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Preparing method and application of externally-used gel-type lotion containing sophora alopecuroides of alkaloid

A technology for total alkaloids and Sophora japonicas, which is applied in the fields of medicine, health care products and food, can solve the problems that the total alkaloids of Sophora japonica cannot fully exert the bacteriostatic effect, the contact time between the drug and the lesion site is short, the preparation is complicated, etc. Protects health and overcomes the effects of short and long residence times

Inactive Publication Date: 2014-08-27
陈卫斌
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the traditional solution type lotion of total alkaloids of Sophora sophora has a short contact time between the drug and the lesion, the preparation is complicated, and it is easy to leak, so it cannot give full play to the good antibacterial effect of total alkaloids of sophora

Method used

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  • Preparing method and application of externally-used gel-type lotion containing sophora alopecuroides of alkaloid

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] (1) Take 125 g of the total alkaloid of Sophora flavescens, 25 g of surfactant, 1.1 g of lauryl alcohol and 3 g of pH adjuster and dissolve them with a certain amount of water to prepare a liquid medicine.

[0020] (2) Take 85 g of carboxymethyl cellulose and pour it on the water surface, let it stand for swelling, and prepare a gel after the swelling is complete.

[0021] (3) After mixing the gel and the medicinal solution, the volume is set to 1000ml, and the mixture is evenly stirred. Placed for natural defoaming, inspected, autoclaved, and packed, and it is ready.

Embodiment 2

[0023] (1) Take 140 g of total alkaloids of Sophora serrata, 35 g of surfactant, 76 g of glycerin and 10 g of vitamin C and dissolve them with a certain amount of water to prepare a liquid medicine.

[0024] (2) Take 60g of sodium carboxymethyl cellulose and pour it on the surface of the medicinal solution, leave it to swell, add 2.3g of menthol after the swelling is complete, and take another 11g of pH regulator to adjust the pH to the specified range, and finally dilute to 1000ml. Stir evenly, place for natural defoaming, test, autoclave, and pack, ready to go.

Embodiment 3

[0026] (1) Take 50 g of the total alkaloids of Sophora flavescens, 50 g of propylene glycol, 4.8 g of borneol, 48 g of surfactants, 2 g of flavors and 1 g of pigments and dissolve them with quantitative water to prepare a medicinal solution.

[0027] (2) Take 85 g of carbomer and 40 g of carboxymethyl cellulose and pour it on a quantitative water surface and let it stand for swelling. After the swelling is complete, add 20 g of a pH regulator to a specified pH value to prepare a gel.

[0028] (3) After mixing the gel and the medicinal solution, the volume is set to 1000ml, stirred evenly, placed for more than 12 hours, degassed under normal pressure, and packed after inspection.

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Abstract

The invention relates to an externally-used gel-type lotion containing sophora alopecuroides of alkaloid. The externally-used gel-type lotion comprises the sophora alopecuroides of alkaloid, a gel substrate, a permeability accelerant, a surface active agent, a humectant, a pH modifier, fragrance, coloring matter and the balance purified water, wherein every 1000 ml externally-used gel-type lotion comprises 1 to 5 percent of the sophora alopecuroides of alkaloid, 1 to 15 percent of the gel substrate, 0 to 0.5 percent of the permeability accelerant, 0.5 to 5 percent of the surface active agent, 0 to 10 percent of the humectant, 0.1 to 2 percent of the pH modifier, 0 to 1 percent of the fragrance and 0 to 1 percent of the coloring matter. The good antibacterial effect of the extract of pure natural plant sophora alopecuroides and the advantages of gels are used, and the gel-type lotion obvious in antibacterial effect and long in residence time of medicine on the site of action is prepared. Natural ingredients serve as the permeability accelerant, the dual effects of permeability acceleration and sterilization are achieved, and the externally-used gel-type lotion has the advantages of the broad spectrum, the strong bactericidal ability and the good nursing effect.

Description

Technical field [0001] The invention relates to the field of medical technology and health products and foods, in particular to a preparation method and application of a gel-type lotion for external use containing the total alkaloids of Sophora serrata. technical background [0002] Sophora sphaerocarpa comes from the legume Sophora genus, and its medicinal parts include sphaerocarpa seed, aerial parts and whole grass. The active ingredients are mainly alkaloids, which have significant antibacterial, anti-inflammatory, anti-tumor and other pharmacological effects. In the study, it was found that the antibacterial effect of the total alkaloids of Sophora sphaerocarpa on a variety of bacteria was significantly better than that of the total alkaloids of Sophora sphaerocarpa, such as the minimum inhibitory concentration (MIC) and minimum bactericidal concentration of the total alkaloids of Sophora sphaerocarpa (MBC) were 1.56mg / ml and 3.13mg / ml, but the MIC and MBC of the total alkal...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/489A61K9/06A61P31/02A61P15/00A61P17/00
Inventor 王文苹陈卫斌隋宏许珊珊
Owner 陈卫斌
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