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Composite artificial ligament and preparation method thereof

A technology of artificial ligament and weaving net, applied in ligament, medical science, muscle and other directions, can solve the problems of artificial ligament elongation, foreign body rejection, ligament surface cells and tissues cannot grow normally, etc., and achieve the effect of promoting growth.

Active Publication Date: 2014-09-17
SHENZHEN LANDO BIOMATERIALS
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, such materials are often accompanied by some defects: the material is not degradable and absorbable, and the wear debris of the artificial ligament can cause iatrogenic joint disease; the biocompatibility is not good, the cells and tissues on the surface of the ligament cannot grow normally, and it is easy to cause foreign body rejection; The artificial material has high hardness, no periodic relaxation, and is prone to fatigue and fracture; with the creep of the active ligament in the joint, the artificial ligament will be permanently elongated, resulting in instability of the knee joint
In addition, although some artificial ligaments have mesh, surrounding cells and tissues can grow into them, but before the artificial ligament breaks, the tissue that grows into the mesh of the artificial ligament will never be stimulated by normal stress and will not become a normal ligament at all. Tissue, once the artificial ligament is broken, it will be found that the tissue growing into the mesh is too soft and too elastic to maintain the function of the anterior cruciate ligament
These defects lead to the problem that the artificial ligament cannot be used for a long time
At present, artificial ligaments provided by the invention of artificial ligaments are mostly band-shaped or tubular. Although these two structures are simple in structure, their mechanical properties and degradation properties are often difficult to meet the requirements of ligaments.

Method used

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  • Composite artificial ligament and preparation method thereof
  • Composite artificial ligament and preparation method thereof
  • Composite artificial ligament and preparation method thereof

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Effect test

preparation example Construction

[0036] In the preparation method of the present invention, it is formed by spinning or spinning, compounding into threads, weaving into nets, rolling the nets into rods and reinforcing them with non-woven needle punching technology by spinning or spinning several components in sequence, so that even in the degradation process , The structure of the product still maintains a mesh shape, and the mesh gradually becomes larger, which is more suitable for the attachment of surrounding tissues and the repair and growth of ligament tissue.

[0037] The semi-degradable composite artificial ligament of the present invention is composed of three components with different degradation properties: component one, component two and component three through spinning or spinning, compounding into threads, weaving into nets, rolling the nets into rods and using them. It is reinforced by spinning needle punching technology. The preparation method of the composite artificial ligament of the present i...

Embodiment 1

[0048] Choose collagen and poly(ε-caprolactone) as two raw materials, use surgical suture preparation method to spun into filament or bundle respectively, choose polyethylene terephthalate to spun by melt spinning method Filament or bundle, the diameter of single filament is 1-50μm, and the number of filaments contained in a single bundle is 1-20.

[0049] The three-component tows are prepared according to the number ratio of 1:1:1 to prepare a thread with the component three tow as the inner core, and the component one and the second component tow are entangled on the inner core, and pass through the web forming machine Weave the threads into a net-like structure with a mesh diameter ranging from 150 to 300 μm. Finally, the net-like structure is rolled into a 6 mm rod-like structure. Non-woven needle punching technology is used to entangle the threads in the rod-like structure to form a net. Hole staggered structure.

[0050] The initial tensile strength of the artificial ligamen...

Embodiment 2

[0052] Two kinds of raw materials, polyglycolic acid and poly β-hydroxybutyrate are selected, and the surgical suture preparation method is used to spun into filaments or bundles, and the ultra-high molecular weight polyethylene is spun into filaments or by melt spinning. Bundle shape, in which the diameter of single filament is 1-50μm, and the number of filaments contained in a single bundle is 1-20.

[0053] The three component tows are prepared according to the number ratio of 1:1:2 to prepare a thread with the component three tow as the inner core, and the component one and the second component tow are entangled on the inner core, and pass through the web forming machine Weave the threads into a net-like structure with a mesh diameter ranging from 150 to 300 μm. Finally, the net-like structure is rolled into a rod-like structure with 10 mm. The non-woven needle punching technology is used to entangle the threads in the rod-like structure to form a mesh. Staggered structure.

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Abstract

The invention relates to a composite artificial ligament and a preparation method thereof. The composite artificial ligament has a rodlike structure formed by reeling of a woven net. The woven net has a net structure formed by weaving of threads. The threads in the rodlike structure tangle with each other to loop together so as to form a mesh interleaving structure. The threads are formed by winding of a variety of filament bundles with different degradation properties, and the variety of filament bundles with different degradation properties are respectively formed by spinning or beam spinning of components with different degradation properties, so that the obtained composite artificial ligament has gradient degradation performance. The composite artificial ligament provided by the invention has good mechanical properties, and can promote the attachment of surrounding tissue and the repair and normal growth of ligament tissue. At the same time, part of components in the body can be gradually biodegradable, and significant decline of the ligament's mechanical properties cannot be caused during degradation.

Description

technical field [0001] The invention relates to the technical field of implantable medical devices, in particular to a composite artificial ligament and a preparation method thereof. Background technique [0002] Due to the special biological environment in the knee joint and the limitation of the blood supply of the cruciate ligament, the body of the cruciate ligament has no natural healing ability after rupture, so ligament reconstruction is required. Restorative materials include autografts, allografts, and artificial ligaments. Autologous transplantation has problems such as insufficient donor site and donor site complications, and allogeneic transplantation has the risk of delayed ligamentization, immune rejection, and even the risk of disease transmission. In contrast, artificial ligaments have the advantages of simple operation, reliable and controllable material sources, no damage to autologous tissue, and good postoperative stability, and are more widely used in li...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/58A61L27/24A61L27/22A61L27/20A61L27/18A61L27/16A61F2/08
Inventor 谭荣伟许孟强魏欣苗
Owner SHENZHEN LANDO BIOMATERIALS
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