Bilastine sustained-release capsule

A technology of sustained-release capsules and bilastine, which is applied in the directions of drug delivery, respiratory diseases, organic active ingredients, etc., can solve the problems of ineffective control of the release amount, poor safety and effectiveness

Inactive Publication Date: 2014-04-23
于运红
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] The purpose of the present invention is to provide a bilastine sustained-release capsule, which can overcome the disadvantages that the drug release amount of the current bilastine common dosage form cannot be effectively controlled, resulting in poor safety and effectiveness, and can reduce medication total dose and good efficacy

Method used

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  • Bilastine sustained-release capsule

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preparation example Construction

[0018] The preparation process of the above-mentioned bilastine sustained-release capsules adopts the following several processes to prepare:

[0019] (1) Extrusion spheronization method: use an extrusion spheronizer to mix the raw material medicine and excipients through an 80-mesh screen, spray the mixed powder with a binder in the extrusion spheronizer, and then extrude and spheronize Make pellets, dry and sieve to obtain drug-containing pellets with a certain mesh size. Coating with ethyl cellulose aqueous dispersion in a fluidized bed coating pan;

[0020] (2) Powder coating method: use a non-porous coating pan, a water chestnut-shaped coating pan, a fluidized bed top spray (or bottom spray) coating machine, and a fluidized bed tangential spray to make pellets. Take the water chestnut-shaped coating pot as an example: mix the medicinal powder and excipients through an 80-mesh sieve, take a certain number of pellets (sucrose pills or microcrystalline cellulose pills) into...

Embodiment 1

[0024] A bilastine sustained-release capsule is composed of 5% bilastine, 90% excipient, 3% film coating material, 1% wetting agent and 1% binder. Wherein the excipient is microcrystalline cellulose, the film coating material is ethyl cellulose aqueous dispersion, the wetting agent is 75% ethanol solution, and the binder is aqueous solution of hydroxypropyl methyl cellulose. A kind of preparation technology of bilastine sustained-release capsule, it adopts following technology to prepare:

[0025] Utilize extruding spheronization method: utilize extruding spheronizing granulator, crude drug and microcrystalline cellulose are mixed and crossed 80 mesh screens, mix powder with the aqueous solution of hydroxypropyl methylcellulose in extruding spheronizing granulator After spraying wet, extrude and spheronize to form pellets, and after drying, sieve to obtain drug-containing pellets with a certain mesh size, which are coated with ethyl cellulose aqueous dispersion in a fluidized ...

Embodiment 2

[0027] A bilastine sustained-release capsule, wherein the sustained-release capsule is made up of 8% bilastine, 75% excipient, 10% film coating material, 5% wetting agent and 2% binding agent . Wherein the excipient is starch, the film coating material is ethyl cellulose aqueous dispersion, the wetting agent is aqueous solution, and the binding agent is alcohol solution of polyvinylpyrrolidone.

[0028] A kind of preparation technology of bilastine sustained-release capsule, it adopts following technology to prepare:

[0029] Powder coating method: use a non-porous coating pan, a water chestnut-shaped coating pan, a fluidized bed top spray (or bottom spray) coating machine, and a fluidized bed tangential spray pellet machine to make pellets. Take the water chestnut-shaped coating pot as an example: mix the medicine powder and starch through an 80-mesh sieve, take 30-35 mesh pellets (sucrose pills or microcrystalline cellulose pills) into the water chestnut-shaped coating pot,...

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Abstract

The invention discloses a bilastine sustained-release capsule which comprises the following components in percentage by weight: 5-8 percent of bilastine, 60-95 percent of excipient, 3-10 percent of film coating material, 0-10 percent of wetting agent and 1-2 percent of adhesive. A preparation method adopts (1) an extracting and rolling method; (2) a powder coating method; (3) a liquid phase deposition method to prepare the bilastine sustained-release capsule.

Description

field of invention [0001] The invention relates to a sustained-release capsule, in particular to a bilastine sustained-release capsule. Background of the invention [0002] Bilastine is a highly selective histamine H1 receptor antagonist without sedative effect, which is used for the treatment of allergic rhinoconjunctivitis and urticaria. This product has good safety and no commonly used antihistamine drugs exist The sedative effect and cardiotoxicity, its chemical structure formula is: [0003] [0004] Bilastine is a second-generation antihistamine H1 receptor antagonist developed by Spanish FAES company, which is used for oral treatment of allergic rhinoconjunctivitis and urticaria once a day. Dosage specification: Bilastine 20mg / tablet. Bilastine is a new type of long-acting histamine antagonist, which can selectively antagonize the surrounding H1 receptors and has no obvious affinity for muscarinic receptors. In the 1980s, the non-sedating second-generation H1 re...

Claims

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Application Information

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IPC IPC(8): A61K9/52A61K31/454A61P37/08A61P11/02A61P17/00
Inventor 于运红陈天丽王雅冬毛玉琳
Owner 于运红
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