A kind of long-acting antibacterial drug oil emulsion and preparation method thereof

Abstract

A long-acting antimicrobial medical oil emulsion belongs to a long-acting antimicrobial medical dosage form and comprises aqueous phase with antimicrobial medicine, oil phase, emulsifier and stabilizer, wherein the oil phase adopts 7# or 15# of white oil, the aqueous phase emulsifier is Tween-80, the oil phase emulsifier is Span-80; and the aqueous phase is covered by oil to be dispersed in the oil phase. The dosage form can fully control the release of the antimicrobial action of active ingredients of the antimicrobial medicine, save the breeding cost, reduce the environmental pollution, and the like; and the dosage form is suitable for the preparation of active ingredients of various water-soluble or oil-soluble antimicrobial medicines. The invention provides the corresponding technical support for healthy raise in aspects of chemoprophylaxis and treatment of diseases.

Description

technical field [0001] The present invention relates to a modification of the dosage form of an antibacterial drug, more specifically, a modification of a long-acting slow-release dosage form of a veterinary antibacterial drug, especially a veterinary antibacterial drug, and a preparation method of the dosage form. Background technique [0002] In recent years, veterinary long-acting preparations (Long-acting Preparations) have attracted much attention, and its development and application have become a new hot spot. Due to the advantages of long-acting preparations in reducing the number of administrations and dosages, effectively saving costs, reducing animal stress, human expenditure, and environmental pollution, long-acting preparations for veterinary use have become ideal products expected by the majority of breeding users. Long-acting preparation is a new type of preparation in modern pharmaceutical preparations. Its advantages are that it can release and deliver drugs ...

AI Technical Summary

Problems solved by technology

Existing suspoemulsions have many deficiencies in the application fashion in production practice: firstly, the scope of application is limited, and it is difficult to fully popularize and apply, because water-soluble drugs are difficult to disperse in the oil phase, and the current suspoemulsion long-acting preparations are all It is an antibacterial drug that is insoluble in water or unstable in aqueous solution, but the problem is that most antibacterial active ingredient drugs are easily soluble in water, and this part of antibacterial active ingredient drugs is more difficult to make long-acting preparations of suspoemulsion type

In addition, the current suspoemulsions have relatively large toxic and side effects in clinical application. When applying long-acting preparations, the dosage of drugs is often large at one time. It is difficult to be transported to the liver and other organs in a short time and be metabolized rapidly, so the toxic and side effects of the drug are doubled

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