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Blood processing hollow fiber membrane, blood purifier and manufacturing method thereof

A blood treatment and fibrous membrane technology, applied in chemical instruments and methods, membrane technology, suction devices, etc., can solve the problems of reduced permeability, large changes in performance reduction ratios, and reduced performance, and achieves the effect of less performance changes.

Active Publication Date: 2014-08-27
ASAHI KASEI MEDICAL CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0024] However, in the manufacturing method of the hollow fiber membrane based on the above-mentioned coating method, there is a problem that a large decrease in performance (such as a decrease in permeability) occurs during the process of immobilizing the fat-soluble vitamin to the matrix hollow fiber membrane, and its performance Large fluctuations in reduction ratio

Method used

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  • Blood processing hollow fiber membrane, blood purifier and manufacturing method thereof
  • Blood processing hollow fiber membrane, blood purifier and manufacturing method thereof
  • Blood processing hollow fiber membrane, blood purifier and manufacturing method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0284] 17.5% by mass of polyethersulfone (PES) (4800P manufactured by Sumitomo Chemical Co., Ltd.), 3.5% by mass of polyvinylpyrrolidone (PVP) (K90 manufactured by BASF JAPAN LTD.) as a hydrophilic agent, and 1.0% of water as a non-solvent % by mass, triethylene glycol (TEG) (manufactured by Mitsubishi Chemical Co., Ltd.) 31.2 mass%, dimethylacetamide (DMAc) as a solvent (manufactured by Mitsui Chemicals Co., Ltd.) 46.8 mass % of the spinning dope was maintained at 45 The outer slit of the double-layer spinneret of ℃ is ejected, and the water as the internal liquid is ejected from the inner ejection hole of the double-layer spinneret, and it passes through the air gap with an air gap length of 600mm and a spinning speed of 60m / min. , immersed in a 70°C coagulation bath (DMAc:TEG:water=6:4:90).

[0285] Thereafter, it was washed in pure water at 45° C. for 1 minute and in pure water at 80° C. for 90 seconds, and wound up on a straw to obtain a hollow fiber membrane with an inne...

Embodiment 2

[0293] In the spinning dope, PVP (K90 manufactured by BASF JAPAN LTD.) was 3.0% by mass, the solvent dimethylacetamide (DMAc) (manufactured by Mitsui Chemicals Co., Ltd.) was 47.3% by mass, and the vitamin E concentration of the covering solution was 0.45% by mass , except that, a blood purifier was obtained in the same manner as in Example 1.

[0294] The content of vitamin E on the surface of the hollow fiber membrane in the obtained blood purifier is 150mg / m 2 , the ratio of vitamin E present on the inner surface to the vitamin E present in the entire hollow fiber membrane is 70% by mass, and the ratio of polyvinylpyrrolidone (PVP) present on the inner surface of the hollow fiber membrane to PES and polyvinylpyrrolidone ( The ratio of the sum of PVP) was 25% by mass, and the amount of IPA contained in 1 g of the hollow fiber membrane was 950 μg.

Embodiment 3

[0296] In the spinning stock solution, polyvinylpyrrolidone (PVP) (K90 manufactured by BASF JAPAN LTD.) was 3.3% by mass, and the solvent dimethylacetamide (DMAc) (manufactured by Mitsui Chemicals, Ltd.) was 47.0% by mass.

[0297] As the coating solution, a 57% by mass aqueous solution of isopropyl alcohol in which 0.45% by mass of vitamin E was dissolved was used. After the coating solution was passed through the inner cavity of the hollow fiber membrane at a temperature of 20°C, the air was flashed immediately to remove the residual liquid in the inner cavity, and then ventilated with dry air at 24°C in an isopropanol atmosphere for 45 minutes to dry out the solvent. The other conditions were the same as in Example 1 to obtain a blood purifier.

[0298] The content of vitamin E on the surface of the hollow fiber membrane in the obtained blood purifier is 150mg / m 2 , the ratio of the vitamin E present on the inner surface to the vitamin E present in the entire hollow fiber...

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Abstract

The invention refers to a blood processing hollow fiber membrane, a blood purifier and a manufacturing method thereof. The subject aims to obtain a blood processing hollow fiber membrane which maintain oxidation resistance under harsh environment such as high temperature preservation and change less due to lipid-soluble vitamin. The blood processing hollow fiber membrane comprises A-D; the surface of the blood processing hollow fiber membrane contains, calculating by membrane area, lipid-soluble vitamin in a scope above 10 mg / m2 and below 300 mg / m2; the content of the lipid-soluble vitamin on the surface of the blood processing hollow fiber membrane is over 50 mass % of the whole content of the lipid-soluble vitamin of a blood processing hollow fiber membrane, wherein A is polyether sulfone resin, B is hydrophilic polymer, C is lipid-soluble vitamin and D is ketone and / or alcohol with less than four carbons.

Description

technical field [0001] The present invention relates to a hollow fiber membrane for blood treatment, and in particular, to a polyethersulfone hollow fiber membrane for blood treatment, a blood purifier including the hollow fiber membrane for blood treatment, and a method for manufacturing the blood purifier. Background technique [0002] Various hollow fiber membrane blood purifiers, such as hemodialyzers, hemofilters, and hemodialysis filters, have been widely used in blood purification therapy such as renal failure treatment to remove uremic toxins and waste products in the blood. , the blood purifier has a hollow fiber for blood treatment using polymers such as cellulose, cellulose diacetate, cellulose triacetate, polysulfone, polyethersulfone, polymethyl methacrylate, polyacrylonitrile, etc. membrane as the separation material. [0003] These hollow-fiber membrane-type blood purifiers are excellent in reducing the volume of blood in extracorporeal circulation, improving...

Claims

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Application Information

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IPC IPC(8): B01D69/08B01D71/68A61M1/18
Inventor 鸟田美和子川上淳也
Owner ASAHI KASEI MEDICAL CO LTD
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