A kind of preparation method of biodegradable polylactic acid-polyethylene glycol block copolymer

A technology of block copolymer and polyethylene glycol, which is applied in the field of preparation of biodegradable copolymers, can solve the problems of difficult control of side reactions and wide molecular weight distribution, and achieve less side reactions, good controllability, and low reaction temperature Effect

Active Publication Date: 2016-05-11
苏州岸谷纳米技术有限公司
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Problems solved by technology

Although the above-mentioned patents have reported the use of multiple methods for preparing polylactic acid-polyethylene glycol block copolymers, there are still deficiencies in various degrees such as wide molecular weight distribution and difficult control of side reactions in each method. The present invention intends to adopt a new A new method for the preparation of polylactic acid-polyethylene glycol block copolymers using a catalytic system

Method used

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  • A kind of preparation method of biodegradable polylactic acid-polyethylene glycol block copolymer
  • A kind of preparation method of biodegradable polylactic acid-polyethylene glycol block copolymer
  • A kind of preparation method of biodegradable polylactic acid-polyethylene glycol block copolymer

Examples

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Embodiment 1

[0032] With 100 ml of tetrahydrofuran as a solvent, dissolve 0.1 g of polyethylene glycol with a molecular weight of 2000, add metal potassium and naphthalene at a molar ratio of polyethylene glycol terminal hydroxyl: potassium: naphthalene = 1:1:1, and add 0.4 g under nitrogen protection. After reacting at 25°C for 48 hours, add 10 ml of acetic acid, concentrate and precipitate in a large amount of ether to obtain a polylactic acid-polyethylene glycol triblock copolymer.

Embodiment 2

[0033] Example 2: With 50 milliliters of dioxane as a solvent, dissolve 5 grams of polyethylene glycol monomethyl ether with a molecular weight of 5000, and add it according to the molar ratio of polyethylene glycol terminal hydroxyl: sodium: naphthalene = 1:10:1 Metal sodium and naphthalene, under the protection of nitrogen, add 10 grams of lactide in 50 ml of dioxane solution, react at 60 ° C for 24 hours, add 5 ml of hydrochloric acid, concentrate and precipitate in a large amount of ether to obtain polylactic acid-poly Ethylene glycol diblock copolymer.

Embodiment 3

[0034] Example 3: Using 50 ml of methylpyrrolidone as a solvent, dissolve 50 grams of polyethylene glycol monomethyl ether with a molecular weight of 1000, and add the metal according to the molar ratio of polyethylene glycol terminal hydroxyl: sodium: naphthalene = 1:5:1 Sodium and naphthalene, add 50 grams of lactide in 50 milliliters of methyl pyrrolidone solution under nitrogen protection, react at 50 ° C for 18 hours, add 5 milliliters of formic acid, concentrate and precipitate in a large amount of ether to obtain polylactic acid-polyethylene glycol Alcohol Diblock Copolymer.

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Abstract

The invention discloses a preparation method for a biodegradable polylactic acid-polyethylene glycol block copolymer. The preparation method comprises the following steps: dissolving polyethylene glycol (PEG) or methoxy polyethylene glycol (mPEG) in anorganic solvent, in the presence of active metal and organic compound naphthalene, adding lactide, reacting for a period of time under a protective atmosphere, adding acid to end the reaction, and purifying so as to obtain the polylactic acid-polyethylene glycol block copolymer. The method uses an anionic polymerization mechanism for preparing the polylactic acid-polyethylene glycol block copolymer, the molecular weight has better controllability, the distribution of the molecular weight is narrow, the reaction temperature is low, and side effects are few.

Description

technical field [0001] The invention relates to a preparation method of a biodegradable copolymer, belonging to the field of biomedical polymer materials. Background technique [0002] Cancer is a common multiple major disease that seriously endangers human health. According to the 2014 World Cancer Report (World Cancer Report 2014) released by the World Health Organization, the incidence of cancer in China ranks first in the world. Researching efficient treatments for cancer is a task of great practical significance. Chemotherapy has been widely used in the clinical treatment of cancer. However, the side effects of chemotherapy drugs are one of the main causes of death of patients. important question. The development of nano drug delivery system provides the possibility to solve this problem. Nanoparticles loaded with anti-tumor drugs utilize the high permeability and retention (EPR) effect of tumor tissue blood vessels to gather into tumor tissue, which can reduce the d...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08G63/08C08G63/83
Inventor 何斌陈建华
Owner 苏州岸谷纳米技术有限公司
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