Application of curcumin in preparation of drug used for resisting colitis

Abstract

The invention especially relates to application of curcumin in preparation of a drug used for resisting colitis and further provides application of curcumin in preparation of a drug used for resisting ulcerative colitis, belonging to the field of medicine. According to the invention, through adjusting activity of a plurality of transcription factors and blocking a plurality of signal paths, curcumin inhibits expression of a plurality of inflammation factors and chemotactic factors, reduces neutrophil infiltration and improves tissue damage and symptoms of colitis. Curcumin has a treatment effective rate of more than 90% in treatment of inflammatory bowl diseases, especially ulcerative colitis, obviously reinforces treatment effects on inflammatory bowl diseases and has small side-effects.

Description

technical field [0001] The invention belongs to the field of medicine, in particular to an application of curcumin in the preparation of anti-enteritis medicine. Background technique [0002] Inflammatory bowel disease (IBD) mainly includes ulcerative colitis (UC) and Crohn's disease (Crohn's disease) ， CD) is a group of intestinal inflammatory diseases characterized by chronic recurrent non-specific tissue inflammation, mainly manifested as long-term recurrent abdominal pain, diarrhea, mucus, pus and blood in the stool. So far, its pathogenesis has not yet been fully clarified. It is generally believed that multiple factors such as intestinal infection, intestinal mucosal barrier damage, intestinal mucosal immune regulation, genetics and environment are involved in the occurrence and development of IBD. play an important role in the pathogenesis. [0003] At present, the drug treatment of inflammatory bowel disease (IBD) is mainly based on 5-aminosalicylic acid preparatio...

AI Technical Summary

Problems solved by technology

In the acute attack period, hydrocortisone or dexamethasone can also be infused intravenously, and hydrocortisone can be added to normal saline every night as a retention enema. The value of hormone therapy in the acute attack period is certain, but in There are still differences in whether hormones should be used continuously in the chronic phase. Since it has certain side effects, most of them do not advocate long-term use

Also, the value of immunosuppressants in ulcerative colitis is questionable

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