Long-acting antimicrobial medical oil emulsion and preparation method thereof

A technology of antibacterial drugs and oil emulsions, which is applied in the preparation of the dosage form and the change of long-acting sustained-release dosage forms, can solve problems such as difficult to make long-acting suspension emulsion preparations, difficult to fully popularize and apply, unstable antibacterial drugs, etc. Achieve the effects of reducing the total dosage of medication, great market potential, and reducing the number of administrations

Active Publication Date: 2010-07-07
湖南慧谷农业生态研究院有限公司
View PDF0 Cites 4 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Existing suspoemulsions have many deficiencies in the application fashion in production practice: firstly, the scope of application is limited, and it is difficult to fully popularize and apply, because water-soluble drugs are difficult to disperse in the oil phase, and the current suspoemulsion long-acting preparations are all It is an antibacterial drug that is insoluble in water or unstable in aqueous solution, but the problem is that most antibacterial active ingredient drugs are easily solu

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Long-acting antimicrobial medical oil emulsion and preparation method thereof
  • Long-acting antimicrobial medical oil emulsion and preparation method thereof
  • Long-acting antimicrobial medical oil emulsion and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] Preparation and Application of Superlong-acting Ciprofloxacin Compound Oil Emulsion

[0032] Ciprofloxacin (CPLX), also known as ciprofloxacin, is the one with the strongest antibacterial activity against Gram-negative bacteria among the fluoroquinolones currently used in veterinary clinical practice. DNA gyrase to exert its rapid bactericidal effect. Ciprofloxacin has the advantages of high fat solubility, long after-effect time after antibacterial, wide distribution in the body and few adverse reactions, so it is widely used in veterinary clinics at home and abroad to treat infectious diseases. However, this excellent drug is currently only available in oral preparations and common injections in veterinary clinics, and multiple administrations are required to achieve a better control effect. Therefore, developing a long-acting new dosage form of ciprofloxacin and giving full play to its good clinical effect in veterinary medicine has broad application prospects for p...

Embodiment 2

[0160] Preparation and application of super long-acting enrofloxacin compound oil emulsion

[0161] Enrofloxacin is also known as ethyl ciprofloxacin and enrofloxacin. Systematic name: 1-cyclopropyl-7-(4-ethyl-1-piperazinyl)-6-fluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid. This product is currently designated as an animal-specific drug by the state. Pharmacokinetics: The absorption of oral administration and intramuscular injection is rapid and relatively complete, and the blood drug degree reaches the peak within 0.5-2 hours. In addition to the central nervous system, drug concentrations in almost all tissues are higher than plasma, which is beneficial to the treatment of systemic infection and deep tissue infection. This product is eliminated through renal and non-renal means, and about 15%-50% of the original drug is excreted through urine. The metabolism in animals is mainly to remove the ethyl group and become ciprofloxacin. Pharmacological action: This product ...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

PropertyMeasurementUnit
Maximum tolerated doseaaaaaaaaaa
Maximum tolerated doseaaaaaaaaaa
Login to view more

Abstract

A long-acting antimicrobial medical oil emulsion belongs to a long-acting antimicrobial medical dosage form and comprises aqueous phase with antimicrobial medicine, oil phase, emulsifier and stabilizer, wherein the oil phase adopts 7# or 15# of white oil, the aqueous phase emulsifier is Tween-80, the oil phase emulsifier is Span-80; and the aqueous phase is covered by oil to be dispersed in the oil phase. The dosage form can fully control the release of the antimicrobial action of active ingredients of the antimicrobial medicine, save the breeding cost, reduce the environmental pollution, and the like; and the dosage form is suitable for the preparation of active ingredients of various water-soluble or oil-soluble antimicrobial medicines. The invention provides the corresponding technical support for healthy raise in aspects of chemoprophylaxis and treatment of diseases.

Description

technical field [0001] The present invention relates to a modification of the dosage form of an antibacterial drug, more specifically, a modification of a long-acting slow-release dosage form of a veterinary antibacterial drug, especially a veterinary antibacterial drug, and a preparation method of the dosage form. Background technique [0002] In recent years, veterinary long-acting preparations (Long-acting Preparations) have attracted much attention, and its development and application have become a new hot spot. Due to the advantages of long-acting preparations in reducing the number of administrations and dosages, effectively saving costs, reducing animal stress, human expenditure, and environmental pollution, long-acting preparations for veterinary use have become ideal products expected by the majority of breeding users. Long-acting preparation is a new type of preparation in modern pharmaceutical preparations. Its advantages are that it can release and deliver drugs ...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
IPC IPC(8): A61K9/107A61K45/00A61K47/34A61K47/46A61K47/38A61P31/04A61K47/26
Inventor 董伟李孝文孙志良
Owner 湖南慧谷农业生态研究院有限公司
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap