Adhesive patch
A technology of patch and adhesive layer, which is applied in the direction of anti-inflammatory agents, non-central analgesics, medical preparations of non-active ingredients, etc., and can solve pain, insufficient skin adhesion, and decreased permeability of diclofenac, etc. pain reduction, excellent skin permeability, and excellent adhesion
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Embodiment 1
[0104] First, weigh 5.0 parts by mass of glycerin, 35.0 parts by mass of D-sorbitol aqueous solution (70 mass%), 10.0 parts by mass of butanediol (1,3-butanediol), 5.0 parts by mass of polyethylene glycol Glycol monooleate (the average addition mole number of oxyethylene groups: 6), 1.0 parts by mass of diclofenac sodium, 0.5 parts by mass of menthol, 7.0 parts by mass of water-soluble polymer 1 (mass of sodium polyacrylate: carboxyl group Sodium methylcellulose mass=5:2), 0.5 parts by mass of adhesion enhancer, 6.0 parts by mass of inorganic filler, 0.44 parts by mass of cross-linking agent, 0.25 parts by mass of pH regulator, 0.02 parts by mass of sodium sulfite , 0.02 parts by mass of dibutylhydroxytoluene, and 29.27 parts by mass of purified water were mixed to obtain an adhesive layer (paste layer) composition. Next, the obtained adhesive layer composition was adjusted to 1000 g / m 2 The method is in the non-woven fabric containing polyester fiber (head payment: 100g / m 2...
Embodiment 2～6
[0121] An adhesive patch (paste) was obtained in the same manner as in Example 1 except that the composition of the adhesive layer composition was set to the composition shown in Table 4, respectively. Table 4 shows the results of the skin penetration test (12 hours), the rolling ball adhesion test, and the time-dependent coloring evaluation test of the obtained patch, together with the composition of the adhesive layer composition. In addition, the water-soluble polymer 2 described in Table 4 contained sodium polyacrylate, sodium carboxymethylcellulose, gelatin, and hydroxypropylcellulose in this order at a mass ratio of 5:1.25:2:3.
[0122] [Table 4]
[0123]
[0124] From the results shown in Table 4, it can be clearly confirmed that in the patch containing a large amount of sodium sulfite (Example 2), and the patch containing sodium sulfite and sodium pyrosulfite or sodium bisulfite (Examples 3-4), especially It can suppress the discoloration of the adhesive layer.
Embodiment 7～19、 comparative example 18～19
[0126] An adhesive patch (paste) was obtained in the same manner as in Example 1 except that the composition of the adhesive layer composition was set to the compositions shown in Tables 5 to 6, respectively. The results of the skin penetration test (12 hours), the rolling ball tack test, and the shape retention evaluation test of the patches obtained in Examples 7 to 9 and Comparative Examples 18 to 19 were compared with the composition of the adhesive layer composition. They are shown in Table 5 together. In addition, the results of Example 2 are also shown in Table 5 together. Furthermore, the results of the rolling ball adhesion test on the patches obtained in Examples 10 to 19 are shown in Table 6 together with the composition of the adhesive layer composition.
[0127] [table 5]
[0128]
[0129] [Table 6]
[0130]
[0131] From the results shown in Table 5, it was clearly confirmed that in the patch (Comparative Example 18) in which the ratio of the mass of but...
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Abstract
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