55 results about "Chemoprophylaxis" patented technology

A composition is provided for chemoprevention of an oral cancer or precancerous condition, including an isolated berry preparation admixed with a bioadhesive carrier. The carrier may be a mucoadhesive gel. The berry preparation may be derived from one or more of strawberry, raspberry, red raspberry, and black raspberry. Methods for producing the compositions are provided also. There are also provided methods for chemoprevention of an oral cancer or precancerous condition, utilizing the compositions of the invention. Still further, methods for enhancing stability of an anthocyanin contained in the berry preparation of the invention are provided, along with methods for enhancing efficacy of the compositions.

Aromatase inhibitors (AIs) are disclosed which are useful in the treatment and prevention of post-menopausal breast cancer. New AIs derived from natural products are disclosed that are evaluated for clinical utility for treating post-menopausal breast cancer and may also act as chemopreventive agents for preventing breast cancer. Several pure compounds demonstrated AI activity using a noncellular, enzyme-based microsomal and a cell-based aromatase assay. Correlations are made between structural classes with levels of aromatase inhibition. The disclosure may be utilized to direct synthetic modification of natural product scaffolds to enhance aromatase inhibition or to standardize botanical dietary supplements for increased aromatase inhibition activity.

A long-acting antimicrobial medical oil emulsion belongs to a long-acting antimicrobial medical dosage form and comprises aqueous phase with antimicrobial medicine, oil phase, emulsifier and stabilizer, wherein the oil phase adopts 7# or 15# of white oil, the aqueous phase emulsifier is Tween-80, the oil phase emulsifier is Span-80; and the aqueous phase is covered by oil to be dispersed in the oil phase. The dosage form can fully control the release of the antimicrobial action of active ingredients of the antimicrobial medicine, save the breeding cost, reduce the environmental pollution, and the like; and the dosage form is suitable for the preparation of active ingredients of various water-soluble or oil-soluble antimicrobial medicines. The invention provides the corresponding technical support for healthy raise in aspects of chemoprophylaxis and treatment of diseases.

The invention relates to a method for extracting and purifying sesquiterpene coumarin aether in the field of chemical technology, which comprises the steps as follows: step 1: southernwood roots are smashed and ultrasonically extracted with methanol; the extracting solution is rotary-evaporated and condensed to obtain extract which is then delaminated by adopting acetic ether and water double-phase dispersion and extraction; the acetic ether organic phase of an upper layer is taken as an extracting concentrate; step 2: column chromatography is carried out after the extracting concentrate is added with an adsorbent; elution is carried out by using petroleum ether and acetic ether mixed eluant, and then thin-layer chromatography is carried out to collect components containing the sesquiterpene coumarin aether; step 3: the concentrate is furthered condensed to the extract which is then dispersed with methanol of same volume and then filtered with a nylon membrane, purified with the reversed-phase column of a preparative liquid phase ODS RP-C18 and eluted with mixture solution of methanol and water; and finally, the corresponding components are condensed. The invention has simple preparation method and easily available raw materials for preparation and can be applied to chemoprophylaxis and cure of tumors and development of relevant antitumor drugs.

The present invention refers to compounds of formula (I):

as well as to a method for their preparation, pharmaceutical compositions comprising the same, and use thereof for the treatment and/or chemoprevention of cancer, aging related diseases or processes, diabetes and neurodegenerative diseases.

The disclosure provides, among other things, a method of decreasing resistance to the chemopreventive properties of non-steroidal anti-inflammatory agents, e.g., celecoxib, particularly in the prevention of cancer, e.g., colon cancer, by increasing the levels or activity of 15-hydroxyprostaglandin dehydrogenase (15-PGDH). The disclosure also provides a method of identifying compounds that upregulate or reactivate 15-PGDH. The disclosure also provides a method of identifying an individual suitable for treatment with a non-steroidal anti-inflammatory agent in the treatment or prevention of colon cancer.

A method for preventing or treating colorectal cancer in a patient possessing human tropomyocin isoform TC22 is presented. Also presented is a method for evaluating TC22 expression reduction activity of a compound.

The invention provides compositions and methods for radio protection and chemo prevention using therapeutic and prophylactics methods of using (S,S)-SDG (R,R)- SDG, (S,R)-SDG (R,S)-SDG, SDG, SECO, EL, ED, analogs thereof, stereoisomers thereof and other related molecules. In one aspect, the invention relates to a method for protecting a biomolecule(such as genetic material like a nucleic acid, a protein or a lipid), a cell, or a tissue, from radiation damage in a subject in need thereof, the method comprising administering to said subject an effective amount of flaxseed, its bioactive ingredient, degradant or a metabolite thereof.

A method for automated detection, monitoring and treatment of dysplasia by analyzing 3D reconstructed images of cells obtained from a specimen includes a biological specimen classifier that classifiescells from the sputum specimen as normal or abnormal. If abnormal cells are detected, then the abnormal cells are further classified as pre-cancerous or cancerous. Pre-cancerous cells are further sub-classified as being of glandular origin or squamous origin (dysplastic cells). This information would be used to define patient therapy so that if the cells are classified as dysplastic, then a cancer chemoprevention pharmaceutical like iloprost is administered to the subject over a predetermined time period to achieve a therapeutic dosage, and if only malignant cells were found or malignant andpre-cancerous cells were found, then next steps would involve patient triage to biopsy and surgery and possibly use of a cancer chemoprevention pharmaceutical.

The invention belongs to the technical field of cancer treatment and prevention, and particularly relates to application of quercetin-3-methylether in chemoprophylaxis of esophagus cancer. The quercetin-3-methylether is used for chemoprophylaxis of a canceration process of esophagus cancer. The overall design idea of the invention is as follows: during an esophageal canceration process of a rat induced with NMBA, through influencing the incidence rate and diversity of precancerous lesion and judging the expression situation of KI67,c-Jun indexes by use of an immunohistochemical method, the chemoprophylaxis effect of the quercetin-3-methylether on esophagus cancer is judged. According to the application, through constructing an esophageal canceration model process of the white rat induced with NMBA, the effect of quercetin-3-methylether on esophagus cancer is specifically evaluated. Results indicate that when quercetin-3-methylether with proper concentration has a favorable effect of preventing the canceration process of esophagus cancer and providing a new concept and reference possibility for chemoprophylaxis of esophagus cancer.