate, applied in the field of biomedical materials, can solve the problems of bacterial drug resistance and low drug efficacy, and achieve the effects of low cost, easy operation and high compressive strength

Inactive Publication Date: 2014-07-02
TONGJI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, this method has the following shortcomings: bacterial resistance, drug burst release, lower drug efficacy in different physiological environments, etc.

Method used

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  • Method for preparing antibacterial borate glass bracket
  • Method for preparing antibacterial borate glass bracket
  • Method for preparing antibacterial borate glass bracket

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0040] Preparation of silver-doped 0.05% salt antibacterial glass stent

[0041] like figure 1 as shown, figure 1 It is the preparation method flowchart of borate antibacterial glass support shown in embodiment 1.

[0042] (1) Preparation of glass powder

[0043] According to the composition of the borate bioglass in Table 1, the oxides, chlorides, carbonates, sulfates and phosphates corresponding to the metal oxides are weighed as glass batch materials, and the purity of the raw materials is analytically pure. After mixing evenly, Put the original ingredients in a platinum crucible at 1150°C and melt for 1 hour. Then quenching to obtain a glass block; the obtained glass block is coarsely crushed by a horizontal ball mill, finely crushed by a jet mill, and sieved to obtain a glass powder with a final particle size of 0.05-50 μm.

[0044] Table 1

[0045]

[0046] (2) Preparation of glass slurry

[0047] Mix the glass powder obtained in step (1) with ethyl cellulose an...

Embodiment 2

[0052] Preparation of silver-doped 1% antibacterial and degradable borate bioactive glass scaffolds

[0053] (1) Preparation of glass powder

[0054] According to the composition of the borate bioglass in Table 2, the oxides, chlorides, carbonates, sulfates and phosphates corresponding to the metal oxides are weighed as glass batch materials, the purity of the raw materials is analytically pure, after mixing evenly, Put the original ingredients in a platinum crucible and melt at 1300°C for 1.5h. Then quenching to obtain a glass block; the obtained glass block is coarsely crushed by a horizontal ball mill, finely crushed by a jet mill, and sieved to obtain a glass powder with a final particle size of 0.05-50 μm.

[0055] Table 2

[0056]

[0057] (2) Preparation of glass slurry

[0058] Mix the glass powder obtained in step (1) with ethyl cellulose and absolute ethanol at a mass ratio of 3:0.12:2.5. Use a ball mill to mix absolute ethanol and ethyl cellulose for 30 minut...

Embodiment 3

[0063] Preparation of silver-doped 0.5% borate antibacterial glass stent

[0064] (1) Preparation of glass powder

[0065] According to the composition of the borate bioglass in Table 3, the oxides, chlorides, carbonates, sulfates and phosphates corresponding to the metal oxides are weighed as glass batch materials. The purity of the raw materials is analytically pure. After mixing evenly, Put the original ingredients in a platinum crucible at 1200°C and melt for 1.5h. Then quenching to obtain a glass block; the obtained glass block is coarsely crushed by a horizontal ball mill, finely crushed by a jet mill, and sieved to obtain a glass powder with a final particle size of 0.05-50 μm.

[0066] table 3

[0067]

[0068] (2) Preparation of glass slurry

[0069] Mix the glass powder obtained in step (1) with ethyl cellulose and absolute ethanol at a mass ratio of 3:0.12:2.5. Use a ball mill to mix absolute ethanol and ethyl cellulose for 30 minutes, then put in glass powde...

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Abstract

The invention discloses a method for preparing an antibacterial borate glass bracket. The method comprises the following steps: uniformly mixing glass components composed of an outer network body with molar percentage of 44% and a network forming body with molar percentage of 56%; fusing at a temperature of 1000-1400 DEG C, and performing heat preservation for 0.5-1.5 hours to obtain glass liquid; quenching the glass liquid to obtain a glass block; carrying out coarse crushing, fine crushing and sieving on the obtained glass block in sequence to obtain glass powder; mixing the obtained glass powder with ethyl cellulose and absolute ethyl alcohol according to a mass ratio of 3:0.12:2.5; firstly flat-grinding and mixing absolute ethyl alcohol with ethyl cellulose, and putting the mixture in the glass powder to obtain glass slurry; mixing the prepared glass slurry with a polyurethane template, then extruding the excessive slurry to prepare a grouting glass bracket, drying, sintering and cooling to obtain the antibacterial borate glass bracket. The antibacterial borate glass bracket prepared by the method disclosed by the invention has an excellent antibacterial effect, has no biological resistance, and has long-term sustained release antibacterial property, and high-temperature stable and acid-base stable antibacterial property.

Description

technical field [0001] The invention belongs to the technical field of biomedical materials, in particular to a method for preparing a borate antibacterial glass bracket. Background technique [0002] In the 1980s, American scholars such as Langer proposed a new concept of regenerative medicine called tissue engineering, which attracted great attention from the medical and material science circles. Tissue engineering is to use the principles and methods of biological science and engineering science to research and develop a new generation of clinically applied substitutes that can repair or improve the functions of human tissues and organs, and are used to replace part or all of the functions of tissues or organs. Among them, inorganic tissue engineering materials are favored because of their good mechanical properties, high biocompatibility, and easy formation of strong chemical bonds with the surrounding bone tissue. [0003] Bacterial infection caused by the implantation...

Claims

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Application Information

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IPC IPC(8): C03C14/00C03C12/00C03B19/06
Inventor 王德平王会黄文旵崔旭沈悠曲蒋飞
Owner TONGJI UNIV
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