Anastrozole sustained-release capsule

A technology of anastrozole and sustained-release capsules, applied in the field of anastrozole sustained-release capsules, can solve the problems of ineffective control of the release amount, poor safety, and poor effectiveness.

Inactive Publication Date: 2014-07-30
赵辉
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The object of the present invention is to provide a kind of anastrozole sustained-release capsule, it can overcome the current anastrozole common dosage form drug release amount and can not effectively control, cause the shortcoming of poor safety and effectiveness, and can reduce the total dosage of medicine And the curative effect is good

Method used

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Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0017] The preparation process of the above-mentioned Anastrozole Sustained-release Capsules, it adopts following several processes to prepare:

[0018] (1) Extrusion spheronization method: use an extrusion spheronizer to mix the raw material medicine and excipients through an 80-mesh screen, spray the mixed powder with a binder in the extrusion spheronizer, and then extrude and spheronize Make pellets, dry and sieve to obtain drug-containing pellets with a certain mesh size. Coating with ethyl cellulose aqueous dispersion in a fluidized bed coating pan;

[0019] (2) Powder coating method: use a non-porous coating pan, a water chestnut-shaped coating pan, a fluidized bed top spray (or bottom spray) coating machine, and a fluidized bed tangential spray to make pellets. Take the water chestnut-shaped coating pot as an example: mix the medicinal powder and excipients through an 80-mesh sieve, take a certain number of pellets (sucrose pills or microcrystalline cellulose pills) in...

Embodiment 1

[0023] An anastrozole sustained-release capsule is composed of 0.1% anastrozole, 94.9% excipient, 3% film coating material, 1% wetting agent and 1% binder. Wherein the excipient is microcrystalline cellulose, the film coating material is ethyl cellulose aqueous dispersion, the wetting agent is 75% ethanol solution, and the binder is aqueous solution of hydroxypropyl methyl cellulose.

[0024] A preparation process of anastrozole sustained-release capsules, which is prepared by the following processes:

[0025] Utilize extruding spheronization method: utilize extruding spheronizing granulator, crude drug and microcrystalline cellulose are mixed and crossed 80 mesh screens, mix powder with the aqueous solution of hydroxypropyl methylcellulose in extruding spheronizing granulator After spraying wet, extrude and spheronize to form pellets, and after drying, sieve to obtain drug-containing pellets with a certain mesh size, which are coated with ethyl cellulose aqueous dispersion in...

Embodiment 2

[0027] An anastrozole sustained-release capsule, wherein the sustained-release capsule is composed of 5% anastrozole, 78% excipient, 10% film coating material, 5% wetting agent and 2% binder. Wherein the excipient is starch, the film coating material is ethyl cellulose aqueous dispersion, the wetting agent is aqueous solution, and the binding agent is alcohol solution of polyvinylpyrrolidone.

[0028] A preparation process of anastrozole sustained-release capsules, which is prepared by the following processes:

[0029] Powder coating method: use a non-porous coating pan, a water chestnut-shaped coating pan, a fluidized bed top spray (or bottom spray) coating machine, and a fluidized bed tangential spray pellet machine to make pellets. Take the water chestnut-shaped coating pot as an example: mix the medicine powder and starch through an 80-mesh sieve, take 30-35 mesh pellets (sucrose pills or microcrystalline cellulose pills) into the water chestnut-shaped coating pot, and use...

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Abstract

The invention provides an anastrozole sustained-release capsule. The capsule is prepared from the following components in percentage by weight: 0.1-5 percent of anastrozole, 60-95 percent of excipient, 3-10 percent of a film coating material, 0-10 percent of a wetting agent and 1-2 percent of an adhesive. The preparation method adopts the following methods to prepare the anastrozole sustained-release capsule: (1) extrusion-spheronization method; (2) powder coating method; (3) liquid-phase deposition method.

Description

field of invention [0001] The invention relates to a sustained-release capsule, in particular to an anastrozole sustained-release capsule. Background of the invention [0002] Anastrozole is a highly efficient and highly selective non-steroidal aromatase inhibitor. The main source of estradiol in postmenopausal women is the conversion of androstenedione to estrone by the aromatase complex in peripheral tissues, which is then converted to estradiol. Reducing circulating estradiol levels proved beneficial for women with breast cancer. Highly sensitive analytical tests have shown that postmenopausal women taking 1 mg of anastrozole daily can reduce estradiol levels by more than 80%. Anastrozole has no progesterone-like, androgen-like and estrogen-like activities, and is suitable for the treatment of advanced breast cancer in postmenopausal women. For patients with negative estrogen receptors, if it has a positive clinical response to tamoxifen , can be considered for adjuvan...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/52A61K31/4196A61P35/00
Inventor 赵辉赵冠淇郭涛胡晓川
Owner 赵辉
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