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Folium eucalypti extractive with uric acid reduction effect as well as preparation method and application thereof

An extract and technology for lowering uric acid, applied in the field of eucalyptus leaf extract, medicine for treating hyperuricemia, and preparation field, achieving the effect of low price, abundant resources, and simple preparation method

Inactive Publication Date: 2014-07-16
曹庸
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there is no report on the use of eucalyptus leaf extract to treat hyperuricemia and gout

Method used

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  • Folium eucalypti extractive with uric acid reduction effect as well as preparation method and application thereof
  • Folium eucalypti extractive with uric acid reduction effect as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] Freshly collected 30Kg of eucalyptus leaves, dried in the dark, pulverized to 60 mesh, added with mixed extraction solvent (concentration of 70% ethanol 240kg, citric acid 4.8Kg), extracted at 40°C for 1.5 hours, filtered by plate and frame, and added mixed extraction solvent again (180Kg of ethanol with a concentration of 70%), then extracted at 40 ° C for 1.5 hours, centrifuged again, the filtrate was combined, entered into a still, concentrated under reduced pressure to 10L, and recovered ethanol, spray-dried, and removed the solvent to obtain a thick eucalyptus leaf. The extract, with a total polyphenol content of 26.54%, can be used to prepare a drug for treating hyperuricemia.

Embodiment 2

[0023] Freshly collected 40Kg of eucalyptus leaves, dried in the dark, pulverized to 60 mesh, added with mixed extraction solvent (320kg of ethanol with a concentration of 70%, 6.4Kg of citric acid), extracted at 42 °C for 1 hour, filtered by plate and frame, and then added to mixed extraction The solvent (240Kg of ethanol with a concentration of 70%) was extracted again at 38°C for 2 hours, centrifugally filtered, the filtrate was combined, entered into the still, concentrated to 12L, and the ethanol was recovered, extracted with 60L of ethyl acetate, shunted, and 48L was added. The ethyl acetate was extracted for the second time, separated, and 48L of ethyl acetate was added again for the third extraction. The extracts were combined, concentrated and recovered with ethyl acetate, spray-dried, and the solvent was removed to obtain the eucalyptus ethyl acetate extract. The phenol content is 33.89%, which can be used to prepare medicines for treating hyperuricemia.

Embodiment 3

[0025] Freshly collected 50Kg of eucalyptus leaves, dried in the dark, crushed to 60 mesh, added with mixed extraction solvent (400kg of ethanol with a concentration of 70%, 8Kg of citric acid), extracted at 39°C for 1.5 hours, filtered by plate and frame, and added with mixed extraction solvent again (300Kg of ethanol with a concentration of 70%), extracted again at 41°C for 1.5 hours, centrifuged again, combined the filtrates, entered the still, concentrated to 17L, and recovered ethanol, extracted with 85L of n-butanol, shunted, and then added 68L The second extraction of n-butanol, the third extraction of 68L n-butanol was added again, the extracts were combined, concentrated and recovered n-butanol, and the treated Diaion HP-20 macroporous resin column on the concentrated solution was extracted. The high ratio was 1:6, the ratio of sample loading to resin mass was 1:8, the flow rate was 6BV / h, and eluted with water and 10%, 20%, and 30% ethanol in turn, rinsed with 2 colum...

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Abstract

The invention discloses an application of a folium eucalypti extractive serving as an active ingredient in preparation of medicines for treating hyperuricemia, and also provides a preparation method of the folium eucalypti extractive. Main active ingredients of the folium eucalypti extractive are 6-12% of scabish essence B, 1-2% of tellimagrandin I, 1-1.5% of quercetin-3-O-glucoside acid, 0.8-1.2% of ellagic acid, 0.2-0.5% of tellimagrandin II, 0.1-0.15% of 1,2,3,4,6 pentagalloylglucose and 25-50% of total phenols. The pharmacological experiment shows that the folium eucalypti extractive has an inhibiting effect on xanthine oxidase and relatively strong effects of reducing uric acid, protecting renal injury caused by the hyperuricemia and the like in bodies.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicines, and in particular relates to an extract of eucalyptus leaves, a preparation method and its application in medicine for treating hyperuricemia. Background technique [0002] Hyperuricemia, a clinical symptom caused by gout, is a group of diseases caused by purine metabolic disorders. Tophaceous chronic arthritis and joint deformity often involve the kidneys, causing chronic interstitial nephritis and uric acid nephrolithiasis, and may lead to metabolic syndrome and related cardiovascular diseases. It has been listed as 21 by the United Nations One of the chronic diseases of the 20th century. [0003] Drugs for the prevention and treatment of hyperuricemia are mainly divided into uric acid production inhibitors (such as allopurinol, febuxostat, etc.) and uricosuric drugs (such as probenecid, benzbromarone, etc.). Xanthine oxidase is the most important enzyme in the process...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/61A61P19/06A61P13/12
Inventor 谭荣威曹庸刘又豪肖苏尧赵力超陈洪璋陈运娇
Owner 曹庸
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